INT438

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Context Info
Confidence 0.78
First Reported 1978
Last Reported 2010
Negated 6
Speculated 13
Reported most in Abstract
Documents 376
Total Number 389
Disease Relevance 159.11
Pain Relevance 169.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
PVN 37
neurons 33
hypothalamus 27
amygdala 18
brain 16
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 711 100.00 Very High Very High Very High
antagonist 547 100.00 Very High Very High Very High
Opioid 435 100.00 Very High Very High Very High
Enkephalin 365 100.00 Very High Very High Very High
Neuropeptide 234 100.00 Very High Very High Very High
Fibrositis 195 100.00 Very High Very High Very High
Visceral pain 181 100.00 Very High Very High Very High
Nerve growth factor 127 100.00 Very High Very High Very High
substance P 124 100.00 Very High Very High Very High
antidepressant 101 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 1685 100.00 Very High Very High Very High
Chronic Renal Failure 1366 100.00 Very High Very High Very High
Cancer 332 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

181 100.00 Very High Very High Very High
Sleep Disorders 131 100.00 Very High Very High Very High
Hypoglycemia 44 100.00 Very High Very High Very High
Necrosis 30 100.00 Very High Very High Very High
Shock 250 99.92 Very High Very High Very High
Urological Neuroanatomy 243 99.92 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

