INT43721

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Context Info
Confidence 0.77
First Reported 1984
Last Reported 2011
Negated 0
Speculated 1
Reported most in Abstract
Documents 49
Total Number 51
Disease Relevance 36.18
Pain Relevance 6.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Vegfa) extracellular space (Vegfa) growth (Vegfa)
extracellular region (Vegfa) cytoplasm (Vegfa)
Anatomy Link Frequency
retina 5
blood 2
GCL 2
endothelial cells 2
neurons 2
Vegfa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
COX2 9 100.00 Very High Very High Very High
cytokine 159 99.80 Very High Very High Very High
Spinal cord 6 99.48 Very High Very High Very High
chemokine 30 99.36 Very High Very High Very High
Somatostatin 12 98.80 Very High Very High Very High
Inflammation 303 98.32 Very High Very High Very High
Snapping jaw 3 98.28 Very High Very High Very High
metalloproteinase 32 98.16 Very High Very High Very High
cINOD 15 97.72 Very High Very High Very High
Osteoarthritis 4 97.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 451 100.00 Very High Very High Very High
Necrosis 37 100.00 Very High Very High Very High
Solid Tumor 15 100.00 Very High Very High Very High
Pituitary Cancer 22 99.86 Very High Very High Very High
Ulcers 150 99.68 Very High Very High Very High
Diabetes Mellitus 729 99.48 Very High Very High Very High
Adhesions 30 99.36 Very High Very High Very High
Glioma 73 99.00 Very High Very High Very High
Canker Sores 3 99.00 Very High Very High Very High
Hypertrophy 13 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High-level expression of vascular endothelial growth factor and its receptors in an aphthous ulcer.
Gene_expression (expression) of vascular endothelial growth factor associated with canker sores
1) Confidence 0.77 Published 2003 Journal J Cutan Med Surg Section Title Doc Link 12574903 Disease Relevance 0.39 Pain Relevance 0.09
Chemotherapy-induced VEGF-A production is possibly mediated by mitogen-activated protein kinase/extracellular regulated kinase pathway, nuclear factor ?
Gene_expression (production) of VEGF-A
2) Confidence 0.75 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886338 Disease Relevance 0.67 Pain Relevance 0.04
Studies in vitro suggest that one mechanism for resistance to chemotherapy is the increased expression of vascular endothelial growth factor A (VEGF-A) that is primarily responsible for the vascularization of solid tumors.37,38 Paclitaxel, docetaxel,39 cisplatin,40 carboplatin,41 anthracyclines,42 fluorouracil43 can induce VEGF-A expression.
Gene_expression (expression) of VEGF-A associated with solid tumor
3) Confidence 0.75 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886338 Disease Relevance 0.63 Pain Relevance 0.04
Studies in vitro suggest that one mechanism for resistance to chemotherapy is the increased expression of vascular endothelial growth factor A (VEGF-A) that is primarily responsible for the vascularization of solid tumors.37,38 Paclitaxel, docetaxel,39 cisplatin,40 carboplatin,41 anthracyclines,42 fluorouracil43 can induce VEGF-A expression.
Gene_expression (expression) of VEGF-A associated with solid tumor
4) Confidence 0.75 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886338 Disease Relevance 0.67 Pain Relevance 0.04
We investigated whether the expression of vascular endothelial growth factor (VEGF) is elevated at the onset of hypertrophy when capillary proliferation is minimal, and whether muscle damage as assessed by muscle force deficits, may occur at the onset of hypertrophy.
Gene_expression (expression) of vascular endothelial growth factor in muscle associated with hypertrophy
5) Confidence 0.70 Published 2003 Journal Jpn. J. Physiol. Section Abstract Doc Link 14529579 Disease Relevance 0.44 Pain Relevance 0.12
VEGF was originally called vascular permeability factor (VPF) and is a potent cause of vascular leakage in the retina, which is hypothesized to enhance angiogenesis by allowing translocation of plasma proteins.
Gene_expression (called) of vascular permeability factor in retina
6) Confidence 0.65 Published 2007 Journal Indian Journal of Ophthalmology Section Body Doc Link PMC2635972 Disease Relevance 0.20 Pain Relevance 0
Sweeny et al showed that VEGF-A protects endothelial cells from the cytotoxicity effect of docetaxel.44 VEGF-A significantly reduces nab-paclitaxel cytotoxicity and the combination of bevacizumab plus nab-paclitaxel abrogates the VEGF-A dependent protective effect on tumor cells.
Gene_expression (protects) of VEGF-A in endothelial cells associated with cancer
7) Confidence 0.65 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886338 Disease Relevance 0.68 Pain Relevance 0.03
VEGF was originally called vascular permeability factor (VPF) and is a potent cause of vascular leakage in the retina, which is hypothesized to enhance angiogenesis by allowing translocation of plasma proteins.
Gene_expression (called) of VPF in retina
8) Confidence 0.65 Published 2007 Journal Indian Journal of Ophthalmology Section Body Doc Link PMC2635972 Disease Relevance 0.20 Pain Relevance 0
