INT43540

Context Info Confidence 0.01 First Reported 1984 Last Reported 1984 Negated 1 Speculated 0 Reported most in Abstract Documents 1 Total Number 3 Disease Relevance 0 Pain Relevance 1.03

transferase activity, transferring glycosyl groups (fut10) Golgi apparatus (fut10)

Anatomy Link Frequency brain 1 egg 1 fut10 (Rattus norvegicus)

Pain Link Frequency Relevance Heat sodium channel 9 98.84 tetrodotoxin 12 83.36

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These data indicate that the alpha, beta 1, and beta 2 subunits of the sodium channel are sufficient for reconstitution of both selective, veratridine-stimulated ion transport and 125I-LqTx binding.

LqTx Binding (binding) of associated with sodium channel

1) Confidence 0.01 Published 1984 Journal J. Biol. Chem. Section Abstract Doc Link 6319406 Disease Relevance 0 Pain Relevance 0.23

Purified sodium channels reconstituted in egg phosphatidylcholine vesicles do not bind 125I-scorpion toxin (125I-LqTx).

LqTx Neg (not) Binding (bind) of in egg associated with sodium channel

2) Confidence 0.01 Published 1984 Journal J. Biol. Chem. Section Abstract Doc Link 6319406 Disease Relevance 0 Pain Relevance 0.41

In contrast, when incorporated into vesicles containing rat brain lipids, 76% of the Na+ channels bound 125I-LqTx with an average KD of 80 nM.

LqTx Binding (bound) of in brain

3) Confidence 0.01 Published 1984 Journal J. Biol. Chem. Section Abstract Doc Link 6319406 Disease Relevance 0 Pain Relevance 0.39

General Comments

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