INT4358

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Context Info
Confidence 0.70
First Reported 1975
Last Reported 2010
Negated 9
Speculated 6
Reported most in Abstract
Documents 195
Total Number 201
Disease Relevance 30.79
Pain Relevance 77.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avp) extracellular space (Avp) extracellular region (Avp)
response to stress (Avp) signal transducer activity (Avp)
Anatomy Link Frequency
nucleus 24
neurohypophysis 24
pituitary 21
hypothalamus 19
neural lobe 18
Avp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 280 100.00 Very High Very High Very High
cva 102 100.00 Very High Very High Very High
Enkephalin 78 100.00 Very High Very High Very High
Nicotine 56 100.00 Very High Very High Very High
opiate 54 100.00 Very High Very High Very High
fluoxetine 38 100.00 Very High Very High Very High
Locus ceruleus 2 100.00 Very High Very High Very High
noradrenaline 56 99.98 Very High Very High Very High
carbamazepine 22 99.98 Very High Very High Very High
antagonist 265 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 9 100.00 Very High Very High Very High
Pressure And Volume Under Development 43 99.96 Very High Very High Very High
Body Weight 19 99.96 Very High Very High Very High
Pressure Volume 2 Under Development 38 99.84 Very High Very High Very High
Adenoma 13 99.80 Very High Very High Very High
Volume Depletion And Dehydration 18 99.68 Very High Very High Very High
Pain 37 99.44 Very High Very High Very High
Overactive Bladder 15 99.44 Very High Very High Very High
Opiate Addiction 4 99.42 Very High Very High Very High
Stress 182 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intraperitoneal injection of nicotine markedly increased AVP secretion in rats.
Positive_regulation (increased) of Localization (secretion) of AVP associated with nicotine
1) Confidence 0.70 Published 1988 Journal Clin Exp Hypertens A Section Abstract Doc Link 3243002 Disease Relevance 0 Pain Relevance 0.67
Intravenous injection of naloxone significantly increased the basal AVP level and carbachol-induced AVP secretion.
Positive_regulation (increased) of Localization (secretion) of AVP associated with narcan
2) Confidence 0.70 Published 1988 Journal Clin Exp Hypertens A Section Abstract Doc Link 3243002 Disease Relevance 0 Pain Relevance 0.66
Alpha 2-adrenergic stimulation within the nucleus tractus solitarius attenuates vasopressin release induced by depletion of cardiovascular volume.
Positive_regulation (induced) of Localization (release) of vasopressin in nucleus
3) Confidence 0.70 Published 1990 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 1982697 Disease Relevance 0.08 Pain Relevance 0.30
The present data show that microinjection of clonidine into NTS resulted in a significant attenuation of AVP secretion induced by hypovolemia in the rat.
Positive_regulation (induced) of Localization (secretion) of AVP associated with pressure volume 2 under development and clonidine
4) Confidence 0.70 Published 1990 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1982697 Disease Relevance 0.10 Pain Relevance 0.34
We conclude that AVP release into VSA extracellular fluids following intraperitoneal indomethacin is dependent upon the neuronal sequelae inherent to pyrogen-evoked fever and not nonspecific rises in body temperature.
Positive_regulation (dependent) of Localization (release) of AVP in neuronal associated with fever
5) Confidence 0.70 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8322966 Disease Relevance 0.18 Pain Relevance 0.25
Moreover, naloxone (0.5 mg/kg) significantly increased AVP secretion induced by intracerebroventricular injection of carbachol (10 ng).
Positive_regulation (increased) of Localization (secretion) of AVP associated with narcan and intracerebroventricular
6) Confidence 0.70 Published 1989 Journal Endocrinology Section Abstract Doc Link 2546748 Disease Relevance 0 Pain Relevance 0.73
Moreover, naloxone (0.5 mg/kg) significantly increased AVP secretion induced by intracerebroventricular injection of carbachol (10 ng).
Positive_regulation (induced) of Localization (secretion) of AVP associated with narcan and intracerebroventricular
7) Confidence 0.70 Published 1989 Journal Endocrinology Section Abstract Doc Link 2546748 Disease Relevance 0 Pain Relevance 0.73
Naloxone (0.5 mg/kg) significantly enhanced AVP secretion after 72-h water deprivation.
Positive_regulation (enhanced) of Localization (secretion) of AVP associated with narcan
8) Confidence 0.70 Published 1989 Journal Endocrinology Section Abstract Doc Link 2546748 Disease Relevance 0 Pain Relevance 0.64
These data suggested that it is through alpha-receptor rather than beta-receptor, NA induced PVN secretion of AVP that was delivered to the related brain regions to participate in pain modulation.
