INT43489

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Context Info
Confidence 0.20
First Reported 1984
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 0.97
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Mtnr1a) plasma membrane (Mtnr1a) signal transducer activity (Mtnr1a)
Anatomy Link Frequency
impression 1
pituitary 1
brain 1
Mtnr1a (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 6 98.20 Very High Very High Very High
Antinociceptive 1 90.84 High High
alcohol 2 90.24 High High
Morphine 2 76.20 Quite High
Neuropeptide 2 76.00 Quite High
MU agonist 1 75.00 Quite High
antagonist 2 71.80 Quite High
Potency 1 65.92 Quite High
Opioid 1 50.28 Quite High
Action potential 14 50.00 Quite Low
Disease Link Frequency Relevance Heat
Dyskinesias 5 94.72 High High
Fatigue 1 91.36 High High
Stress 6 90.88 High High
Virilism 15 79.96 Quite High
Disease 1 50.64 Quite High
Aggression 7 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Shoulder Pain 4 5.00 Very Low Very Low Very Low
Lordosis 2 5.00 Very Low Very Low Very Low
Phobia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At higher doses, nor-BNI dose-dependently shifted the agonist dose-effect curves of CI-977, U50,488, U69,593 and bremazocine, but not those of EKC and Mr2034, suggesting that the latter compounds may be producing effects via nor-BNI-insensitive receptors.
Gene_expression (producing) of Mr2034 associated with agonist
1) Confidence 0.20 Published 1994 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7871070 Disease Relevance 0 Pain Relevance 0.58
A recent study of the expression of the pituitary melatonin receptor 1 (MT1) gene provides good evidence that the pituitary gland in hpg mice is arrested at an immature stage of development [22].
Gene_expression (expression) of melatonin receptor 1 in pituitary
2) Confidence 0.16 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1249589 Disease Relevance 0.08 Pain Relevance 0
ACTH1-39, and possibly also the anti-cellular 2100 Mr peptide, is initially synthesized as the precursor polyprotein pro-opiomelanocortin (POMC).
Gene_expression (synthesized) of anti-cellular 2100 Mr peptide
3) Confidence 0.10 Published 1984 Journal J. Immunol. Section Abstract Doc Link 6317743 Disease Relevance 0 Pain Relevance 0.07
This figure provides an impression of the stability of the relation between eMR and aMR in different conditions.
Gene_expression (impression) of aMR in impression
4) Confidence 0.05 Published 2006 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1557523 Disease Relevance 0 Pain Relevance 0
The aMR and corresponding eMR intercept values (?
Gene_expression (values) of aMR
5) Confidence 0.04 Published 2006 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1557523 Disease Relevance 0 Pain Relevance 0
The MR-1L isoform is specifically expressed in brain and is localized to the cell membrane while the MR-1S isoform is ubiquitously expressed and shows diffuse cytoplasmic and nuclear localization.
Gene_expression (expressed) of MR-1L isoform in brain
6) Confidence 0.00 Published 2004 Journal Hum. Mol. Genet. Section Abstract Doc Link 15496428 Disease Relevance 0.89 Pain Relevance 0.08

General Comments

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