INT43811

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 1983
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 2.52
Pain Relevance 8.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Tyr) cell proliferation (Tyr) oxidoreductase activity (Tyr)
cellular_component (Tyr) cytoplasm (Tyr)
Anatomy Link Frequency
dorsal horn 2
projection neurons 1
Tyr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 14 100.00 Very High Very High Very High
Dorsal horn 4 100.00 Very High Very High Very High
Inflammation 22 99.88 Very High Very High Very High
Clonidine 7 99.68 Very High Very High Very High
Opioid 9 99.52 Very High Very High Very High
Morphine 2 99.44 Very High Very High Very High
agonist 11 99.42 Very High Very High Very High
Dopamine 57 99.28 Very High Very High Very High
Glutamate receptor 9 98.48 Very High Very High Very High
opioid receptor 5 98.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 16 99.88 Very High Very High Very High
Urological Neuroanatomy 2 98.48 Very High Very High Very High
Neuroblastoma 4 98.02 Very High Very High Very High
Hypotension 3 97.24 Very High Very High Very High
Hyperalgesia 8 96.88 Very High Very High Very High
Anxiety Disorder 9 93.84 High High
Shock 2 76.40 Quite High
Stress 10 55.96 Quite High
Apoptosis 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we show that in rats with Freund's adjuvant-induced inflammation, the increased dorsal horn NR2B tyr-P is blocked by group I metabotropic glutamate receptor (mGluR) antagonists [7-(hydroxyimino)cyclopropa[b] chromen-1a-carboxylate ethyl ester (CPCCOEt) and 2-methyl-6-(phenylethynyl)-pyridine (MPEP), by the Src inhibitor CGP 77675, but not by the MAP kinase inhibitor 2'-amino-3'-methoxyflavone.
Positive_regulation (increased) of tyr in dorsal horn associated with inflammation, antagonist, glutamate receptor and dorsal horn
1) Confidence 0.45 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15483135 Disease Relevance 0.44 Pain Relevance 0.85
In a dorsal horn slice preparation, the group I (dihydroxyphenylglycine), but not group II [(2R,4R)-4-aminopyrrolidine-2,3-dicarboxylate] and III [L-AP 4 (L-(+)-2-amino-4-phosphonobutyric acid)], mGluR agonists, an IP3 receptor (D-IP3) agonist, and a PKC (PMA) activator, induces NR2B tyr-P similar to that seen in vivo after inflammation.
Positive_regulation (induces) of tyr in dorsal horn associated with inflammation, agonist and dorsal horn
2) Confidence 0.45 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15483135 Disease Relevance 0.61 Pain Relevance 1.13
High performance liquid chromatography separation and electrochemical detection were used to quantify accumulation of the primary N-terminal products of enkephalin hydrolysis, Tyr and Tyr-Gly-Gly.
Positive_regulation (accumulation) of Tyr associated with enkephalin
3) Confidence 0.38 Published 1993 Journal Peptides Section Abstract Doc Link 8483796 Disease Relevance 0.08 Pain Relevance 0.36
High performance liquid chromatography separation and electrochemical detection were used to quantify accumulation of the primary N-terminal products of enkephalin hydrolysis, Tyr and Tyr-Gly-Gly.
Positive_regulation (accumulation) of Tyr associated with enkephalin
4) Confidence 0.38 Published 1993 Journal Peptides Section Abstract Doc Link 8483796 Disease Relevance 0.08 Pain Relevance 0.36
Morphine and NSD 1015 were found to increase Tyr levels. gamma-Butyrolactone, haloperidol, and haloperidol combined with amfonelic acid decreased the Tyr content in a manner related to their stimulatory effect on DA biosynthesis.
Positive_regulation (increase) of Tyr associated with dopamine and morphine
5) Confidence 0.38 Published 1983 Journal J. Neurochem. Section Abstract Doc Link 6827272 Disease Relevance 0.19 Pain Relevance 0.48
Contrary to opioid peptides which strikly require Tyr in position 1, the active core that activates the OP4 appears to be towards the centre of the peptide molecule and includes Phe4.
Positive_regulation (require) of Tyr associated with opioid
6) Confidence 0.13 Published 1999 Journal Farmaco Section Abstract Doc Link 10668183 Disease Relevance 0 Pain Relevance 1.14
Substitution of the Phe3 aromatic ring in H-Tyr-Ticpsi[CH2-NH]Phe-Phe-OH with cyclohexylalanine (Cha) has been reported to result in a compound, H-Tyr-Ticpsi[CH2-NH]Cha-Phe-OH (TICP[psi]), showing substantially increased delta-opioid antagonist potency and high delta selectivity.
Positive_regulation (result) of H-Tyr-Ticpsi associated with antagonist, opioid and potency
7) Confidence 0.11 Published 1999 Journal Peptides Section Abstract Doc Link 10499425 Disease Relevance 0 Pain Relevance 0.33
Structure-activity relationship studies have shown that the N-terminal tripeptide, Tyr-D-Xaa-Phe (where Xaa is either Ala or Met), is necessary for binding with both the mu- and delta-receptors while the nature and/or the conformation of the C-terminus His-Leu-Met-Asp-NH2 of dermenkephalin are responsible for addressing the peptide to the delta-receptor.
Positive_regulation (necessary) of Tyr
8) Confidence 0.10 Published 1996 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 8791158 Disease Relevance 0 Pain Relevance 0.21
In a crude membrane preparation of the neuroblastoma cells the level of Tyr is reduced to 13% and that of Tyr-Gly to 10% of the initial value, whereas Tyr-Gly-Gly is increased to about 5 times the initial value.
Positive_regulation (increased) of Tyr-Gly associated with neuroblastoma
9) Confidence 0.10 Published 1984 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6328331 Disease Relevance 0.33 Pain Relevance 0.32
The proportion of DOPAC and DA decreased, whereas that of OCT and TYR significantly increased (Fig 7b).
Positive_regulation (increased) of TYR associated with dopamine
10) Confidence 0.05 Published 2008 Journal Journal of Neurochemistry Section Body Doc Link PMC2324205 Disease Relevance 0.06 Pain Relevance 0.44
Clonidine attenuated the increases in c-fos in the mNTS and cRVLM and c-jun gene expression in the mNTS and rRVLM caused by NP-evoked hypotension and also reduced the basal expression of c-jun mRNA in the mNTS and rRVLM.
Positive_regulation (increases) of cRVLM associated with hypotension and clonidine
11) Confidence 0.01 Published 2000 Journal Brain Res. Section Abstract Doc Link 10677633 Disease Relevance 0.18 Pain Relevance 0.71
We hypothesize that cPSPs are generated by positive feedback between a subset of interneurons and a subset of glutamatergic projection neurons.
Positive_regulation (generated) of cPSPs in projection neurons associated with projection neuron
12) Confidence 0.01 Published 2009 Journal Neuroscience Section Abstract Doc Link 19786076 Disease Relevance 0.19 Pain Relevance 0.84
We have now further characterized these cPSPs by inducing cPSPs routinely in 5 mM extracellular K(+).
Positive_regulation (inducing) of cPSPs
13) Confidence 0.01 Published 2009 Journal Neuroscience Section Abstract Doc Link 19786076 Disease Relevance 0.17 Pain Relevance 0.77
Mefloquine facilitated cPSPs within 10 min of application.
Positive_regulation (facilitated) of cPSPs
14) Confidence 0.01 Published 2009 Journal Neuroscience Section Abstract Doc Link 19786076 Disease Relevance 0.20 Pain Relevance 0.91

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox