INT439

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Context Info
Confidence 0.81
First Reported 1974
Last Reported 2011
Negated 5
Speculated 7
Reported most in Abstract
Documents 976
Total Number 984
Disease Relevance 100.96
Pain Relevance 363.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gnrh1) extracellular region (Gnrh1) molecular_function (Gnrh1)
Anatomy Link Frequency
pituitary 63
neurons 58
hypothalamus 56
median eminence 35
gonadal 22
Gnrh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 2044 100.00 Very High Very High Very High
agonist 929 100.00 Very High Very High Very High
Opioid 807 100.00 Very High Very High Very High
Dopamine 775 100.00 Very High Very High Very High
substance P 409 100.00 Very High Very High Very High
Neuropeptide 384 100.00 Very High Very High Very High
Neurotransmitter 378 100.00 Very High Very High Very High
Enkephalin 320 100.00 Very High Very High Very High
Calcitonin gene-related peptide 309 100.00 Very High Very High Very High
Somatostatin 220 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 250 100.00 Very High Very High Very High
Alzheimer's Dementia 546 99.84 Very High Very High Very High
Chronic Renal Failure 8 99.80 Very High Very High Very High
Hypoglycemia 28 99.78 Very High Very High Very High
Galactorrhea 182 99.76 Very High Very High Very High
Aging 78 99.72 Very High Very High Very High
Stress 1331 99.68 Very High Very High Very High
Endometriosis (extended) 148 99.68 Very High Very High Very High
Natriuresis 131 99.66 Very High Very High Very High
Cancer 491 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The amount of LHRH released into hypophysial portal blood during consecutive 30-min periods was determined by radioimmunoassay.
Localization (released) of LHRH in blood
1) Confidence 0.81 Published 1999 Journal J. Neuroendocrinol. Section Abstract Doc Link 9918230 Disease Relevance 0 Pain Relevance 0.35
Abundant evidence suggests that opiatergic neurons play an important intermediary role in the regulation of LHRH release by ovarian steroids; however, it is unclear whether opiates communicate directly or indirectly with LHRH neurons.
Localization (release) of LHRH in neurons associated with opiate
2) Confidence 0.81 Published 1997 Journal Endocrinology Section Abstract Doc Link 9075729 Disease Relevance 0 Pain Relevance 0.25
With advancing age, subtle and progressive disintegration of several components of peptidergic signals that drive luteinizing-hormone-releasing hormone (LHRH) secretion contribute to diminished pituitary-gonadal function in both sexes of the rat.
Localization (secretion) of drive luteinizing-hormone-releasing hormone in pituitary
3) Confidence 0.81 Published 1993 Journal J. Reprod. Fertil. Suppl. Section Abstract Doc Link 8315613 Disease Relevance 0.25 Pain Relevance 0.13
Supernatants from the incubate were used to coincubate pituitaries in order to study the effect on luteinizing hormone release.
Localization (release) of luteinizing hormone
4) Confidence 0.81 Published 1982 Journal Neuroendocrinology Section Abstract Doc Link 7043300 Disease Relevance 0.08 Pain Relevance 0.65
It is concluded that M blocks the DA-mediated release of gonadotropin-releasing hormone in the rat hypothalamus.
Localization (release) of gonadotropin-releasing hormone in hypothalamus associated with dopamine
5) Confidence 0.81 Published 1982 Journal Neuroendocrinology Section Abstract Doc Link 7043300 Disease Relevance 0.09 Pain Relevance 0.50
Sections from the diagonal band of Broca and the preoptic area of adult male and diestrus II female rats were immunocytochemically processed for dual localization of GnRH and BE.
Localization (localization) of GnRH in preoptic area
6) Confidence 0.81 Published 1990 Journal Endocrinology Section Abstract Doc Link 2137080 Disease Relevance 0 Pain Relevance 0.14
Pubertal and young adult male rats release more luteinizing hormone (LH) in response to luteinizing hormone releasing hormone (LHRH) if pretreated with LHRH than if pretreated with saline.