Positive_regulation (induced) of Localization (secretion) of AVP in PVN associated with pain
9) Confidence 0.70 Published 2009 Journal Neuropeptides Section Abstract Doc Link 19573913 Disease Relevance 0.66 Pain Relevance 0.85
Plasma AVP was decreased following hydration with 10 ml of water (1.0 +/- 0.3 pg/ml, mean +/- S.E.M.) as compared to controls (6.1 +/- 2.0 pg/ml), while withdrawal of water for 48 hours stimulated AVP release (29 +/- 8 pg/ml).
Positive_regulation (stimulated) of Localization (release) of AVP in Plasma associated with withdrawal
10) Confidence 0.70 Published 1981 Journal Acta Physiol. Scand. Section Abstract Doc Link 6753486 Disease Relevance 0.31 Pain Relevance 0.43
The data indicate that head-up tilt increases AVP secretion in anesthetized rats, that the response is mediated by the vagus and particularly by the arterial baroreceptors, and that circulating angiotensin II contributes to the response.
Positive_regulation (increases) of Localization (secretion) of AVP in head
11) Confidence 0.70 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1922676 Disease Relevance 0.06 Pain Relevance 0.05
Centrally released arginine vasopressin (AVP) has been implicated in the regulation of the brain water content and is elevated in the cerebrospinal fluid of patients with ischaemic and traumatic brain injuries.
Positive_regulation (elevated) of Localization (released) of AVP in brain associated with brain injury
12) Confidence 0.70 Published 1997 Journal Acta Neurochir (Wien) Section Abstract Doc Link 9479425 Disease Relevance 0.33 Pain Relevance 0.09
It is likely that steroid hormones mediate the action of enkephalin on vasopressin secretion in a specific manner.
Positive_regulation (mediate) of Localization (secretion) of vasopressin associated with enkephalin
13) Confidence 0.69 Published 1989 Journal Neuropeptides Section Abstract Doc Link 2472572 Disease Relevance 0.09 Pain Relevance 0.69
The absence or marked abatement of both baroreceptor impulses and adrenomedullary secretion were found necessary for secretion of vasopressin in pressor amounts: the vasopressin antagonist lowered arterial pressure in rats with sinoaortic denervation and ganglion blockade or adrenalectomy.
Positive_regulation (necessary) of Localization (secretion) of vasopressin in ganglion associated with ganglion cysts and antagonist
14) Confidence 0.69 Published 1983 Journal Jpn. J. Physiol. Section Abstract Doc Link 6674655 Disease Relevance 0.10 Pain Relevance 0.13
The increased release of both adrenaline and vasopressin (but not noradrenaline) after haemorrhage in the same animal is detected using this technique, and the importance of vasopressin to the normal recovery process confirmed.
Positive_regulation (increased) of Localization (release) of vasopressin associated with noradrenaline and cva
15) Confidence 0.69 Published 1990 Journal Pflugers Arch. Section Abstract Doc Link 2293200 Disease Relevance 0.81 Pain Relevance 0.24
These findings suggest that the central cholinergic stimulation of vasopressin release is due, in part, to activation of muscarinic receptors in the paraventricular nucleus and nicotinic receptors in the supraoptic nucleus.
Positive_regulation (stimulation) of Localization (release) of vasopressin in supraoptic nucleus
16) Confidence 0.69 Published 1992 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 1409734 Disease Relevance 0 Pain Relevance 0.21
The mechanisms leading to enhanced vasopressin secretion and the vascular consequences of the high plasma vasopressin levels during nicotine infusion have not yet been determined.
Positive_regulation (enhanced) of Localization (secretion) of vasopressin in plasma associated with nicotine
17) Confidence 0.69 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3681699 Disease Relevance 0 Pain Relevance 0.43
Nicotine-induced release of vasopressin in the conscious rat: role of opioid peptides and hemodynamic effects.
Positive_regulation (induced) of Localization (release) of vasopressin associated with nicotine and opioid
18) Confidence 0.69 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 3681699 Disease Relevance 0.06 Pain Relevance 0.70
Nicotine injected in the supraoptic nucleus facilitates vasopressin release from the neurohypophysis.
Positive_regulation (facilitates) of Localization (release) of vasopressin in neurohypophysis associated with nicotine
19) Confidence 0.69 Published 2001 Journal Neuroreport Section Abstract Doc Link 11234780 Disease Relevance 0 Pain Relevance 0.39
Vasopressin release after stimulation with 9% saline, however, was augmented in the lesioned animals.
Positive_regulation (augmented) of Localization (release) of Vasopressin
20) Confidence 0.69 Published 1983 Journal Endocrinology Section Abstract Doc Link 6861716 Disease Relevance 0.09 Pain Relevance 0.49

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