INT4378

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.47
First Reported 1975
Last Reported 2010
Negated 5
Speculated 0
Reported most in Body
Documents 26
Total Number 27
Disease Relevance 10.20
Pain Relevance 4.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (GH1) extracellular region (GH1)
Anatomy Link Frequency
gonad 4
Blood 2
plasma 2
tibia 2
GH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 29 100.00 Very High Very High Very High
agonist 149 99.90 Very High Very High Very High
Dopamine 136 99.72 Very High Very High Very High
dexamethasone 9 99.14 Very High Very High Very High
rheumatoid arthritis 77 99.08 Very High Very High Very High
Somatostatin 175 98.64 Very High Very High Very High
Fibrositis 14 97.72 Very High Very High Very High
Catecholamine 4 95.60 Very High Very High Very High
Central nervous system 1 92.40 High High
opiate 5 89.60 High High
Disease Link Frequency Relevance Heat
Cancer 227 100.00 Very High Very High Very High
Hypoglycemia 26 100.00 Very High Very High Very High
Growth Problems 200 99.84 Very High Very High Very High
Fracture Healing 1 99.84 Very High Very High Very High
Rheumatoid Arthritis 77 99.08 Very High Very High Very High
Acromegaly 321 98.88 Very High Very High Very High
Disease 226 98.60 Very High Very High Very High
Diabetes Mellitus 34 98.40 Very High Very High Very High
Fibromyalgia 13 97.72 Very High Very High Very High
Sleep Disorders 8 96.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both androgenic and estrogenic hormones markedly increase GH production rates as measured by deconvolution models in the prepubertal human, and compelling data strongly suggest that it is indeed the estrogen which controls the feedback amplification of GH production during puberty even in the male.
Regulation (controls) of Gene_expression (production) of GH
1) Confidence 0.47 Published 1996 Journal Horm. Res. Section Abstract Doc Link 8742123 Disease Relevance 0 Pain Relevance 0.09
It appears that the prepubertal gonad is actively producing sex hormones which might be important in the control of GH production since early childhood.
Regulation (important) of Gene_expression (production) of GH in gonad
2) Confidence 0.47 Published 1996 Journal Horm. Res. Section Abstract Doc Link 8742123 Disease Relevance 0 Pain Relevance 0.08
[Growth hormone (GH) deficiency treatment in children: comparison between uses of pen versus bottles/syringes on GH administration].
Regulation (bottles/syringes) of Gene_expression (administration) of GH
3) Confidence 0.45 Published 2007 Journal Arq Bras Endocrinol Metabol Section Title Doc Link 18157384 Disease Relevance 0.07 Pain Relevance 0.07
Dexamethasone administration to normal subjects did not alter GH levels in the first 2 h of the test.
Neg (not) Regulation (alter) of Gene_expression (levels) of GH associated with dexamethasone
4) Confidence 0.44 Published 1993 Journal Neuroendocrinology Section Abstract Doc Link 8284031 Disease Relevance 0.16 Pain Relevance 0.32
While these data do not exclude the possibility of a short loop feedback control of GH secretion, they strongly suggest that the direction of the GH response to a provocative stimulus is determined by the antecedent GH level and that an alpha-adrenoreceptor mechanism is involved in such a biphasic modulation of GH levels.
Regulation (modulation) of Gene_expression (levels) of GH
5) Confidence 0.44 Published 1985 Journal Metab. Clin. Exp. Section Abstract Doc Link 3982277 Disease Relevance 0.06 Pain Relevance 0.74
GH release in children after dexamethasone administration followed the pattern previously described for adults, i.e. there were no modifications of basal GH levels in the first 2 h, the GH peak appeared around the third hour, and the GH levels remained increased until the fourth hour after dexamethasone administration.
Neg (no) Regulation (modifications) of Gene_expression (levels) of GH associated with dexamethasone
6) Confidence 0.44 Published 1992 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1639956 Disease Relevance 0.13 Pain Relevance 0.31
As a first step to standardizing GH measurement", they "recommend the reporting of GH concentrations in ?
Regulation (reporting) of Gene_expression (concentrations) of GH
7) Confidence 0.36 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2459162 Disease Relevance 0.14 Pain Relevance 0
The management of her diabetes was also more effective (with fewer episodes of severe hypoglycaemia) when her GH and IGF-1 levels were controlled.
Regulation (controlled) of Gene_expression (levels) of GH associated with hypoglycemia and diabetes mellitus
8) Confidence 0.35 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2845144 Disease Relevance 0.77 Pain Relevance 0.09
1.2 SD over the course of 7 years.26 Factors that tend to predict a positive response to GH treatment include GH dose, degree of height deficit compared to parentsÂ’ heights, young age, and first year height velocity.1,34

