INT4365

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Context Info
Confidence 0.29
First Reported 1975
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 2.18
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
External 1
Hc3 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 2 95.80 Very High Very High Very High
lidocaine 3 82.72 Quite High
local anesthetic 5 75.00 Quite High
Neurotransmitter 1 70.64 Quite High
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 25 100.00 Very High Very High Very High
Sarcoma 70 94.72 High High
Cancer 185 92.12 High High
Metastasis 80 89.12 High High
Skin Cancer 15 81.16 Quite High
Reprotox - General 1 5 54.24 Quite High
Breast Cancer 5 49.44 Quite Low
Fibrosarcoma 5 26.60 Quite Low
Stress 10 17.88 Low Low
Severe Combined Immunodeficiency 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In agreement with this, preliminary findings indicate a progressive increase in the expression of pro-angiogenic factors (such as VEGF and FGF2) and a concomitant decrease of angiogenesis-inhibitory factors (particularly TSP-1 and TSP-2) during cen3tel malignant progression, pointing to angiogenesis as a candidate pro-metastatic feature acquired by late-phase metastatic cen3tel cells.
Gene_expression (progression) of cen3tel associated with malignant neoplastic disease
1) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.76 Pain Relevance 0
Rnd3 expression inversely correlates with the invasive and metastatic properties of tumorigenic cen3tel cell
Gene_expression (cell) of cen3tel
2) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0 Pain Relevance 0
In agreement with this, preliminary findings indicate a progressive increase in the expression of pro-angiogenic factors (such as VEGF and FGF2) and a concomitant decrease of angiogenesis-inhibitory factors (particularly TSP-1 and TSP-2) during cen3tel malignant progression, pointing to angiogenesis as a candidate pro-metastatic feature acquired by late-phase metastatic cen3tel cells.
Gene_expression (expression) of cen3tel associated with malignant neoplastic disease
3) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.93 Pain Relevance 0
Our observation that ectopic Rnd3 expression in phase II and III tumorigenic cen3tel cells reduced their invasive capacity points to Rnd3 as a possible regulator of invasion of cells of mesenchymal origin.
Gene_expression (expression) of cen3tel
4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.28 Pain Relevance 0
Global gene expression profiling of cen3tel cells at different PDs showed a decrease in the expression of different types of extra-cellular matrix proteases during cen3tel propagation in vitro, particularly of several matrix-metalloproteases (MMPs) (Table 1), and zymographic analysis showed a decrease in the activity of MMP2 and MMP9 in tumorigenic cen3tel cells (data not shown), suggesting that increased motility in late cen3tel cells was not strictly dependent on pericellular matrix proteolysis.
Gene_expression (expression) of cen3tel
5) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.21 Pain Relevance 0
NIH3T3ChAT 112-1 cells showed increased binding of the CHT1 inhibitor [(3)H]hemicholinium-3 (HC-3) and greater [(3)H]choline uptake and ACh synthesis than NIH3T3ChAT 103-1 cells, a CHT1-negative control cell line.
Gene_expression (synthesis) of HC-3
6) Confidence 0.13 Published 2009 Journal J. Neurosci. Res. Section Abstract Doc Link 19405101 Disease Relevance 0 Pain Relevance 0.17
Hemicholinium-3 (HC-3), on the other hand, which exists only in the charged form, caused a large stimulation of the 45-Ca efflux following microinjection, and the potency of this action was found to be at least 10 times greater than that of procaine.
Gene_expression (exists) of HC-3 associated with potency
7) Confidence 0.11 Published 1975 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 1137823 Disease Relevance 0 Pain Relevance 0.19
External application of HC-3 produced inhibition occasionally.
Gene_expression (produced) of HC-3 in External
8) Confidence 0.10 Published 1975 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 1137823 Disease Relevance 0 Pain Relevance 0.26

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