INT43507

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Context Info
Confidence 0.78
First Reported 1984
Last Reported 2011
Negated 4
Speculated 1
Reported most in Body
Documents 79
Total Number 80
Disease Relevance 28.53
Pain Relevance 38.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gabbr1) plasma membrane (Gabbr1) transcription factor binding (Gabbr1)
cytoplasm (Gabbr1) signal transducer activity (Gabbr1)
Anatomy Link Frequency
neurons 18
spinal cord 7
dorsal root ganglia 5
nociceptors 4
anatomical sites 2
Gabbr1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 765 100.00 Very High Very High Very High
gABA 734 100.00 Very High Very High Very High
nociceptor 674 100.00 Very High Very High Very High
antagonist 185 100.00 Very High Very High Very High
Glutamate 183 100.00 Very High Very High Very High
analgesia 44 100.00 Very High Very High Very High
Opioid 41 100.00 Very High Very High Very High
Cannabinoid 2 100.00 Very High Very High Very High
Spinal cord 402 99.92 Very High Very High Very High
Morphine 178 99.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 20 100.00 Very High Very High Very High
Nociception 1599 99.40 Very High Very High Very High
Pain 1023 99.32 Very High Very High Very High
Inflammatory Pain 192 97.72 Very High Very High Very High
Targeted Disruption 408 97.32 Very High Very High Very High
Ganglion Cysts 37 97.24 Very High Very High Very High
Hyperalgesia 272 96.96 Very High Very High Very High
Frailty 32 96.08 Very High Very High Very High
Neuropathic Pain 618 94.96 High High
INFLAMMATION 298 94.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, GABAB receptors expressed in dorsal horn neurons have been shown to participate in the modulation of secondary hyperalgesia in monoarthritic rats, which is reduced by intrathecal injection of baclofen [16].
Gene_expression (expressed) of GABAB in neurons associated with hyperalgesia, dorsal horn neuron and intrathecal
1) Confidence 0.78 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785766 Disease Relevance 0.97 Pain Relevance 0.76
As noted previously GABAB receptor mRNA has been shown to be expressed in all DRG neurons [7].
Gene_expression (expressed) of GABAB receptor mRNA in neurons
2) Confidence 0.78 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785766 Disease Relevance 0.51 Pain Relevance 0.42
The expression of GABAB receptor subunits is enhanced in lumbal spinal cord and dorsal root ganglion following chronic nociceptive activation in models of axotomy and chemogenic pain [13].
Gene_expression (expression) of GABAB in spinal cord associated with nociception, ganglion cysts, pain, dorsal root ganglion and spinal cord
3) Confidence 0.78 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785766 Disease Relevance 0.89 Pain Relevance 0.99
However, analysis of nociceptor-specific GABAB(1) receptor mutants revealed that this anti-nociceptive activity of baclofen occurs independently of GABAB(1) expression in peripheral nociceptive neurons.
Gene_expression (expression) of GABAB in neurons associated with nociception and nociceptor
4) Confidence 0.78 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785766 Disease Relevance 1.01 Pain Relevance 0.66
Western blot analysis showed that in SNS-GABAB(1)-/- mice expression of GABAB(1) protein in the dorsal root ganglia (DRG) is largely reduced, whereas expression in the brain and spinal cord remains unchanged (Fig. 1A and 1B).
Gene_expression (expression) of GABAB in DRG associated with spinal cord
5) Confidence 0.78 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785766 Disease Relevance 0.15 Pain Relevance 0.32
A majority of GABAB(1) expressing DRG neurons are small-diameter neurons.
Gene_expression (expressing) of GABAB in neurons
6) Confidence 0.78 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785766 Disease Relevance 0.13 Pain Relevance 0.37
Thus, considerable support implicates a role for GABAB receptors expressed in peripheral nociceptive neurons in the endogenous modulation of nociception and pathological pain.
Gene_expression (expressed) of GABAB in neurons associated with nociception and pain
7) Confidence 0.78 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785766 Disease Relevance 0.87 Pain Relevance 0.75
However, GABAB receptors are also expressed postsynaptically on second order neurons and as well as at motor neuron synapses [11,12].
Gene_expression (expressed) of GABAB in neurons
8) Confidence 0.78 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785766 Disease Relevance 0.66 Pain Relevance 0.84
Amongst these, small-diameter nociceptive neurons show a high density of GABAB receptor expression [7,10].
Gene_expression (expression) of GABAB in neurons associated with nociception
9) Confidence 0.78 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785766 Disease Relevance 0.63 Pain Relevance 0.82
From these data, we infer that GABAB receptors expressed by A?
Gene_expression (expressed) of GABAB
10) Confidence 0.78 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785766 Disease Relevance 1.47 Pain Relevance 0.97
In transfected cells, functional GABAB receptors are usually only observed after coexpression of GABAB(1) and GABAB(2) subunits, which established the concept of heteromerization for G-protein-coupled receptors.
Gene_expression (coexpression) of GABAB
11) Confidence 0.77 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15240800 Disease Relevance 0 Pain Relevance 0.07
In transfected cells, functional GABAB receptors are usually only observed after coexpression of GABAB(1) and GABAB(2) subunits, which established the concept of heteromerization for G-protein-coupled receptors.
Gene_expression (coexpression) of GABAB
12) Confidence 0.77 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15240800 Disease Relevance 0 Pain Relevance 0.07
It therefore will be interesting to
address whether the production of the various secreted GABAB1
isoforms is regulated in response to physiological stimuli. 
Spec (whether) Gene_expression (production) of GABAB1
13) Confidence 0.77 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576543 Disease Relevance 0.07 Pain Relevance 0.15
In addition to the membrane-bound GABAB1a and GABAB1b
subunit isoforms, the GABAB1 gene produces several
secreted isoforms that all include the SDs
(14-16).

