INT43648

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Context Info
Confidence 0.50
First Reported 1984
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.24
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mme) plasma membrane (Mme)
Mme (Rattus norvegicus)
Pain Link Frequency Relevance Heat
addiction 2 99.56 Very High Very High Very High
antagonist 4 99.18 Very High Very High Very High
Potency 6 97.84 Very High Very High Very High
Neurotransmitter 1 92.40 High High
Dopamine 2 89.80 High High
methadone 3 88.00 High High
Nucleus accumbens 1 76.84 Quite High
alcohol 6 73.84 Quite High
Enkephalin 2 71.36 Quite High
Analgesic 2 59.36 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 1 99.56 Very High Very High Very High
Reprotox - General 2 2 79.68 Quite High
Alcohol Addiction 1 60.12 Quite High
Opiate Addiction 1 49.84 Quite Low
Recurrence 2 0.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite the similarities in their mechanism of action, the structural requirements for selective interaction with angiotensin-converting enzyme or enkephalinase are different.
Positive_regulation (requirements) of enkephalinase Binding (interaction) of
1) Confidence 0.50 Published 1984 Journal Eur. J. Biochem. Section Abstract Doc Link 6321177 Disease Relevance 0 Pain Relevance 0.12
This feature could mean that optimal binding of the Zn atom present in the catalytic site is a more stringent requirement in angiotensin-converting enzyme than in enkephalinase.
Positive_regulation (requirement) of enkephalinase Binding (binding) of
2) Confidence 0.43 Published 1984 Journal Eur. J. Biochem. Section Abstract Doc Link 6321177 Disease Relevance 0.08 Pain Relevance 0.24
Narcotic antagonists in drug dependence: pilot study showing enhancement of compliance with SYN-10, amino-acid precursors and enkephalinase inhibition therapy.
Positive_regulation (enhancement) of enkephalinase Binding (compliance) of associated with drug dependence, addiction and antagonist
3) Confidence 0.23 Published 2004 Journal Med. Hypotheses Section Title Doc Link 15288384 Disease Relevance 0.16 Pain Relevance 0.58

General Comments

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