INT43509

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Context Info
Confidence 0.13
First Reported 1983
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.26
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Avp, POMC) signal transduction (Avp, POMC) extracellular region (Avp, POMC)
small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC)
Anatomy Link Frequency
adrenal glands 4
Avp (Rattus norvegicus)
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 38 87.96 High High
Inflammation 134 85.24 High High
Morphine 9 84.96 Quite High
cytokine 62 80.08 Quite High
Inflammatory mediators 4 75.44 Quite High
Potency 2 75.00 Quite High
depression 2 69.36 Quite High
noradrenaline 2 53.32 Quite High
rheumatoid arthritis 162 32.92 Quite Low
Arthritis 36 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 8 86.16 High High
INFLAMMATION 142 85.24 High High
Adhesions 2 79.20 Quite High
Fever 2 70.68 Quite High
Depression 2 69.36 Quite High
Cancer 4 50.88 Quite High
Necrosis 4 50.40 Quite High
Disease 54 34.20 Quite Low
Rheumatoid Arthritis 162 32.92 Quite Low
Communicable Diseases 4 19.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Under the same conditions, CRF and AVP stimulated ACTH release to a greater degree at 10(-10) and 10(-9) M, respectively.
AVP Positive_regulation (stimulated) of Localization (release) of ACTH
1) Confidence 0.13 Published 1983 Journal Neuroendocrinology Section Abstract Doc Link 6318148 Disease Relevance 0 Pain Relevance 0.15
Arginine vasopressin (AVP) synergistically enhances CRH-stimulated ACTH release [10,11] ACTH in turn induces the expression and release of glucocorticoids from the adrenal glands.
Arginine vasopressin Positive_regulation (enhances) of Localization (release) of ACTH in adrenal glands
2) Confidence 0.06 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC333413 Disease Relevance 0.63 Pain Relevance 0.51
Arginine vasopressin (AVP) synergistically enhances CRH-stimulated ACTH release [10,11] ACTH in turn induces the expression and release of glucocorticoids from the adrenal glands.
AVP Positive_regulation (enhances) of Localization (release) of ACTH in adrenal glands
3) Confidence 0.06 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC333413 Disease Relevance 0.63 Pain Relevance 0.50

General Comments

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