Safety of GH treatment in ISS

Regulation (include) of Gene_expression (dose) of GH associated with growth problems
9) Confidence 0.33 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2898102 Disease Relevance 0.56 Pain Relevance 0
Efficacy of GH treatment in ISS
Regulation (Efficacy) of Gene_expression (treatment) of GH associated with growth problems
10) Confidence 0.33 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2898102 Disease Relevance 0.84 Pain Relevance 0
On the contrary, GH administration had no measurable effects on fracture healing in a standardized tibia osteotomy rabbit model (20).
Regulation (effects) of Gene_expression (administration) of GH in tibia associated with fracture healing
11) Confidence 0.30 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2858840 Disease Relevance 0.25 Pain Relevance 0
Basal levels were similar but there was no rise in GH levels in the AF patients.
Neg (no) Regulation (rise) of Gene_expression (levels) of GH
12) Confidence 0.23 Published 1984 Journal Clin Exp Hypertens A Section Abstract Doc Link 6398141 Disease Relevance 0.10 Pain Relevance 0.29
It appears that the prepubertal gonad is actively producing sex hormones which might be important in the control of GH production since early childhood.
Regulation (control) of Gene_expression (production) of GH in gonad
13) Confidence 0.21 Published 1996 Journal Horm. Res. Section Abstract Doc Link 8742123 Disease Relevance 0 Pain Relevance 0.08
It is suggested that ectopic production of HGH by the tumour in this case was not responsible for the changes of hypertrophic osterarthropathy.
Neg (not) Regulation (responsible) of Gene_expression (production) of HGH associated with cancer
14) Confidence 0.18 Published 1975 Journal Age Ageing Section Abstract Doc Link 1146670 Disease Relevance 0.87 Pain Relevance 0.09
Although the hGH concentrations
Regulation (Although) of Gene_expression (concentrations) of hGH
15) Confidence 0.15 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551587 Disease Relevance 0 Pain Relevance 0.09
13] have reported GH serum levels as low as 0.015,
Regulation (reported) of Gene_expression (levels) of GH
16) Confidence 0.15 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551587 Disease Relevance 0.19 Pain Relevance 0
The increase in GH concentration was considered insufficient, when the peak GH concentration was below 3 ?
Regulation (peak) of Gene_expression (concentration) of GH
17) Confidence 0.14 Published 2009 Journal Pituitary Section Body Doc Link PMC2764055 Disease Relevance 0.37 Pain Relevance 0.10
The pattern of reduced circulating IGF-I and IGFBP-3 with an unchanged GH total production rate in patients with RA, as observed in our study, appears to be consistent with GH resistance or insensitivity [20,25].
Neg (unchanged) Regulation (unchanged) of Gene_expression (production) of GH associated with rheumatoid arthritis
18) Confidence 0.12 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206381 Disease Relevance 1.09 Pain Relevance 0.30
To gain further insight into the mechanisms leading to dysregulation of the GH-IGF-1 axis in these patients, we assessed 24-h spontaneous GH secretion, GH responses to GHRH, and IGF-1 and IGF binding protein (BP)-3 levels before and after 4 days treatment with human (h)GH.
Regulation (dysregulation) of Gene_expression (axis) of GH
19) Confidence 0.09 Published 1999 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 10487713 Disease Relevance 1.12 Pain Relevance 0.51
First-line therapy with somatostatin analogues in patients with previously untreated acromegaly has received considerable attention since Newman et al showed that primary therapy with subcutaneous octreotide was as effective as adjuvant therapy with subcutaneous octreotide (following surgery or radiotherapy) at controlling GH and IGF-1 levels in patients with large or invasive tumors without visual or neurological disturbances [98].
Regulation (controlling) of Gene_expression (levels) of GH associated with acromegaly, cancer and somatostatin
20) Confidence 0.08 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2887860 Disease Relevance 0.44 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox