INT43662

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Context Info
Confidence 0.01
First Reported 1984
Last Reported 1984
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.73

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cytoplasm (Chrna7, Rac1) plasma membrane (Chrna7, Rac1) intracellular (Rac1)
enzyme binding (Rac1) GTPase activity (Rac1) cell proliferation (Rac1)
Chrna7 (Rattus norvegicus)
Rac1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
local anesthetic 10 100.00 Very High Very High Very High
sodium channel 4 96.36 Very High Very High Very High
lidocaine 2 71.84 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A 7-fold difference in KD for inhibition of [3H]BTX-B binding between the local anesthetic stereoisomers RAC 109 I and RAC 109 II was observed.
Negative_regulation (inhibition) of BTX-B Binding (binding) of RAC 109 I associated with local anesthetic
1) Confidence 0.01 Published 1984 Journal Mol. Pharmacol. Section Abstract Doc Link 6321944 Disease Relevance 0 Pain Relevance 0.73

General Comments

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