Gene_expression (produces) of GABAB1
14) Confidence 0.77 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576543 Disease Relevance 0.06 Pain Relevance 0
Western blot analysis showed that in SNS-GABAB(1)-/- mice expression of GABAB(1) protein in the dorsal root ganglia (DRG) is largely reduced, whereas expression in the brain and spinal cord remains unchanged (Fig. 1A and 1B).
Gene_expression (expression) of GABAB in DRG associated with spinal cord
15) Confidence 0.68 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785766 Disease Relevance 0.16 Pain Relevance 0.33
These include all of the known C-terminal variants of GABAB(1), such as GABAB(1a), which contributes largely to the GABAB(1) expression in nociceptors, GABAB(1b), and the additional, newly described GABAB(1e), that can mediate dominant-negative effects on GABAB receptor heteromerization and is indeed expressed in pain pathways [35].
Gene_expression (expression) of GABAB in nociceptors associated with pain and nociceptor
16) Confidence 0.68 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785766 Disease Relevance 0.26 Pain Relevance 0.48
In situ mRNA hybridisation using GABAB(1)-specific riboprobes revealed that only a small proportion of neurons expressing mRNA for GABAB(1) belongs to the group of large diameter neurons.
Gene_expression (expressing) of GABAB in neurons
17) Confidence 0.68 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785766 Disease Relevance 0.13 Pain Relevance 0.36
This might result from higher expression of GABAB(1) in A?
Gene_expression (expression) of GABAB
18) Confidence 0.68 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785766 Disease Relevance 0.58 Pain Relevance 0.48
In contrast, Engle et al. [46] found that spinal nerve ligation does not alter the expression or function of GABAB(1) and GABAB(2) in the spinal cord and dorsal root ganglia of rats and also does not lead to changes in GABAB receptor binding affinity in inflammatory and neuropathic states.
Gene_expression (expression) of GABAB in spinal cord associated with inflammation, spinal nerve ligature, neuropathic pain and spinal cord
19) Confidence 0.68 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785766 Disease Relevance 0.94 Pain Relevance 0.94
In contrast, Engle et al. [46] found that spinal nerve ligation does not alter the expression or function of GABAB(1) and GABAB(2) in the spinal cord and dorsal root ganglia of rats and also does not lead to changes in GABAB receptor binding affinity in inflammatory and neuropathic states.
Gene_expression (expression) of GABAB in spinal cord associated with inflammation, spinal nerve ligature, neuropathic pain and spinal cord
20) Confidence 0.68 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785766 Disease Relevance 0.94 Pain Relevance 0.95

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