INT43524

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Context Info
Confidence 0.58
First Reported 1983
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 19
Disease Relevance 2.95
Pain Relevance 5.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Sh2b2) cytoplasm (Sh2b2) signal transducer activity (Sh2b2)
Anatomy Link Frequency
neurons 9
Dorsal root 1
synapses 1
Sh2b2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Action potential 1267 100.00 Very High Very High Very High
sodium channel 10 99.76 Very High Very High Very High
potassium channel 5 98.20 Very High Very High Very High
dorsal root ganglion 72 97.64 Very High Very High Very High
tetrodotoxin 11 95.56 Very High Very High Very High
Neuronal excitability 22 94.48 High High
action potential duration 8 93.36 High High
Glutamate 33 87.76 High High
gABA 29 86.08 High High
substantia gelatinosa 43 84.24 Quite High
Disease Link Frequency Relevance Heat
Infection 760 99.60 Very High Very High Very High
Ganglion Cysts 184 97.64 Very High Very High Very High
Sprains And Strains 240 87.92 High High
Nervous System Injury 2 80.32 Quite High
Depression 45 66.40 Quite High
Pseudorabies 40 50.00 Quite Low
Dyspepsia 22 50.00 Quite Low
Non-diabetic Peripheral Neuropathy 1 50.00 Quite Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

8 32.08 Quite Low
Disseminated Intravascular Coagulation 1 25.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of note the membrane potential showed a sag in response to hyperpolarization while depolarization triggered action potentials (APs) in a tonic-like pattern.
Positive_regulation (triggered) of APs associated with action potential
1) Confidence 0.58 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18817844 Disease Relevance 0 Pain Relevance 0.41
Approximately 10% of neurons can also generate APs when sodium channels are blocked.
Positive_regulation (generate) of APs in neurons associated with action potential and sodium channel
2) Confidence 0.41 Published 1983 Journal Brain Res. Section Abstract Doc Link 6318906 Disease Relevance 0 Pain Relevance 0.53
When voltage sensitive potassium channels are blocked by TEA or when Ba is substituted for calcium, all the neurons are capable of generating large, overshooting, slow and prolonged, calcium-dependent APs.
Positive_regulation (generating) of APs in neurons associated with action potential and potassium channel
3) Confidence 0.41 Published 1983 Journal Brain Res. Section Abstract Doc Link 6318906 Disease Relevance 0 Pain Relevance 0.61
RESULTS: Compared with normal neurons, injury decreased the refractory interval (RI) for repeat action potential (AP) generation increased the number of APs during sustained depolarization, and shortened the after hyperpolarization following an AP.
Positive_regulation (increased) of APs in neurons
4) Confidence 0.27 Published 2004 Journal Acta Anaesthesiol Scand Section Body Doc Link 15025616 Disease Relevance 0.16 Pain Relevance 0
Given this number of vesicles in the RRP, if each has a Pv of 0.1 this indicates that sparse stimulation with single APs causes hippocampal synapses from rat neurons in primary culture to release, on average, 1 vesicle every 3 APs in standard conditions, (Pr?
Positive_regulation (single) of APs in synapses associated with action potential
5) Confidence 0.26 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2928663 Disease Relevance 0.18 Pain Relevance 0.27
F20: response to 20 APs at 100 Hz (average of at least 4 trials)
Positive_regulation (response) of APs
6) Confidence 0.26 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2928663 Disease Relevance 0 Pain Relevance 0.31
FBaf: response to 1200 APs at 10?
Positive_regulation (response) of APs
7) Confidence 0.26 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2928663 Disease Relevance 0 Pain Relevance 0.31
As a result, the number of APs per second would increase in any individually recorded neuron and also would lead to nearly synchronous activation of APs across neurons.
Positive_regulation (activation) of APs in neurons
8) Confidence 0.15 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2763221 Disease Relevance 0 Pain Relevance 0.14
This signal could then spread to other axons projecting from that cell, possibly inducing APs in the axons of other connected cells.
Spec (possibly) Positive_regulation (inducing) of APs
9) Confidence 0.15 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2763221 Disease Relevance 0 Pain Relevance 0.16
The number of APs generated during a long depolarizing current step fell from 5.3±0.5 to 3.5±0.3 (P<0.001, t-test).
Positive_regulation (generated) of APs
10) Confidence 0.13 Published 2010 Journal Neuroscience Section Body Doc Link PMC2877872 Disease Relevance 0 Pain Relevance 0.29
An important question is what induces APs in axons?
Positive_regulation (induces) of APs
11) Confidence 0.13 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2763221 Disease Relevance 0 Pain Relevance 0.37
However, perfusion of NaHS led to a significant increase in numbers of action potentials (APs) in 68.2% of the neurons (n = 15) evoked by two times rheobase current stimulation (Fig. 6B&6D).
Positive_regulation (increase) of APs in neurons associated with action potential
12) Confidence 0.12 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.38 Pain Relevance 0.48
We suggest small fusion pores formed between neurons, particularly those formed between axons, allow spontaneous APs generated in cell bodies to spread directly into coupled neurons.
Positive_regulation (generated) of APs in neurons
13) Confidence 0.09 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2763221 Disease Relevance 0 Pain Relevance 0.35
The shape of the induced APs for both infections was unusual and the induced spikelet-like events were clearly different from epsps characteristic of synaptic events.
Positive_regulation (induced) of APs associated with infection
14) Confidence 0.09 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2763221 Disease Relevance 0.54 Pain Relevance 0.19
As a result, the number of APs per second would increase in any individually recorded neuron and also would lead to nearly synchronous activation of APs across neurons.
Positive_regulation (increase) of APs in neurons
15) Confidence 0.09 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2763221 Disease Relevance 0 Pain Relevance 0.12
As PRV 151 infection progressed, neurons began to fire APs at elevated rates compared to mock-infected neurons (Figure 1C–E).
Positive_regulation (elevated) of APs in neurons associated with infection
16) Confidence 0.09 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2763221 Disease Relevance 0.56 Pain Relevance 0.21
PRV infected neurons fire APs at elevated rates by 8 hours post infection
Positive_regulation (elevated) of APs in neurons associated with infection
17) Confidence 0.09 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2763221 Disease Relevance 0.59 Pain Relevance 0.26
250 Hz stimulation at intensity below T5/T250 initiated APs in A?
Positive_regulation (initiated) of APs associated with action potential
18) Confidence 0.09 Published 2005 Journal Mol Pain Section Body Doc Link PMC1083421 Disease Relevance 0.08 Pain Relevance 0.25
Dorsal root stimulation with a suction electrode elicited antidromic APs with latencies in the range of 0.2 – 15.0 ms.
Positive_regulation (elicited) of APs in Dorsal root associated with action potential
19) Confidence 0.08 Published 2005 Journal Mol Pain Section Body Doc Link PMC1083421 Disease Relevance 0.45 Pain Relevance 0.52

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