INT43637

Context Info Confidence 0.58 First Reported 1983 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 11 Total Number 11 Disease Relevance 11.71 Pain Relevance 1.59

cell differentiation (AXL) signal transduction (AXL) plasma membrane (AXL)

AXL (Homo sapiens)

Pain Link Frequency Relevance Heat endometriosis 540 99.84 pain pelvic 10 76.00 Analgesic 1 52.64 antagonist 1 16.00 Inflammation 5 14.20 cytokine 6 5.00 Dismenorea 5 5.00 addiction 5 5.00 Thalamus 5 5.00 palliative 3 5.00

Disease Link Frequency Relevance Heat Cancer 320 99.98 Endometriosis 690 99.84 Stomach Cancer 55 99.84 Genetic Translocation 4 99.64 Renal Cancer 59 98.88 Thyroid Neoplasm 92 98.64 Disease 87 98.52 Lung Cancer 92 98.08 Chromosome Aberrations 13 97.40 Carcinoma 34 94.68

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

As the PI3K-Akt pathway is involved in cell survival, proliferation, and migration, its activation through GAS6/AXL may be a common central biological event during the pathogenesis of endometriosis.

Positive_regulation (activation) of AXL associated with endometriosis

1) Confidence 0.58 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.82 Pain Relevance 0.24

Furthermore, the proto-oncogenes AXL, SHC1, and JUND are elevated in endometriosis (Table 2).

Positive_regulation (elevated) of AXL associated with endometriosis

2) Confidence 0.39 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.90 Pain Relevance 0.38

Overexpression of both AXL and GAS6 in ovarian endometriosis has previously been demonstrated using RT-PCR analysis and IHC [44].

Positive_regulation (Overexpression) of AXL associated with endometriosis

3) Confidence 0.39 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.91 Pain Relevance 0.27

IGF2, ACTN4, AXL, and SHC1 were among the most upregulated genes.

Positive_regulation (upregulated) of AXL

4) Confidence 0.39 Published 2008 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2615013 Disease Relevance 1.27 Pain Relevance 0.46

Such changes have been linked with oncogene activation in the instance of other tumors.

Positive_regulation (activation) of oncogene associated with cancer

5) Confidence 0.38 Published 1983 Journal Semin. Oncol. Section Abstract Doc Link 6320450 Disease Relevance 1.76 Pain Relevance 0.05

Our results suggest the following for RCC (1) Self-sufficiency in growth signals is achieved via activation of oncogenes JAZF1, AXL, ABL2; and growth factors INHBB and VGF.

Positive_regulation (activation) of AXL associated with renal cancer

6) Confidence 0.30 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.60 Pain Relevance 0

Similar to what we observed for AXL, SHC1 was found consistently elevated in the studied endometriotic samples.

Positive_regulation (elevated) of AXL associated with endometriosis

7) Confidence 0.17 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.79 Pain Relevance 0.19

Their results suggested that some tumors activated the oncogene through chromosomal translocations that eliminated the oncogene's 3' untranslated region with the let-7 miRNA target sites [44].

Positive_regulation (activated) of oncogene associated with genetic translocation and cancer

8) Confidence 0.01 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 1.16 Pain Relevance 0

These data suggest that CBX7 may act as an oncogene in gastric cancer partially via regulation of p16(INK4a).

Spec (may) Positive_regulation (act) of oncogene associated with stomach cancer

9) Confidence 0.01 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2933612 Disease Relevance 1.23 Pain Relevance 0

This step is critical for Ras activation as an oncogene.

Positive_regulation (activation) of oncogene

10) Confidence 0.01 Published 2003 Journal Respir Res Section Body Doc Link PMC314397 Disease Relevance 0.49 Pain Relevance 0

Inhibitors of the activated RET proto-oncogene and other RTK inhibitors appear particularly promising, based on the high prevalence of mutated oncogenes and specific expression patterns in MTC [2].

Positive_regulation (activated) of oncogene associated with thyroid neoplasm

11) Confidence 0.00 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 0.79 Pain Relevance 0

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