Vascular endothelial growth factor (Vegf) was previously shown to be expressed specifically in the condylar cartilage of temporomandibular joint-osteoarthritis (TMJ-OA) model rats.
Gene_expression (expressed) of Vascular endothelial growth factor in temporomandibular joint associated with snapping jaw and osteoarthritis
9) Confidence 0.63 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20171183 Disease Relevance 0.66 Pain Relevance 0.34
In addition, production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and vascular endothelial growth factor (VEGF) production induced by SCF was significantly inhibited by treatment with SC-236.
Gene_expression (production) of vascular endothelial growth factor associated with necrosis and cancer
10) Confidence 0.59 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17320132 Disease Relevance 0.90 Pain Relevance 0.42
Studies in vitro suggest that one mechanism for resistance to chemotherapy is the increased expression of vascular endothelial growth factor A (VEGF-A) that is primarily responsible for the vascularization of solid tumors.37,38 Paclitaxel, docetaxel,39 cisplatin,40 carboplatin,41 anthracyclines,42 fluorouracil43 can induce VEGF-A expression.
Gene_expression (expression) of VEGF-A associated with solid tumor
11) Confidence 0.58 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886338 Disease Relevance 0.71 Pain Relevance 0.04
Local expression of vascular endothelial growth factor (VEGF) was monitored with immunohistochemistry.
Gene_expression (expression) of vascular endothelial growth factor
12) Confidence 0.56 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19191544 Disease Relevance 0.32 Pain Relevance 0
Four weeks after transplantation, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) productions in transplanted sites, current perception threshold, nerve conduction velocity (NCV), sciatic nerve blood flow (SNBF), capillary number–to–muscle fiber ratio in soleus muscles, and sural nerve morphometry were evaluated.
Gene_expression (productions) of vascular endothelial growth factor in blood associated with sciatic nerve
13) Confidence 0.52 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2570407 Disease Relevance 0.54 Pain Relevance 0.24
In addition, production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and vascular endothelial growth factor (VEGF) production induced by SCF was significantly inhibited by treatment with SC-236.
Gene_expression (production) of vascular endothelial growth factor associated with necrosis and cancer
14) Confidence 0.46 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17320132 Disease Relevance 0.87 Pain Relevance 0.41
The number of cells in the retinal ganglion cell layer (GCL), retinal function (using electroretinography [ERG]), and retinal levels of inducible nitric oxide synthase (iNOS), cyclooxygenase2 (COX2), and vascular endothelial growth factor (VEGF) were measured at four months of diabetes.
Gene_expression (levels) of vascular endothelial growth factor in GCL associated with ganglion cysts, diabetes mellitus and cox2
15) Confidence 0.46 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2927372 Disease Relevance 1.63 Pain Relevance 0.28
Studies have also revealed that PDT could cause choroidal hypoperfusion and upregulate the production of vascular endothelial growth factor (VEGF).
Gene_expression (production) of vascular endothelial growth factor
16) Confidence 0.44 Published 2007 Journal Indian Journal of Ophthalmology Section Body Doc Link PMC2635983 Disease Relevance 0.53 Pain Relevance 0
It has known to cause choroidal hypoperfusion and production of vascular endothelial growth factor.
Gene_expression (production) of vascular endothelial growth factor
17) Confidence 0.44 Published 2007 Journal Indian Journal of Ophthalmology Section Abstract Doc Link PMC2635983 Disease Relevance 0.57 Pain Relevance 0
Expression of vascular endothelial growth factor (VEGF) was assessed by real-time RT-PCR and Western blot analysis.
Gene_expression (Expression) of vascular endothelial growth factor
18) Confidence 0.44 Published 2010 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2877244 Disease Relevance 0.52 Pain Relevance 0
The goal of this study was to investigate the effects of SK-MS10 on angiogenic responses such as the microvasculature density, and the expression of vascular endothelial growth factor (VEGF).


Gene_expression (expression) of vascular endothelial growth factor
19) Confidence 0.44 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2877244 Disease Relevance 0.57 Pain Relevance 0.10
Effects of rAAV-angiostatin on expression of vascular endothelial growth factor (VEGF), pigment epithelium-derived factor (PEDF), occludin, and phospho-p42/p44 MAP kinase in retina tissue were analyzed by western blotting.


Spec (analyzed) Gene_expression (expression) of vascular endothelial growth factor in retina
20) Confidence 0.43 Published 2007 Journal Molecular Vision Section Abstract Doc Link PMC2533034 Disease Relevance 0.37 Pain Relevance 0

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