INT4360

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Context Info
Confidence 0.22
First Reported 1975
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 29
Total Number 29
Disease Relevance 38.10
Pain Relevance 4.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 3
ovary 3
plasma 2
pancreatic islet 1
liver 1
Hypism (Mus musculus)
Pain Link Frequency Relevance Heat
opiate 12 99.84 Very High Very High Very High
narcan 10 99.74 Very High Very High Very High
Opioid 11 99.36 Very High Very High Very High
withdrawal 4 98.76 Very High Very High Very High
allodynia 3 97.96 Very High Very High Very High
Inflammation 96 97.32 Very High Very High Very High
Chronic pancreatitis 4 95.20 Very High Very High Very High
Central nervous system 9 93.12 High High
Spinal cord 2 92.92 High High
antagonist 18 91.04 High High
Disease Link Frequency Relevance Heat
Obesity 467 100.00 Very High Very High Very High
Insulin Resistance 311 100.00 Very High Very High Very High
Targeted Disruption 279 100.00 Very High Very High Very High
Hyperinsulinism 150 100.00 Very High Very High Very High
Metabolic Syndrome 99 100.00 Very High Very High Very High
Hyperglycemia 35 100.00 Very High Very High Very High
Syndrome 26 100.00 Very High Very High Very High
Hyperphagia 16 100.00 Very High Very High Very High
Diabetes Mellitus 335 99.92 Very High Very High Very High
Polycystic Ovary Syndrome 35 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that the hyperinsulinemia, hyperphagia, and obesity in lethal yellow and viable yellow mice is caused primarily by agouti-induced antagonism of Mc4r in the hypothalamus, a center of autonomic regulatory control in the brain [35].
Gene_expression (obesity) of hyperinsulinemia in hypothalamus associated with hyperphagia, obesity and hyperinsulinism
1) Confidence 0.22 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 1.41 Pain Relevance 0.12
The hallmark of the metabolic syndrome appears to be hyperinsulinemia and insulin resistance (Prasad and Quyyumi 2004).
Gene_expression (resistance) of hyperinsulinemia associated with hyperinsulinism, metabolic syndrome and insulin resistance
2) Confidence 0.21 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 1.57 Pain Relevance 0.08
Remarkably, hyperinsulinemia and low blood glucose levels were also present in newborn and 1-wk-old ob/ob mice (Fig. 1, B and C).
Gene_expression (present) of hyperinsulinemia in blood associated with obesity and hyperinsulinism
3) Confidence 0.21 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.93 Pain Relevance 0
To understand how this marked hyperinsulinemia develops in mice that are otherwise metabolically normal, we studied islet gene expression and ?
Gene_expression (develops) of hyperinsulinemia associated with hyperinsulinism
4) Confidence 0.21 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.89 Pain Relevance 0
-cell proliferation in the adipocyte-deficient mice, the data presented here show that hyperinsulinemia and lower blood glucose levels precede the appearance of obesity and hyperglycemia in ob/ob and adipocyte-deficient mice, respectively, and can be ascribed in both cases to an increase in Insulin and Glucokinase expression and, to a lesser extent, to an increase in ?
Gene_expression (precede) of hyperinsulinemia in blood associated with hyperglycemia, obesity and hyperinsulinism
5) Confidence 0.21 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.85 Pain Relevance 0
To understand how this marked hyperinsulinemia develops in mice that are otherwise metabolically normal, we studied islet gene expression and ?
Gene_expression (marked) of hyperinsulinemia associated with hyperinsulinism
6) Confidence 0.21 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.89 Pain Relevance 0
The current investigations were undertaken to determine if agouti expression in the liver of transgenic mice could recapitulate any aspects of the dominant pleiotropic syndrome (i.e., obesity, hyperglycemia, hyperinsulinemia, and/or liver cancer) observed in lethal yellow and viable yellow mice.
Gene_expression (expression) of hyperinsulinemia in liver associated with liver cancer, hyperglycemia, targeted disruption, syndrome, obesity and hyperinsulinism
7) Confidence 0.20 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 1.34 Pain Relevance 0
Two-week high fat feeding induced hyperinsulinemia and severe hepatic and skeletal muscle insulin resistance in WT but not 12/15LO KO mice. 12/15LO KO mice exhibited significantly greater insulin-stimulated skeletal muscle Akt phosphorylation after HFD, compared to WT mice, corresponding to their greater insulin sensitivity.
Gene_expression (resistance) of hyperinsulinemia in skeletal muscle associated with targeted disruption, hyperinsulinism and insulin resistance
8) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2746280 Disease Relevance 2.04 Pain Relevance 0.27
HFD-fed 12/15LO KO mice did exhibit a similar fold increase in eWAT mass but not hyperinsulinemia, compared to HFD-fed WT mice (Table 1).
