INT43642

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Context Info
Confidence 0.41
First Reported 1984
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.70
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc12a3) transport (Slc12a3) plasma membrane (Slc12a3)
transmembrane transport (Slc12a3)
Anatomy Link Frequency
brain 1
ascending limb 1
Slc12a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 3 98.32 Very High Very High Very High
antagonist 7 93.40 High High
opiate 3 92.92 High High
agonist 3 79.04 Quite High
anesthesia 4 64.80 Quite High
narcan 1 25.00 Low Low
Immobilon 1 25.00 Low Low
isoflurane 4 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
bradykinin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 11 90.12 High High
Chronic Renal Failure 124 81.28 Quite High
Natriuresis 2 75.28 Quite High
Uremia 4 5.00 Very Low Very Low Very Low
Fibrosis 1 5.00 Very Low Very Low Very Low
Disorders Of Creatine Metabolism 1 5.00 Very Low Very Low Very Low
Bartter Syndrome 1 5.00 Very Low Very Low Very Low
Hypercalcemia 1 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NCC abundance is increased during dietary NaCl restriction and by aldosterone and decreased during a high-salt (HS) diet and mineralocorticoid blockade.
Positive_regulation (increased) of NCC
1) Confidence 0.41 Published 2006 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 16554416 Disease Relevance 0 Pain Relevance 0.06
Furthermore, they also explain why good yields of binding to the soluble opioid binding sites from toad brain can be obtained in the absence of sodium, while high concentrations of NaCl are required for mammalian brain, such as rat.
Positive_regulation (concentrations) of NaCl in brain associated with opioid
2) Confidence 0.13 Published 1984 Journal Brain Res. Section Abstract Doc Link 6320961 Disease Relevance 0 Pain Relevance 0.76
In contrast, the densities per nephron of both rat type 1 bumetanide-sensitive Na-K-2Cl cotransporter (BSC-1) in the thick ascending limb (TAL) and thiazide-sensitive Na-Cl cotransporter (TSC) in the distal convoluted tubule (DCT) were significantly increased.
Positive_regulation (increased) of TSC in ascending limb
3) Confidence 0.12 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.70 Pain Relevance 0

General Comments

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