INT43707

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Context Info
Confidence 0.07
First Reported 1984
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 8.22
Pain Relevance 4.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CCBE1)
Anatomy Link Frequency
cerebrospinal fluid 11
CCBE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 10 99.98 Very High Very High Very High
cva 13 99.90 Very High Very High Very High
Spinal cord 3 99.84 Very High Very High Very High
epidural 1 99.78 Very High Very High Very High
Lasting pain 3 99.64 Very High Very High Very High
intrathecal 6 98.88 Very High Very High Very High
Multiple sclerosis 19 98.80 Very High Very High Very High
Cancer pain 1 97.52 Very High Very High Very High
Pain score 1 97.36 Very High Very High Very High
Pain 14 95.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hemorrhage 8 99.90 Very High Very High Very High
Cyst 1 99.80 Very High Very High Very High
Pain 16 99.64 Very High Very High Very High
Limbic Encephalitis 2 99.56 Very High Very High Very High
Pneumocephalus 7 99.08 Very High Very High Very High
Herpes Simplex Virus Infection 3 99.04 Very High Very High Very High
Myxoma 20 98.94 Very High Very High Very High
Demyelinating Disease 20 98.80 Very High Very High Very High
Recurrence 10 98.04 Very High Very High Very High
Cancer Pain 1 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Laboratory analyses showed elevated erythrocyte sedimentation rate (130/h), moderately elevated cerebrospinal fluid (CSF) protein level and mildly elevated CSF cell content.
Positive_regulation (elevated) of cerebrospinal fluid in CSF
1) Confidence 0.07 Published 1997 Journal Srp Arh Celok Lek Section Abstract Doc Link 17974356 Disease Relevance 1.05 Pain Relevance 0.29
Increased cerebrospinal fluid (CSF) levels of metenkephalin were correlated with the decreased pain scores.
Positive_regulation (Increased) of cerebrospinal fluid in cerebrospinal fluid associated with pain score
2) Confidence 0.05 Published 1999 Journal FASEB J. Section Abstract Doc Link 10619143 Disease Relevance 0.59 Pain Relevance 0.95
This 78-year-old man had undergone VP shunt insertion 3 weeks before readmission to the hospital with a diagnosis of TPC, a left temporal porencephalic cyst, and air accumulation and late leakage of cerebrospinal fluid (CSF) into the left tympanic cavity.
Positive_regulation (accumulation) of cerebrospinal fluid in cerebrospinal fluid associated with pneumocephalus and cyst
3) Confidence 0.03 Published 2007 Journal J. Neurosurg. Section Abstract Doc Link 17564188 Disease Relevance 0.63 Pain Relevance 0
Elevated cerebrospinal fluid (CSF) protein and diffuse leptomeningeal enhancement of the neuraxis from the cortical sulci to the cauda equina on contrast MRI were the defining clinical features.
Positive_regulation (Elevated) of cerebrospinal fluid in cerebrospinal fluid
4) Confidence 0.02 Published 2008 Journal J. Neurol. Sci. Section Abstract Doc Link 18579156 Disease Relevance 0.69 Pain Relevance 0.18
Epidural clonidine increases acetylcholine (ACh) concentrations in cerebrospinal fluid (CSF) in humans, and experiments in animals support a cholinergic link in spinal alpha2-adrenoceptor-mediated antinociception.
Positive_regulation (increases) of cerebrospinal fluid in cerebrospinal fluid associated with antinociception, epidural and clonidine
5) Confidence 0.02 Published 1997 Journal Anesth. Analg. Section Abstract Doc Link 9085961 Disease Relevance 0.07 Pain Relevance 0.72
beta-Endorphin-like immunoreactivity increases in human lumbar cerebrospinal fluid following routine metrizamide myelography.
Positive_regulation (increases) of cerebrospinal fluid in cerebrospinal fluid
6) Confidence 0.01 Published 1984 Journal J. Neurosurg. Section Title Doc Link 6323647 Disease Relevance 0.09 Pain Relevance 0.32
We report two cases of non-herpetic acute limbic encephalitis (NHALE) which showed elevation of interleukin (IL)-6 in the cerebrospinal fluid (CSF).
Positive_regulation (elevation) of cerebrospinal fluid in CSF associated with limbic encephalitis and herpes simplex virus infection
7) Confidence 0.01 Published 2003 Journal Rinsho Shinkeigaku Section Abstract Doc Link 12884825 Disease Relevance 0.89 Pain Relevance 0.13
[A case of cardiac myxoma presenting with multiple cerebellar hemorrhages and elevation of interleukin-6 in the cerebrospinal fluid].
Positive_regulation (elevation) of cerebrospinal fluid in cerebrospinal fluid associated with myxoma and cva
8) Confidence 0.01 Published 2004 Journal Rinsho Shinkeigaku Section Title Doc Link 15568483 Disease Relevance 1.24 Pain Relevance 0.36
We report a 25-year old man with cardiac myxoma presenting with multiple cerebellar hemorrhages and elevation of interleukin-6 (IL-6) in the cerebrospinal fluid (CSF).
Positive_regulation (elevation) of cerebrospinal fluid in CSF associated with myxoma and cva
9) Confidence 0.01 Published 2004 Journal Rinsho Shinkeigaku Section Abstract Doc Link 15568483 Disease Relevance 0.90 Pain Relevance 0.31
Plasmacytoid dendritic cells are increased in cerebrospinal fluid of untreated patients during multiple sclerosis relapse

The plasmacytoid dendritic cells (pDCs) express a high level of Toll-like receptor 9 (TLR-9), which recognizes viral DNA.

Positive_regulation (increased) of cerebrospinal fluid in cerebrospinal fluid associated with multiple sclerosis and recurrence
10) Confidence 0.01 Published 2011 Journal J Neuroinflammation Section Title Doc Link PMC3022734 Disease Relevance 0.98 Pain Relevance 0.25
Intrathecal AD-h-IL10 injected over lumbosacral spinal cord led to elevated lumbosacral cerebrospinal fluid (CSF) levels of human IL-10, with far less human IL-10 observed in cervical CSF.
Positive_regulation (elevated) of cerebrospinal fluid in CSF associated with spinal cord and intrathecal
11) Confidence 0.01 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15869510 Disease Relevance 1.09 Pain Relevance 1.35

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