Gene_expression (mass) of hyperinsulinemia associated with targeted disruption and hyperinsulinism
9) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2746280 Disease Relevance 1.51 Pain Relevance 0.06
Type 2 diabetes is diagnosed in over 80% of individuals above the age of 16 while insulin resistance and hyperinsulinemia have been demonstrated in individuals as young as 1 year old, even prior to the onset of obesity [3,38].
Gene_expression (resistance) of hyperinsulinemia associated with diabetes mellitus, metabolic syndrome, hyperinsulinism and insulin resistance
10) Confidence 0.17 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2266715 Disease Relevance 2.14 Pain Relevance 0
Different clinical features of diabetes are associated with these two conditions: hyperinsulinemia and peripheral insulin resistance are the prevailing diabetic traits in pancreatic cancer, whereas reduced islet cell mass and impaired insulin secretion are typically observed in chronic pancreatitis.
Gene_expression (resistance) of hyperinsulinemia associated with diabetes mellitus, pancreatic cancer, hyperinsulinism, insulin resistance and chronic pancreatitis
11) Confidence 0.12 Published 2008 Journal Exp. Clin. Endocrinol. Diabetes Section Abstract Doc Link 18777459 Disease Relevance 1.49 Pain Relevance 0.19
Peripherally, opioids are involved in the regulation of pancreatic islet function, hepatic insulin clearance, and glucose metabolism, potentially contributing to the pathogenesis of hyperinsulinemia and insulin resistance in PCOS.
Gene_expression (resistance) of hyperinsulinemia in pancreatic islet
12) Confidence 0.07 Published 2009 Journal Fertil. Steril. Section Body Doc Link 19560572 Disease Relevance 0.16 Pain Relevance 0
Peripheral insulin resistance and hyperinsulinemia are the predominant diabetic traits in pancreatic cancer, while reduced islet cell mass and impaired insulin secretion are observed more often in chronic pancreatitis.
Gene_expression (resistance) of hyperinsulinemia associated with diabetes mellitus, pancreatic cancer, hyperinsulinism, insulin resistance and chronic pancreatitis
13) Confidence 0.07 Published 2009 Journal Pancreatology Section Abstract Doc Link 19299909 Disease Relevance 1.54 Pain Relevance 0.19
These include increasing age, increasing body mass index (BMI), hyperinsulinemia, insulin resistance, type 2 diabetes, and polycystic ovary syndrome.
Gene_expression (resistance) of hyperinsulinemia in ovary associated with diabetes mellitus, obesity, polycystic ovary syndrome, hyperinsulinism and insulin resistance
14) Confidence 0.07 Published 2002 Journal Am. J. Surg. Section Abstract Doc Link 12527345 Disease Relevance 1.21 Pain Relevance 0.09
Fasting hyperinsulinemia is also present early in the disease process and is thought to be a compensatory mechanism to maintain euglycemia in the setting of insulin resistance [148].
Gene_expression (present) of hyperinsulinemia associated with hyperinsulinism, insulin resistance and disease
15) Confidence 0.07 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.80 Pain Relevance 0
In young and middle age, adverse effects of hyperinsulinemia or insulin resistance on brain function are rare [70].
Gene_expression (resistance) of hyperinsulinemia in brain associated with hyperinsulinism and insulin resistance
16) Confidence 0.06 Published 2007 Journal BMC Evol Biol Section Body Doc Link PMC1868084 Disease Relevance 1.15 Pain Relevance 0
Chronic endogenous hyperinsulinemia produced by daily growth hormone treatment resulted in an insensitivity of the CNS glucoregulator center to exogenous insulin.
Gene_expression (produced) of hyperinsulinemia associated with hyperinsulinism
17) Confidence 0.05 Published 1975 Journal Diabetes Section Abstract Doc Link 1132600 Disease Relevance 0.19 Pain Relevance 0.34
Estrogen withdrawal in these animals also induces fasting and glucose-stimulated hyperinsulinemia, which are signs of worsening insulin resistance.
Gene_expression (resistance) of hyperinsulinemia associated with hyperinsulinism, insulin resistance and withdrawal
18) Confidence 0.04 Published 1996 Journal Am. J. Hypertens. Section Abstract Doc Link 8972891 Disease Relevance 0.73 Pain Relevance 0.27
One proposed mechanism is the rise of insulin resistance resulting in hyperinsulinemia that can cause growth-promoting effects [7].
Gene_expression (resistance) of hyperinsulinemia associated with hyperinsulinism and insulin resistance
19) Confidence 0.04 Published 2007 Journal Nutr J Section Body Doc Link PMC2018695 Disease Relevance 2.00 Pain Relevance 0
Hyperinsulinemia and insulin resistance in hypertension: differential effects of antihypertensive agents.
Gene_expression (resistance) of Hyperinsulinemia associated with hypertension, hyperinsulinism and insulin resistance
20) Confidence 0.04 Published 1999 Journal Clin. Exp. Hypertens. Section Title Doc Link 10052652 Disease Relevance 1.80 Pain Relevance 0.14

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