INT43572

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Context Info
Confidence 0.04
First Reported 1983
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.35
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (PCDHB17) plasma membrane (PCDHB17)
Anatomy Link Frequency
brain 2
PCDHB17 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 4 100.00 Very High Very High Very High
addiction 2 99.42 Very High Very High Very High
agonist 3 99.32 Very High Very High Very High
opiate 7 99.20 Very High Very High Very High
Clonidine 1 98.52 Very High Very High Very High
mu opioid receptor 2 98.40 Very High Very High Very High
Thalamus 1 86.16 High High
opioid receptor 1 75.00 Quite High
medulla 1 71.84 Quite High
midbrain 1 58.32 Quite High
Disease Link Frequency Relevance Heat
Opiate Addiction 2 99.42 Very High Very High Very High
Overdose 1 95.04 Very High Very High Very High
Urological Neuroanatomy 2 87.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The biochemical status of human brain mu-opioid receptors and alpha 2-adrenoceptors during opiate dependence was studied by means of the binding of [3H] [D-Ala2, MePhe4, Gly-ol5] enkephalin (DAGO) and [3H]clonidine, respectively, in postmortem brains of heroin addicts who had died by opiate overdose or other causes.
MePhe4 Binding (binding) of in brain associated with addiction, mu opioid receptor, enkephalin, opiate, overdose and clonidine
1) Confidence 0.04 Published 1994 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7862885 Disease Relevance 0.35 Pain Relevance 0.65
The pharmacologically defined kappa agonist 3H-(-)-bremazocine and the mu-agonists 3H-dihydromorphine and 3H-D-Ala2,MePhe4, Gly-ol5-enkephalin bind to unique sites in microtome sections of human brain tissue.
MePhe4 Binding (bind) of in brain associated with agonist and enkephalin
2) Confidence 0.02 Published 1983 Journal Life Sci. Section Abstract Doc Link 6319868 Disease Relevance 0 Pain Relevance 0.69

General Comments

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