INT43552

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Context Info
Confidence 0.03
First Reported 1984
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.15
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RTCA) RNA binding (RTCA) nucleus (RTCA)
ligase activity (RTCA)
Anatomy Link Frequency
neocortex 2
RTCA (Homo sapiens)
Pain Link Frequency Relevance Heat
orphanin 9 100.00 Very High Very High Very High
opiate 3 100.00 Very High Very High Very High
agonist 3 99.92 Very High Very High Very High
Opioid 3 96.80 Very High Very High Very High
Potency 1 37.04 Quite Low
narcan 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Epilepsy 7 98.56 Very High Very High Very High
Glioma 2 90.52 High High
Neuroblastoma 2 90.16 High High
Sclerosis 3 88.96 High High
Cancer 1 86.32 High High
Convulsion 1 66.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of this work was to evaluate the level of G-proteins activation mediated by DAMGO (a mu receptor selective peptide) and nociceptin, and the binding to mu and nociceptin (NOP) receptors and adenylyl cyclase (AC) in neocortex of patients with pharmacoresistant temporal lobe epilepsy.
Negative_regulation (evaluate) of cyclase Binding (binding) of in neocortex associated with epilepsy and orphanin
1) Confidence 0.03 Published 2009 Journal Neurobiol. Dis. Section Abstract Doc Link 19573600 Disease Relevance 0.82 Pain Relevance 0.51
Pretreatment of membranes with 100 to 216 microM NEM resulted in a loss of the capacity of agonists to inhibit adenylate cyclase through muscarinic cholinergic and opiate receptors and a loss of GTP-sensitive high-affinity binding of agonists to both of these receptors.
Negative_regulation (inhibit) of cyclase Binding (binding) of associated with agonist and opiate
2) Confidence 0.03 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6319678 Disease Relevance 0.33 Pain Relevance 0.36

General Comments

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