INT43637
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
As the PI3K-Akt pathway is involved in cell survival, proliferation, and migration, its activation through GAS6/AXL may be a common central biological event during the pathogenesis of endometriosis. | |||||||||||||||
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Furthermore, the proto-oncogenes AXL, SHC1, and JUND are elevated in endometriosis (Table 2). | |||||||||||||||
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Overexpression of both AXL and GAS6 in ovarian endometriosis has previously been demonstrated using RT-PCR analysis and IHC [44]. | |||||||||||||||
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IGF2, ACTN4, AXL, and SHC1 were among the most upregulated genes. | |||||||||||||||
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Such changes have been linked with oncogene activation in the instance of other tumors. | |||||||||||||||
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Our results suggest the following for RCC (1) Self-sufficiency in growth signals is achieved via activation of oncogenes JAZF1, AXL, ABL2; and growth factors INHBB and VGF. | |||||||||||||||
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Similar to what we observed for AXL, SHC1 was found consistently elevated in the studied endometriotic samples. | |||||||||||||||
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Their results suggested that some tumors activated the oncogene through chromosomal translocations that eliminated the oncogene's 3' untranslated region with the let-7 miRNA target sites [44]. | |||||||||||||||
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These data suggest that CBX7 may act as an oncogene in gastric cancer partially via regulation of p16(INK4a).
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This step is critical for Ras activation as an oncogene. | |||||||||||||||
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Inhibitors of the activated RET proto-oncogene and other RTK inhibitors appear particularly promising, based on the high prevalence of mutated oncogenes and specific expression patterns in MTC [2]. | |||||||||||||||
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