INT4369

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Context Info
Confidence 0.76
First Reported 1975
Last Reported 2011
Negated 5
Speculated 5
Reported most in Abstract
Documents 157
Total Number 162
Disease Relevance 88.12
Pain Relevance 22.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ldha) mitochondrion (Ldha) oxidoreductase activity (Ldha)
cytoplasm (Ldha)
Anatomy Link Frequency
liver 6
hepatocytes 6
WBC 5
CAR 4
muscle 3
Ldha (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 239 100.00 Very High Very High Very High
spinal dorsal horn 190 100.00 Very High Very High Very High
Nerve growth factor 159 100.00 Very High Very High Very High
Spinal cord 108 100.00 Very High Very High Very High
cytokine 103 100.00 Very High Very High Very High
agonist 96 100.00 Very High Very High Very High
Angina 47 100.00 Very High Very High Very High
Dorsal horn 46 100.00 Very High Very High Very High
adenocard 34 100.00 Very High Very High Very High
Fibrositis 7 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 364 100.00 Very High Very High Very High
Nicotine Addiction 53 100.00 Very High Very High Very High
Angina 19 100.00 Very High Very High Very High
Disorders Of Creatine Metabolism 19 100.00 Very High Very High Very High
Dyspnea 10 100.00 Very High Very High Very High
Weight Loss 6 100.00 Very High Very High Very High
Fibromyalgia 5 100.00 Very High Very High Very High
Thyroid Disease 3 100.00 Very High Very High Very High
Hypoxia 540 99.96 Very High Very High Very High
Diabetes Mellitus 823 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After incubation of 2 h or 4 h, cell morphology was observed and endocellular superoxide dismutase (SOD), endocellular malondialdehyde (MDA), lactate dehydrogenase (LDH) leaking ratio, and dead cells' percentage were detected.
Gene_expression (detected) of lactate dehydrogenase
1) Confidence 0.76 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18577417 Disease Relevance 0.07 Pain Relevance 0.07
After incubation of 2 h or 4 h, cell morphology was observed and endocellular superoxide dismutase (SOD), endocellular malondialdehyde (MDA), lactate dehydrogenase (LDH) leaking ratio, and dead cells' percentage were detected.
Gene_expression (detected) of LDH
2) Confidence 0.76 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18577417 Disease Relevance 0.07 Pain Relevance 0.07
Pentobarbital anesthesia produced only slightly lower activities, per gram DNA, of LDH, acid phosphatase, and glutamic-DH in cortical bone.
Gene_expression (produced) of LDH in cortical bone associated with anesthesia
3) Confidence 0.76 Published 1975 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 1139446 Disease Relevance 0.17 Pain Relevance 0.35
The suppression of LDH release was observed even when isoflurane was administered during the reperfusion period, but not when it was administered only during ischemia.
Gene_expression (suppression) of LDH
4) Confidence 0.68 Published 1996 Journal Acta Anaesthesiol Scand Section Body Doc Link 8986190 Disease Relevance 0.11 Pain Relevance 0
The acetaminophen-induced GSH depletion and ensuing lactate dehydrogenase (LDH) leakage were quite modest and delayed in onset, in contrast to that caused by iodoacetamide (IAA) and by diethylmaleate (DEM), 2 well-known depletors of GSH.
Gene_expression (depletion) of LDH associated with paracetamol
5) Confidence 0.66 Published 1985 Journal Toxicology Section Abstract Doc Link 4060164 Disease Relevance 0 Pain Relevance 0.42
The acetaminophen-induced GSH depletion and ensuing lactate dehydrogenase (LDH) leakage were quite modest and delayed in onset, in contrast to that caused by iodoacetamide (IAA) and by diethylmaleate (DEM), 2 well-known depletors of GSH.
Gene_expression (depletion) of lactate dehydrogenase associated with paracetamol
6) Confidence 0.66 Published 1985 Journal Toxicology Section Abstract Doc Link 4060164 Disease Relevance 0 Pain Relevance 0.42
RESULTS: Urinary levels of GGT, ALP and LDH enzymes were significantly higher (P<0.05) at T(24) when compared to the levels at T(0) and returned to basal levels at T(48) and T(72).
Gene_expression (levels) of LDH
7) Confidence 0.61 Published 2006 Journal Clin. Chim. Acta Section Body Doc Link 16806140 Disease Relevance 0.13 Pain Relevance 0
The neuronal cell degeneration was Ca+(+)-dependent because, in the absence of extracellular Ca++, 16 hr of exposure to 30 microM veratridine failed to produce release of LDH.
Neg (failed) Gene_expression (produce) of LDH in neuronal
8) Confidence 0.60 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2175795 Disease Relevance 0.09 Pain Relevance 0.35
The cell morphology, lactate dehydrogenase (LDH) leakage, lipid peroxidation, GSH concentration, GSH peroxidase, GSH reductase (GRd), and GSH S-transferase activities were measured after irradiation.
Gene_expression (measured) of LDH
9) Confidence 0.60 Published 2003 Journal J. Formos. Med. Assoc. Section Body Doc Link 14517587 Disease Relevance 0 Pain Relevance 0
The cell morphology, lactate dehydrogenase (LDH) leakage, lipid peroxidation, GSH concentration, GSH peroxidase, GSH reductase (GRd), and GSH S-transferase activities were measured after irradiation.