1227 99.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We propose a specific role for down-regulation of opiate receptor signaling in increased expression of the CRH gene in the amygdala.
Gene_expression (expression) of CRH gene in amygdala associated with opiate and amygdala
1) Confidence 0.78 Published 2002 Journal Neuroscience Section Abstract Doc Link 12074902 Disease Relevance 0.23 Pain Relevance 1.36
Our findings of an increase in amygdalar CRH gene expression during early cocaine withdrawal support a potentially important role for amygdalar CRH activity in the anxiogenic and aversive consequences of withdrawal from cocaine during a time when humans are most subject to relapse.
Gene_expression (expression) of CRH associated with withdrawal, recurrence and cocaine
2) Confidence 0.78 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12782395 Disease Relevance 0.30 Pain Relevance 1.04
On the other hand, in rats chronically treated with morphine, the intensity of labelling for CRF mRNA was significantly reduced, suggesting a decrease in the synthesis of CRF.
Gene_expression (synthesis) of CRF associated with morphine
3) Confidence 0.78 Published 2003 Journal J. Neuroendocrinol. Section Abstract Doc Link 12716409 Disease Relevance 0 Pain Relevance 0.90
In conclusion, present results show that, in addition to modifications in corticosterone secretion and in noradrenaline turnover, chronic morphine administration produces a reduction in the synthesis of CRF and AVP.
Gene_expression (synthesis) of CRF associated with noradrenaline and morphine
4) Confidence 0.78 Published 2003 Journal J. Neuroendocrinol. Section Abstract Doc Link 12716409 Disease Relevance 0 Pain Relevance 0.69
The data provide the first demonstration of a central stimulatory effect of adrenaline on the secretory activity of CRH41 producing neurons, in unanesthetized, free-moving rats.
Gene_expression (producing) of CRH41 in neurons
5) Confidence 0.78 Published 1987 Journal C. R. Acad. Sci. III, Sci. Vie Section Abstract Doc Link 3124934 Disease Relevance 0 Pain Relevance 0.08
Corticotropin-releasing hormone (CRH) produces analgesia in a thermal injury model independent of its effect on systemic beta-endorphin and corticosterone.
Gene_expression (produces) of CRH associated with injury and analgesia
6) Confidence 0.78 Published 2004 Journal Regul. Pept. Section Title Doc Link 14759555 Disease Relevance 0.44 Pain Relevance 0.56
Corticotropin-releasing hormone (CRH) produces analgesia in a thermal injury model independent of its effect on systemic beta-endorphin and corticosterone.
Gene_expression (produces) of Corticotropin-releasing hormone associated with injury and analgesia
7) Confidence 0.78 Published 2004 Journal Regul. Pept. Section Title Doc Link 14759555 Disease Relevance 0.44 Pain Relevance 0.56
To assess whether glucocorticoids exert their inhibitory effect on CRH expression directly on parvocellular neurones or indirectly through a complex neuronal circuit, we examined the effect of corticosterone (CORT) and dexamethasone (DEX) on CRH mRNA levels in slice explant cultures of the rat hypothalamus.
Gene_expression (expression) of CRH in hypothalamus associated with dexamethasone
8) Confidence 0.78 Published 2008 Journal J. Neuroendocrinol. Section Abstract Doc Link 18624927 Disease Relevance 0.09 Pain Relevance 0.22
Type II corticosteroid receptor agonists act directly on paraventricular neurones to inhibit basal and forskolin-induced CRH mRNA expression in explant cultures of the rat hypothalamus.
Gene_expression (expression) of CRH mRNA in hypothalamus associated with corticosteroid and agonist
9) Confidence 0.78 Published 2008 Journal J. Neuroendocrinol. Section Abstract Doc Link 18624927 Disease Relevance 0 Pain Relevance 0.48
CORT (500 nm) or DEX (50 nm) treatment for 24 h significantly inhibited CRH expression in the parvocellular neurones and this effect of corticosteroids was not affected following blockade of voltage dependent sodium channels by TTX.
Gene_expression (expression) of CRH associated with corticosteroid, sodium channel and dexamethasone
10) Confidence 0.78 Published 2008 Journal J. Neuroendocrinol. Section Abstract Doc Link 18624927 Disease Relevance 0.06 Pain Relevance 0.54
Under basal conditions, CRH mRNA expressing cells were exclusively revealed in the paraventricular region along the third ventricle.
Gene_expression (expressing) of CRH mRNA in third ventricle
11) Confidence 0.78 Published 2008 Journal J. Neuroendocrinol. Section Abstract Doc Link 18624927 Disease Relevance 0.08 Pain Relevance 0.40
CRH mRNA expression was measured by in situ hybridisation histochemistry.
Gene_expression (expression) of CRH mRNA
12) Confidence 0.78 Published 2008 Journal J. Neuroendocrinol. Section Abstract Doc Link 18624927 Disease Relevance 0.08 Pain Relevance 0.35
Peripheral but not intracerebroventricular corticotropin-releasing hormone (CRH) produces antinociception which is not opioid mediated.
Gene_expression (produces) of corticotropin-releasing hormone associated with antinociception, analgesic, opioid and intracerebroventricular
13) Confidence 0.78 Published 1989 Journal Brain Res. Section Title Doc Link 2605516 Disease Relevance 0.33 Pain Relevance 1.38
Corticotropin-releasing factor (CRF) produces analgesia in humans and rats.
Gene_expression (produces) of Corticotropin-releasing factor associated with pain and analgesia
14) Confidence 0.78 Published 1987 Journal Brain Res. Section Title Doc Link 3315118 Disease Relevance 0.09 Pain Relevance 0.64
Corticotropin-releasing factor (CRF) produces analgesia in humans and rats.
Gene_expression (produces) of CRF associated with pain and analgesia
15) Confidence 0.78 Published 1987 Journal Brain Res. Section Title Doc Link 3315118 Disease Relevance 0.09 Pain Relevance 0.64
In painful inflammation, exogenous as well as endogenous corticotropin-releasing hormone (CRH) can release opioid peptides (mainly beta-endorphin) from various types of immune cells and produce antinociception by activating opioid receptors on peripheral sensory nerve endings.
Gene_expression (produce) of CRH in sensory nerve associated with antinociception, pain, inflammation, opioid receptor and opioid
16) Confidence 0.78 Published 2003 Journal Pain Section Abstract Doc Link 14659512 Disease Relevance 0.23 Pain Relevance 0.67
In painful inflammation, exogenous as well as endogenous corticotropin-releasing hormone (CRH) can release opioid peptides (mainly beta-endorphin) from various types of immune cells and produce antinociception by activating opioid receptors on peripheral sensory nerve endings.
Gene_expression (produce) of endogenous corticotropin-releasing hormone in sensory nerve associated with antinociception, pain, inflammation, opioid receptor and opioid
17) Confidence 0.78 Published 2003 Journal Pain Section Abstract Doc Link 14659512 Disease Relevance 0.24 Pain Relevance 0.67
Immunofluorescence techniques combined with laser scanning confocal microscopy (LSCM) were used to investigate VIP and CRF expression in the duodenum.
Spec (investigate) Gene_expression (expression) of CRF in duodenum
18) Confidence 0.77 Published 2007 Journal World J. Gastroenterol. Section Body Doc Link 18023100 Disease Relevance 0.15 Pain Relevance 0
Compared to the control group, FITC fluorescence of duodenal CRF expression and plasma CRF levels in the depressed rats increased significantly (fluorescence intensity of duodenal CRF: 11.82 +/- 2.54 vs 25.17 +/- 4.63; plasma CRF: 11.82 +/- 2.54 ng/L vs 25.17 +/- 4.63 ng/L, P < 0.01), whereas duodenal VIP expression and plasma VIP levels decreased significantly (fluorescence intensity of duodenal VIP: 67.37 +/- 18.90 vs 44.51 +/- 16.37; plasma VIP: 67.37 +/- 18.90 ng/L vs 44.51 +/- 16.37 ng/L, P < 0.01).
Gene_expression (expression) of CRF in plasma
19) Confidence 0.77 Published 2007 Journal World J. Gastroenterol. Section Body Doc Link 18023100 Disease Relevance 0.13 Pain Relevance 0
Effect of fluoxetine on depression-induced changes in the expression of vasoactive intestinal polypeptide and corticotrophin releasing factor in rat duodenum.
Gene_expression (expression) of corticotrophin releasing factor in duodenum associated with depression and fluoxetine
20) Confidence 0.77 Published 2007 Journal World J. Gastroenterol. Section Title Doc Link 18023100 Disease Relevance 0.10 Pain Relevance 0.38

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