INT43719

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Context Info
Confidence 0.69
First Reported 1984
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 5.15
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Vegfa) extracellular space (Vegfa) growth (Vegfa)
extracellular region (Vegfa) cytoplasm (Vegfa)
Anatomy Link Frequency
brain 2
heart 2
neurons 1
paw 1
fibroblast 1
Vegfa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 7 100.00 Very High Very High Very High
chemokine 24 99.74 Very High Very High Very High
ischemia 15 99.28 Very High Very High Very High
Pain 15 98.88 Very High Very High Very High
Inflammation 63 98.24 Very High Very High Very High
rheumatoid arthritis 1 97.04 Very High Very High Very High
dexamethasone 17 96.08 Very High Very High Very High
depression 32 92.80 High High
lidocaine 8 92.00 High High
antidepressant 31 91.92 High High
Disease Link Frequency Relevance Heat
Adhesions 12 99.36 Very High Very High Very High
Cv Unclassified Under Development 13 99.28 Very High Very High Very High
Disease 20 99.04 Very High Very High Very High
Rheumatoid Arthritis 46 98.40 Very High Very High Very High
INFLAMMATION 73 98.24 Very High Very High Very High
Cancer 26 97.84 Very High Very High Very High
Renal Disease 12 97.80 Very High Very High Very High
Necrosis 4 97.60 Very High Very High Very High
Amyloid Plaque 6 97.56 Very High Very High Very High
Pressure And Volume Under Development 5 96.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphologic and ultrastructural changes associated with ischemia including hypervascularization and increased vascular endothelial growth factor release were identified in painful patellofemoral malalignment.
Positive_regulation (increased) of vascular endothelial growth factor associated with pain and ischemia
1) Confidence 0.69 Published 2005 Journal Orthopedics Section Abstract Doc Link 16138473 Disease Relevance 0.35 Pain Relevance 0.39
The increase occurred in the amount of capillaries can be explained by the increase in the vascular endothelial growth factor.
Positive_regulation (increase) of vascular endothelial growth factor
2) Confidence 0.37 Published 2008 Journal J Cardiothorac Surg Section Body Doc Link PMC2459181 Disease Relevance 0.39 Pain Relevance 0
RESULTS: Ischemia led to strong upregulation of mRNA transcripts for heat shock proteins 70, 27, 105, 86 and 40 kDa, vascular endothelial growth factor, brain-derived neurotrophic factor, plasminogen activator inhibitor-1, activating transcription factor 3, B-cell translocation gene 2, and growth arrest and DNA damage inducible 45 alpha protein compared to the NI tissue.
Positive_regulation (upregulation) of vascular endothelial growth factor in brain
3) Confidence 0.36 Published 2003 Journal Cardiovasc. Res. Section Body Doc Link 12909328 Disease Relevance 0.15 Pain Relevance 0
Contrasting with most adult CNS neurons, hypothalamic magnocellular neurons were found to express vascular endothelial growth factor (VEGF), a potent angiogenic factor whose production was increased by osmotic stimulus.
Positive_regulation (increased) of vascular endothelial growth factor in neurons
4) Confidence 0.33 Published 2005 Journal BMC Neurosci Section Abstract Doc Link PMC1079868 Disease Relevance 0.06 Pain Relevance 0.05
It has been also recognized as an angiogenic chemokine through the induction of VEGF (vascular endothelial growth factor) -A gene expression [21].
Positive_regulation (induction) of vascular endothelial growth factor associated with chemokine
5) Confidence 0.25 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.47 Pain Relevance 0.50
Tarnawski et al. [28] previously reported that rebamipide significantly upregulated the proangiogenic genes encoding vascular endothelial growth factor (VEGF), heparin binding epidermal growth-like factor (HB-EGF), fibroblast growth factor receptor-2 (FGFR2), and cyclooxygenase-2 (Cox2), as well as growth promoting genes, including insulin growth factor-1 (IGF-1).
Positive_regulation (upregulated) of vascular endothelial growth factor in fibroblast
6) Confidence 0.22 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2243244 Disease Relevance 0.32 Pain Relevance 0.07
Bone marrow cells implantation induced angiogenesis in a rat ischemic heart model as a result of increase of the levels of vascular endothelial growth factor, vascular cell adhesion molecule, interleukin-1, and tumor necrosis factor-?.



