INT43734

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Context Info
Confidence 0.43
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 14
Disease Relevance 1.42
Pain Relevance 8.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gpr156) signal transducer activity (Gpr156)
Anatomy Link Frequency
pyramidal cells 2
spinal cord 1
muscle 1
mossy fiber 1
ventral 1
Gpr156 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 7 100.00 Very High Very High Very High
Analgesic 2 100.00 Very High Very High Very High
tetrodotoxin 46 99.84 Very High Very High Very High
Opioid 5 99.80 Very High Very High Very High
Hippocampus 8 99.50 Very High Very High Very High
Dopamine 146 99.20 Very High Very High Very High
depression 12 99.08 Very High Very High Very High
Pyramidal cell 13 99.06 Very High Very High Very High
gABA 46 98.92 Very High Very High Very High
Enkephalin 3 98.66 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 12 99.08 Very High Very High Very High
Overactive Bladder 8 98.16 Very High Very High Very High
Pain 4 95.44 Very High Very High Very High
Epilepsy 4 94.76 High High
Bordatella Infection 3 92.08 High High
Urological Neuroanatomy 60 65.92 Quite High
Hypotension 4 41.52 Quite Low
Decapitation 8 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 4 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Surface labelling of recombinant proteins showed a decrease in subunit co-localization and GABAB2 labelling, after capsaicin treatment.
Negative_regulation (decrease) of GABAB2 associated with qutenza
1) Confidence 0.43 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17425567 Disease Relevance 0 Pain Relevance 0.53
GABAB receptor-mediated inhibition of forskolin-stimulated cyclic AMP accumulation in rat spinal cord.
Negative_regulation (inhibition) of GABAB in spinal cord associated with analgesic and spinal cord
2) Confidence 0.41 Published 1993 Journal Neurosci. Lett. Section Title Doc Link 8233093 Disease Relevance 0 Pain Relevance 0.89
Mu opioids enhance mossy fiber synaptic transmission indirectly by reducing GABAB receptor activation.
Negative_regulation (reducing) of GABAB receptor in mossy fiber associated with enkephalin and opioid
3) Confidence 0.33 Published 1999 Journal Brain Res. Section Title Doc Link 10064815 Disease Relevance 0 Pain Relevance 1.15
The GABAB receptor-mediated inhibition of the activity of the mesocorticolimbic neurones might explain the effectiveness of baclofen to suppress nicotine self-administration when microinjected into the VTA [34].
Negative_regulation (inhibition) of GABAB associated with ventral tegmentum and nicotine
4) Confidence 0.26 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526276 Disease Relevance 0 Pain Relevance 1.04
The existence of a tonic GABAB receptor-mediated inhibition of somatodendritic DA release has been suggested by the evidence that, in vivo, the administration of CGP55845A into the ventral tegmental area produces a dose-dependent increase in VTA dopamine levels [49].
Negative_regulation (inhibition) of GABAB in ventral associated with ventral tegmentum and dopamine
5) Confidence 0.23 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526276 Disease Relevance 0 Pain Relevance 0.75
GABAB receptors are present postsynaptically on SPNs and high concentrations of the GABAB agonist, baclofen (10–100??
Negative_regulation (receptors) of GABAB associated with agonist
6) Confidence 0.22 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0.26 Pain Relevance 0.58
In fact evidence suggests that presynaptic GABAB receptors are mainly comprised of GABAB1a/GABAB2 subunits (Billinton et al., 1999; Towers et al., 2000), so pharmacological differences would be unexpected.
Negative_regulation (comprised) of GABAB1a
7) Confidence 0.22 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0 Pain Relevance 0.27
In fact evidence suggests that presynaptic GABAB receptors are mainly comprised of GABAB1a/GABAB2 subunits (Billinton et al., 1999; Towers et al., 2000), so pharmacological differences would be unexpected.
Negative_regulation (comprised) of GABAB2
8) Confidence 0.22 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0 Pain Relevance 0.27
In fact evidence suggests that presynaptic GABAB receptors are mainly comprised of GABAB1a/GABAB2 subunits (Billinton et al., 1999; Towers et al., 2000), so pharmacological differences would be unexpected.
Negative_regulation (comprised) of GABAB
9) Confidence 0.22 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0 Pain Relevance 0.30
GABAB receptor mediated inhibition of field stimulation induced contractions of detrusor muscle strips from newborn rats.
Negative_regulation (inhibition) of GABAB in muscle associated with overactive bladder
10) Confidence 0.21 Published 1984 Journal J Auton Pharmacol Section Title Doc Link 6325464 Disease Relevance 0.48 Pain Relevance 0.30
Ba2+ dramatically reduced postsynaptic GABAB responses; it had no effect on PPD.
Negative_regulation (reduced) of GABAB associated with depression
11) Confidence 0.07 Published 1994 Journal J. Neurophysiol. Section Abstract Doc Link 7884461 Disease Relevance 0.59 Pain Relevance 0.47
In PTX-treated slices the frequency decrease due to GABAB, mu-opioid, and alpha 2-adrenergic receptor activation was attenuated (P < or = 0.05), whereas the SP receptor-mediated response was unaltered.
Negative_regulation (decrease) of GABAB associated with opioid and substance p
12) Confidence 0.04 Published 1996 Journal J. Appl. Physiol. Section Abstract Doc Link 8806921 Disease Relevance 0.09 Pain Relevance 0.61
GABAB receptor-mediated inhibition of tetrodotoxin-resistant GABA release in rodent hippocampal CA1 pyramidal cells.
Negative_regulation (inhibition) of GABAB receptor in pyramidal cells associated with tetrodotoxin, gaba and pyramidal cell
13) Confidence 0.02 Published 1997 Journal J. Neurosci. Section Title Doc Link 8994057 Disease Relevance 0 Pain Relevance 0.98
Tight-seal whole-cell recordings from CA1 pyramidal cells of rodent hippocampus were performed to study GABAB receptor-mediated inhibition of tetrodotoxin (TTX)-resistant IP-SCs.
Negative_regulation (inhibition) of GABAB receptor in pyramidal cells associated with tetrodotoxin, pyramidal cell and hippocampus
14) Confidence 0.02 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 8994057 Disease Relevance 0 Pain Relevance 0.76

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