Gene_expression (measured) of lactate dehydrogenase
10) Confidence 0.60 Published 2003 Journal J. Formos. Med. Assoc. Section Body Doc Link 14517587 Disease Relevance 0 Pain Relevance 0
Their viability was measured by the trypan blue dye exclusion method, and alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) levels in the preservation solution were measured.
Gene_expression (levels) of lactate dehydrogenase
11) Confidence 0.57 Published 2007 Journal J Hepatobiliary Pancreat Surg Section Body Doc Link 17909722 Disease Relevance 0.09 Pain Relevance 0
The levels of ALT and LDH in the preservation solution with DADLE were significantly lower than those in the preservation solution without DADLE.
Gene_expression (levels) of LDH
12) Confidence 0.57 Published 2007 Journal J Hepatobiliary Pancreat Surg Section Body Doc Link 17909722 Disease Relevance 0.08 Pain Relevance 0
Their viability was measured by the trypan blue dye exclusion method, and alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) levels in the preservation solution were measured.
Gene_expression (levels) of LDH
13) Confidence 0.57 Published 2007 Journal J Hepatobiliary Pancreat Surg Section Body Doc Link 17909722 Disease Relevance 0.09 Pain Relevance 0
Indices of toxicity determined included contractility, morphology, lactate dehydrogenase release (LDH), mitochondrial tetrazolium formazan (MTT) production and neutral red (NR) formation.
Gene_expression (production) of lactate dehydrogenase associated with toxicity
14) Confidence 0.57 Published 1992 Journal Toxicology Section Abstract Doc Link 1566279 Disease Relevance 0.27 Pain Relevance 0.43
Indices of toxicity determined included contractility, morphology, lactate dehydrogenase release (LDH), mitochondrial tetrazolium formazan (MTT) production and neutral red (NR) formation.
Gene_expression (production) of LDH associated with toxicity
15) Confidence 0.57 Published 1992 Journal Toxicology Section Abstract Doc Link 1566279 Disease Relevance 0.26 Pain Relevance 0.43
The following pretreatment characteristics were evaluated in both univariate and multivariate Cox regression analyses: age, gender, Karnofsky performance score (KPS), histology asbestos exposure, presence of chest pain, dyspnoea, weight loss, symptom duration, smoking history, disease location, platelet count, haemoglobin, white blood cell (WBC) count, serum lactate dehydrogenase (LDH) and extent of disease (stage).
Gene_expression (age) of serum lactate dehydrogenase in WBC associated with angina, nicotine addiction, weight loss, disease and dyspnea
16) Confidence 0.57 Published 2001 Journal Respir Med Section Abstract Doc Link 11601750 Disease Relevance 1.35 Pain Relevance 0.10
The following pretreatment characteristics were evaluated in both univariate and multivariate Cox regression analyses: age, gender, Karnofsky performance score (KPS), histology asbestos exposure, presence of chest pain, dyspnoea, weight loss, symptom duration, smoking history, disease location, platelet count, haemoglobin, white blood cell (WBC) count, serum lactate dehydrogenase (LDH) and extent of disease (stage).
Gene_expression (age) of LDH in WBC associated with angina, nicotine addiction, weight loss, disease and dyspnea
17) Confidence 0.57 Published 2001 Journal Respir Med Section Abstract Doc Link 11601750 Disease Relevance 1.35 Pain Relevance 0.10
The following pretreatment characteristics were evaluated in both univariate and multivariate Cox regression analyses: age, gender, Karnofsky performance score (KPS), histology asbestos exposure, presence of chest pain, dyspnoea, weight loss, symptom duration, smoking history, disease location, platelet count, haemoglobin, white blood cell (WBC) count, serum lactate dehydrogenase (LDH) and extent of disease (stage).
Gene_expression (evaluated) of LDH in WBC associated with angina, nicotine addiction, weight loss, disease and dyspnea
18) Confidence 0.57 Published 2001 Journal Respir Med Section Abstract Doc Link 11601750 Disease Relevance 1.36 Pain Relevance 0.10
The following pretreatment characteristics were evaluated in both univariate and multivariate Cox regression analyses: age, gender, Karnofsky performance score (KPS), histology asbestos exposure, presence of chest pain, dyspnoea, weight loss, symptom duration, smoking history, disease location, platelet count, haemoglobin, white blood cell (WBC) count, serum lactate dehydrogenase (LDH) and extent of disease (stage).
Gene_expression (evaluated) of serum lactate dehydrogenase in WBC associated with angina, nicotine addiction, weight loss, disease and dyspnea
19) Confidence 0.57 Published 2001 Journal Respir Med Section Abstract Doc Link 11601750 Disease Relevance 1.36 Pain Relevance 0.10
A combined index comprising LDH levels, C reactive protein levels, uric acid levels, presence of moderate to severe pain, fatigue, hypotension and performance status demonstrated a good stratification value for predicting survival time.
Gene_expression (levels) of LDH associated with pain, pressure volume 2 under development and fatigue
20) Confidence 0.56 Published 2007 Journal Eur. J. Cancer Section Abstract Doc Link 17349786 Disease Relevance 0.71 Pain Relevance 0.10

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