INT43637

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Context Info
Confidence 0.58
First Reported 1983
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 11.71
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (AXL) signal transduction (AXL) plasma membrane (AXL)
AXL (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 540 99.84 Very High Very High Very High
pain pelvic 10 76.00 Quite High
Analgesic 1 52.64 Quite High
antagonist 1 16.00 Low Low
Inflammation 5 14.20 Low Low
cytokine 6 5.00 Very Low Very Low Very Low
Dismenorea 5 5.00 Very Low Very Low Very Low
addiction 5 5.00 Very Low Very Low Very Low
Thalamus 5 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 320 99.98 Very High Very High Very High
Endometriosis 690 99.84 Very High Very High Very High
Stomach Cancer 55 99.84 Very High Very High Very High
Genetic Translocation 4 99.64 Very High Very High Very High
Renal Cancer 59 98.88 Very High Very High Very High
Thyroid Neoplasm 92 98.64 Very High Very High Very High
Disease 87 98.52 Very High Very High Very High
Lung Cancer 92 98.08 Very High Very High Very High
Chromosome Aberrations 13 97.40 Very High Very High Very High
Carcinoma 34 94.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As the PI3K-Akt pathway is involved in cell survival, proliferation, and migration, its activation through GAS6/AXL may be a common central biological event during the pathogenesis of endometriosis.
Positive_regulation (activation) of AXL associated with endometriosis
1) Confidence 0.58 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.82 Pain Relevance 0.24
Furthermore, the proto-oncogenes AXL, SHC1, and JUND are elevated in endometriosis (Table 2).
Positive_regulation (elevated) of AXL associated with endometriosis
2) Confidence 0.39 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.90 Pain Relevance 0.38
Overexpression of both AXL and GAS6 in ovarian endometriosis has previously been demonstrated using RT-PCR analysis and IHC [44].
Positive_regulation (Overexpression) of AXL associated with endometriosis
3) Confidence 0.39 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.91 Pain Relevance 0.27
IGF2, ACTN4, AXL, and SHC1 were among the most upregulated genes.
Positive_regulation (upregulated) of AXL
4) Confidence 0.39 Published 2008 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2615013 Disease Relevance 1.27 Pain Relevance 0.46
Such changes have been linked with oncogene activation in the instance of other tumors.
Positive_regulation (activation) of oncogene associated with cancer
5) Confidence 0.38 Published 1983 Journal Semin. Oncol. Section Abstract Doc Link 6320450 Disease Relevance 1.76 Pain Relevance 0.05
Our results suggest the following for RCC (1) Self-sufficiency in growth signals is achieved via activation of oncogenes JAZF1, AXL, ABL2; and growth factors INHBB and VGF.
Positive_regulation (activation) of AXL associated with renal cancer
6) Confidence 0.30 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.60 Pain Relevance 0
Similar to what we observed for AXL, SHC1 was found consistently elevated in the studied endometriotic samples.
Positive_regulation (elevated) of AXL associated with endometriosis
7) Confidence 0.17 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.79 Pain Relevance 0.19
Their results suggested that some tumors activated the oncogene through chromosomal translocations that eliminated the oncogene's 3' untranslated region with the let-7 miRNA target sites [44].
Positive_regulation (activated) of oncogene associated with genetic translocation and cancer
8) Confidence 0.01 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 1.16 Pain Relevance 0
These data suggest that CBX7 may act as an oncogene in gastric cancer partially via regulation of p16(INK4a).


Spec (may) Positive_regulation (act) of oncogene associated with stomach cancer
9) Confidence 0.01 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2933612 Disease Relevance 1.23 Pain Relevance 0
This step is critical for Ras activation as an oncogene.
Positive_regulation (activation) of oncogene
10) Confidence 0.01 Published 2003 Journal Respir Res Section Body Doc Link PMC314397 Disease Relevance 0.49 Pain Relevance 0
Inhibitors of the activated RET proto-oncogene and other RTK inhibitors appear particularly promising, based on the high prevalence of mutated oncogenes and specific expression patterns in MTC [2].
Positive_regulation (activated) of oncogene associated with thyroid neoplasm
11) Confidence 0.00 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 0.79 Pain Relevance 0

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