INT43723

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Context Info
Confidence 0.34
First Reported 1984
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 4.96
Pain Relevance 2.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Vegfa) extracellular space (Vegfa) growth (Vegfa)
extracellular region (Vegfa) cytoplasm (Vegfa)
Anatomy Link Frequency
blood 1
paw 1
capillary 1
bone marrow 1
duodenum 1
Vegfa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 22 100.00 Very High Very High Very High
Etanercept 6 99.82 Very High Very High Very High
aspirin 9 99.28 Very High Very High Very High
Serotonin 6 98.76 Very High Very High Very High
Inflammation 13 98.06 Very High Very High Very High
lidocaine 8 86.48 High High
tolerance 1 82.28 Quite High
Pain 2 80.48 Quite High
Restless leg syndrome 1 80.24 Quite High
COX2 1 76.48 Quite High
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 2 99.98 Very High Very High Very High
Adhesions 10 99.36 Very High Very High Very High
Cardiomyopathy 28 99.24 Very High Very High Very High
Uremia 45 98.94 Very High Very High Very High
Diabetic Retinopathy 6 98.16 Very High Very High Very High
INFLAMMATION 16 98.06 Very High Very High Very High
Age-related Macular Degeneration 8 97.88 Very High Very High Very High
Pressure And Volume Under Development 35 97.68 Very High Very High Very High
Glioma 29 97.60 Very High Very High Very High
Cv Unclassified Under Development 10 97.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Notably, aspirin, meloxicam, and etanercept did not change retinal vascular endothelial growth factor levels.
Neg (not) Regulation (change) of vascular endothelial growth factor associated with aspirin and etanercept
1) Confidence 0.34 Published 2002 Journal FASEB J. Section Abstract Doc Link 11821258 Disease Relevance 0.89 Pain Relevance 0.78
The broad aims of the work briefly summarized here were to compare the effects of VEGFA165 and VEGFB167 (500 micro g, i.m., gene transfer) on calf blood pressure ratio and reactive hyperaemia in a chronic rabbit preparation with unilateral limb ischaemia. 3.
Regulation (effects) of VEGFA165 in blood associated with cv unclassified under development and increased venous pressure under development
2) Confidence 0.31 Published 2002 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 12366398 Disease Relevance 0.68 Pain Relevance 0.20
Numerous studies have demonstrated that vascular endothelial growth factor (VEGF) is a key cytokine responsible for the formation of retinal angiogenesis in DR and choroidal neovascularization (CNV) in AMD [2,4-6].
Regulation (responsible) of endothelial growth factor associated with age-related macular degeneration, diabetic retinopathy and cytokine
3) Confidence 0.21 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2862245 Disease Relevance 0.90 Pain Relevance 0.05
Interestingly, activation of Shh signaling caused upregulation of pro-angiogenic growth factors including vascular endothelial growth factor (VEGF) and angiopoietin-1 which resulted in an increased angiogenic response and globally improved the heart function.
Regulation (upregulation) of vascular endothelial growth factor in heart
4) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.29 Pain Relevance 0.04
Changes in the vascular density and, vascular endothelial growth factor, vascular cell adhesion molecule and cytokine levels in the infarcted myocardium after bone marrow cells implantation were examined.


Spec (examined) Regulation (Changes) of vascular endothelial growth factor in bone marrow associated with adhesions and cytokine
5) Confidence 0.12 Published 2008 Journal J Cardiothorac Surg Section Abstract Doc Link PMC2414821 Disease Relevance 0.43 Pain Relevance 0.19
The different changes in interstitial and capillary density in uraemic cardiomyopathy have not yet been explained, but the role of growth factors such as basic fibroblast growth factor (BFGF) and vascular endothelial growth factor (VEGF) has been proposed [44].
Regulation (role) of vascular endothelial growth factor in capillary associated with cardiomyopathy and uremia
6) Confidence 0.11 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024648 Disease Relevance 0.75 Pain Relevance 0.04
Anti-angiogenic treatments of malignant tumors targeting vascular endothelial growth factor receptors (VEGFR) tyrosine kinase are being used in different early stages of clinical trials.
Regulation (targeting) of vascular endothelial growth factor associated with malignant neoplastic disease
7) Confidence 0.09 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2806917 Disease Relevance 0.56 Pain Relevance 0.03
Anti-inflammatory effects of polyamines in serotonin and carrageenan paw edemata - possible mechanism to increase vascular permeability inhibitory protein level which is regulated by glucocorticoids and superoxide radical.
Regulation (regulated) of vascular permeability inhibitory protein in paw associated with inflammation and serotonin
8) Confidence 0.03 Published 1984 Journal Agents Actions Section Title Doc Link 6324559 Disease Relevance 0.41 Pain Relevance 0.41
COX inhibition excites enteric nerves that affect motility, alkaline secretion, and permeability in rat duodenum.
Regulation (affect) of permeability in duodenum
9) Confidence 0.01 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 11668025 Disease Relevance 0 Pain Relevance 0.56
It has been suggested that this difference may be a modulation of the restrictive permeability of the BBB, allowing substances a shortened transport time to cross through the membrane and cytoplasm of the EC and enter the brain parenchyma.
Regulation (modulation) of permeability in parenchyma
10) Confidence 0.00 Published 2008 Journal AAPS J Section Body Doc Link PMC2761699 Disease Relevance 0.05 Pain Relevance 0

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