INT43727

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Context Info
Confidence 0.40
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 4.81
Pain Relevance 7.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP3) extracellular space (MMP3) extracellular region (MMP3)
proteinaceous extracellular matrix (MMP3) nucleus (MMP3) protein complex (MMP3)
Anatomy Link Frequency
synovial cells 4
cartilage 4
synovium 4
macrophage 2
MMP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 177 100.00 Very High Very High Very High
Osteoarthritis 73 99.92 Very High Very High Very High
Infliximab 210 99.82 Very High Very High Very High
Snapping jaw 7 97.68 Very High Very High Very High
Arthritis 22 95.72 Very High Very High Very High
Inflammation 80 93.92 High High
spinal inflammation 226 93.84 High High
Pain 48 93.60 High High
cytokine 30 92.88 High High
Adalimumab 38 91.88 High High
Disease Link Frequency Relevance Heat
Osteoarthritis 71 99.92 Very High Very High Very High
Arthropathy 5 98.24 Very High Very High Very High
Temporomandibular Joint Syndrome 6 97.68 Very High Very High Very High
Arthritis 23 95.72 Very High Very High Very High
Apoptosis 7 95.16 Very High Very High Very High
Low Back Pain 258 93.84 High High
Arthralgia 5 93.84 High High
Multiple Sclerosis 1 91.32 High High
INFLAMMATION 92 90.84 High High
Cancer 77 89.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition by the steroids of synovial collagenase production correlated with inhibition of cartilage collagen breakdown, whereas inhibition of synovial proteoglycanase production did not prevent extensive proteoglycan breakdown.
Negative_regulation (inhibition) of Gene_expression (production) of synovial proteoglycanase in cartilage
1) Confidence 0.40 Published 1984 Journal Biochem. Pharmacol. Section Abstract Doc Link 6324820 Disease Relevance 0.24 Pain Relevance 0.41
Hyaluronate inhibits the interleukin-1beta-induced expression of matrix metalloproteinase (MMP)-1 and MMP-3 in human synovial cells.
Negative_regulation (inhibits) of Gene_expression (expression) of MMP-3 in synovial cells associated with metalloproteinase
2) Confidence 0.38 Published 2004 Journal Tohoku J. Exp. Med. Section Title Doc Link 15383690 Disease Relevance 0.27 Pain Relevance 0.70
These data suggest that HA inhibits the expression and production of MMP-1 and MMP-3 in IL-1beta-stimulated human synovial cells.
Negative_regulation (inhibits) of Gene_expression (expression) of MMP-3 in synovial cells associated with metalloproteinase
3) Confidence 0.38 Published 2004 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 15383690 Disease Relevance 0.19 Pain Relevance 0.88
We therefore prepose that intra-articular HA may rescue inflamed joints from bone and cartilage destruction by reducing the production of MMP-1 and MMP-3.
Negative_regulation (reducing) of Gene_expression (production) of MMP-3 in cartilage associated with metalloproteinase
4) Confidence 0.38 Published 2004 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 15383690 Disease Relevance 0.06 Pain Relevance 0.75
Assessment of MMP-3 concentration
Negative_regulation (Assessment) of Gene_expression (concentration) of MMP-3
5) Confidence 0.37 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575633 Disease Relevance 0.51 Pain Relevance 0.36
A decrease of MMP-3 levels during treatment with TNF-?
Negative_regulation (decrease) of Gene_expression (levels) of MMP-3
6) Confidence 0.37 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592815 Disease Relevance 0.53 Pain Relevance 0.59
Serum levels of MMP-3 were 28.0 ± 28.5 ng/mL before therapy and decreased significantly to 23.5 ± 27.1 ng/mL after 12 weeks and to 19.02 ± 15.83 ng/mL after 36 to 52 weeks of therapy (P = 0.022).
Negative_regulation (decreased) of Gene_expression (levels) of MMP-3
7) Confidence 0.33 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592815 Disease Relevance 0.22 Pain Relevance 0.18
MMP-2, -3, and IL-8 mRNA expression was up-regulated by the compression, and both MMP-1 and -3 protein expression and MMP-2 activity were detected.
Negative_regulation (detected) of Gene_expression (expression) of MMP-1 and -3 protein
8) Confidence 0.32 Published 2007 Journal J. Dent. Res. Section Abstract Doc Link 17652211 Disease Relevance 1.01 Pain Relevance 0.72
Synovial levels of matrix metalloproteinase-3 (MMP-3) and tissue inhibitors of matrix metalloproteinases (TIMP) are also elevated in SpA synovium and treatment with infliximab rapidly downregulates synovial expression of MMP-3 and TIMP and serum MMP-3 (Vandooren et al 2004).
Negative_regulation (downregulates) of Gene_expression (expression) of MMP-3 in synovium associated with infliximab and metalloproteinase
9) Confidence 0.27 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721298 Disease Relevance 0.19 Pain Relevance 0.54
On day 84, there was no significant decrease in biomarker levels in the placebo group, whereas significant reductions in the levels of both MMP-3 and hyaluronan were observed in the 2 sCT groups.
Negative_regulation (reductions) of Gene_expression (levels) of MMP-3
10) Confidence 0.27 Published 2006 Journal Arthritis Rheum. Section Body Doc Link 17009253 Disease Relevance 0.06 Pain Relevance 0
The results demonstrated: (a) that expression levels of the catabolic genes MMP-3 and MMP-13 were suppressed and (b) mRNA expression levels of anabolic genes of collagen II, SOX9 and aggrecan were increased.
Negative_regulation (suppressed) of Gene_expression (expression) of MMP-3
11) Confidence 0.26 Published 2009 Journal Phytochemistry Section Abstract Doc Link 19118849 Disease Relevance 0.28 Pain Relevance 0.34
Pretreatment with 2.5 and 10 mmol/l glucosamine was able, to differing degrees, to downregulate mRNA and protein levels of MMP-1, MMP-3 and MMP-13.
Negative_regulation (downregulate) of Gene_expression (levels) of MMP-3
12) Confidence 0.23 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212570 Disease Relevance 0.31 Pain Relevance 0.12
Here we report a dose-dependent inhibition of macrophage function by way of suppressed supernatant levels of MMP-1, MMP-3, MMP-9, TIMP-1 and TNF-?
Negative_regulation (suppressed) of Gene_expression (levels) of MMP-3 in macrophage
13) Confidence 0.23 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.18 Pain Relevance 0.17
Synovial levels of matrix metalloproteinase-3 (MMP-3) and tissue inhibitors of matrix metalloproteinases (TIMP) are also elevated in SpA synovium and treatment with infliximab rapidly downregulates synovial expression of MMP-3 and TIMP and serum MMP-3 (Vandooren et al 2004).
Negative_regulation (downregulates) of Gene_expression (expression) of MMP-3 in synovium associated with infliximab and metalloproteinase
14) Confidence 0.20 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721298 Disease Relevance 0.19 Pain Relevance 0.54
Suppression of MUC5AC reduced expression of integrins and production of MMP-3 and VEGF
Negative_regulation (reduced) of Gene_expression (production) of MMP-3 associated with metalloproteinase
15) Confidence 0.09 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2893453 Disease Relevance 0.46 Pain Relevance 0.14
We observed a significant 2 log-fold and 4 log-fold decline in MMP-2 and MMP-3 expression levels when the cells were treated with 10 ?
Negative_regulation (decline) of Gene_expression (expression) of MMP-3 associated with metalloproteinase
16) Confidence 0.05 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1559713 Disease Relevance 0.11 Pain Relevance 0.73

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