Positive_regulation (increase) of vascular endothelial growth factor in heart associated with necrosis, cancer and adhesions
7) Confidence 0.20 Published 2008 Journal J Cardiothorac Surg Section Abstract Doc Link PMC2414821 Disease Relevance 0.79 Pain Relevance 0.16
The search for mechanisms of action has mostly focused on the involvement of molecular pathways, including the activation of specific serotonin receptors [9], [10], [11], the cAMP-CREB signaling pathway [12], and neurotrophins, particularly brain-derived neurotrophic factor (BDNF), fibroblast growth factor (FGF-2) and vascular endothelial growth factor (VEGF) [13].
Positive_regulation (activation) of vascular endothelial growth factor in brain associated with serotonin
8) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799663 Disease Relevance 0.60 Pain Relevance 0.50
Interestingly, activation of Shh signaling caused upregulation of pro-angiogenic growth factors including vascular endothelial growth factor (VEGF) and angiopoietin-1 which resulted in an increased angiogenic response and globally improved the heart function.
Positive_regulation (upregulation) of vascular endothelial growth factor in heart
9) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.29 Pain Relevance 0.04
Anti-inflammatory effects of polyamines in serotonin and carrageenan paw edemata - possible mechanism to increase vascular permeability inhibitory protein level which is regulated by glucocorticoids and superoxide radical.
Positive_regulation (increase) of vascular permeability inhibitory protein in paw associated with inflammation and serotonin
10) Confidence 0.08 Published 1984 Journal Agents Actions Section Title Doc Link 6324559 Disease Relevance 0.41 Pain Relevance 0.40
In anesthetized rats, the cyclooxygenase (COX) inhibitor indomethacin induces duodenal motility, increases duodenal mucosal alkaline secretion (DMAS), and evokes a transient increase in duodenal paracellular permeability (DPP).
Positive_regulation (increase) of permeability
11) Confidence 0.02 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11668025 Disease Relevance 0 Pain Relevance 0.35
The dramatic increases of BBB permeability to superoxide dismutase (33) and catalase (32,38,39) covalently modified with PUT may enhance the therapeutic usefulness of these antioxidants in treating neurodegenerative diseases (32,33).
Positive_regulation (increases) of permeability associated with neurodegenerative disease
12) Confidence 0.01 Published 2008 Journal AAPS J Section Body Doc Link PMC2761699 Disease Relevance 0.68 Pain Relevance 0
Moreover, there is no indication of increased membrane permeability in the presence of hydrophilic peptides.
Positive_regulation (increased) of permeability
13) Confidence 0.01 Published 2008 Journal AAPS J Section Body Doc Link PMC2761699 Disease Relevance 0 Pain Relevance 0
In comparison, there was a much smaller increase of BBB permeability to doxorubicin conjugated to d-penetratin; this permeability was possibly caused by the opening of the tight junctions.
Positive_regulation (increase) of permeability
14) Confidence 0.01 Published 2008 Journal AAPS J Section Body Doc Link PMC2761699 Disease Relevance 0.05 Pain Relevance 0.06
The possible toxic effects include a generalized increase in vascular permeability and immune complex formation with associated membrane nephropathy.
Positive_regulation (increase) of permeability associated with renal disease
15) Confidence 0.01 Published 2008 Journal AAPS J Section Body Doc Link PMC2761699 Disease Relevance 0.35 Pain Relevance 0
Nevertheless it must be stressed that some authors have suggested that the increased BBB permeability to proteins covalently modified with natural polyamines (PUT, SPD and SPM) may imply mechanisms of transport other than simple electrostatic interaction involving charge density (10).
Positive_regulation (increased) of permeability
16) Confidence 0.01 Published 2008 Journal AAPS J Section Body Doc Link PMC2761699 Disease Relevance 0.23 Pain Relevance 0
In comparison, there was a much smaller increase of BBB permeability to doxorubicin conjugated to d-penetratin; this permeability was possibly caused by the opening of the tight junctions.
Spec (possibly) Positive_regulation (caused) of permeability
17) Confidence 0.01 Published 2008 Journal AAPS J Section Body Doc Link PMC2761699 Disease Relevance 0 Pain Relevance 0.06
This was due at least in part to the presence of an asparagine residue (Asn353) at a position in the second transmembrane domain in place of the aspartate that is completely conserved in all other P2X receptor subunits, because replacement of Asn353 with aspartate increased calcium permeability by ?
Positive_regulation (increased) of permeability
18) Confidence 0.00 Published 2008 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2397467 Disease Relevance 0 Pain Relevance 0
Reversion of the asparagine residue at this position to aspartate (OtP2X[N353D]) significantly increased the calcium permeability of the receptor (by 53%, PCa/PNa = 0.64).
Positive_regulation (increased) of permeability
19) Confidence 0.00 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2397467 Disease Relevance 0 Pain Relevance 0
We found that the substitution of aspartate for this asparagine significantly increased the calcium permeability of OtP2X (Fig. 3).
Positive_regulation (increased) of permeability
20) Confidence 0.00 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2397467 Disease Relevance 0 Pain Relevance 0

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