Localization (release) of luteinizing hormone
7) Confidence 0.81 Published 1985 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 3889929 Disease Relevance 0 Pain Relevance 0.10
Evidence from our laboratory suggests that the hypothalamic impairment compromises regulation of the endogenous opioid system engendering a persistent opiatergic suppression of gonadotropin-releasing hormone secretion, which is subsequently reflected in a chronically low pituitary content of gonadotropin-releasing hormone receptors.
Localization (secretion) of gonadotropin-releasing hormone in pituitary associated with endogenous opioid
8) Confidence 0.81 Published 1989 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 2557144 Disease Relevance 0.17 Pain Relevance 0.10
The purpose of this study was (1) to characterize more fully the effects of phorbol esters to stimulate GnRH release in vitro and (2) to determine whether cocaine (which disrupts estrous cyclicity in rats) affected phorbol ester stimulation of GnRH release in vitro.
Localization (release) of GnRH associated with cocaine
9) Confidence 0.81 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1475011 Disease Relevance 0 Pain Relevance 0.09
Perfusion results showed that 10-min pulses of phorbol 12-myristate 13-acetate or phorbol 12,13-dibutyrate (PDBu) increased GnRH release in dose-dependent fashion (10(-10) to 10(-6) M) but had no effect on aminergic transmitter release.
Localization (release) of GnRH
10) Confidence 0.81 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1475011 Disease Relevance 0 Pain Relevance 0.37
These results suggest a role for protein kinase C in regulating the release of GnRH.
Localization (release) of GnRH associated with kinase c
11) Confidence 0.81 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1475011 Disease Relevance 0 Pain Relevance 0.45
PDBu-stimulated GnRH release was blocked by both tetrodotoxin and cocaine, known inhibitors of Na+ influx.
Localization (release) of GnRH associated with tetrodotoxin and cocaine
12) Confidence 0.81 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1475011 Disease Relevance 0 Pain Relevance 0.43
Phorbol esters stimulate in vitro GnRH release from the hypothalamus of the estrogen-primed, ovariectomized rat: inhibitory effects of cocaine.
Localization (release) of GnRH in hypothalamus associated with cocaine
13) Confidence 0.81 Published 1992 Journal Neuroendocrinology Section Title Doc Link 1475011 Disease Relevance 0 Pain Relevance 0.20
The purpose of this study was (1) to characterize more fully the effects of phorbol esters to stimulate GnRH release in vitro and (2) to determine whether cocaine (which disrupts estrous cyclicity in rats) affected phorbol ester stimulation of GnRH release in vitro.
Localization (release) of GnRH associated with cocaine
14) Confidence 0.81 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1475011 Disease Relevance 0 Pain Relevance 0.09
Because release of gonadotropin-releasing hormone into hypophysial portal blood can be observed under Althesin but is suppressed or blocked by chloralose-urethane, urethane, and pentobarbital, Althesin is the anesthetic of choice in studies concerned with the neural control of ovulatory hormone release.
Localization (release) of gonadotropin-releasing hormone in neural
15) Confidence 0.81 Published 1984 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 6744108 Disease Relevance 0 Pain Relevance 0.11
In vivo secretion of LHRH in ovariectomized rats is regulated by a possible autofeedback mechanism.
Localization (secretion) of LHRH
16) Confidence 0.80 Published 1987 Journal Neuroendocrinology Section Title Doc Link 3302744 Disease Relevance 0 Pain Relevance 0.21
An episodic secretion of LHRH in pituitary portal blood was observed in ovariectomized and hypophysectomized rats under Saffan anesthesia.
Localization (secretion) of LHRH in blood associated with anesthesia
17) Confidence 0.80 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 3302744 Disease Relevance 0 Pain Relevance 0.20
This inhibitory action of the LHRH agonist on LHRH release was blocked by an LHRH antagonist.
Localization (release) of LHRH associated with antagonist and agonist
18) Confidence 0.80 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 3302744 Disease Relevance 0 Pain Relevance 0.23
Because neural control of gonadotropins is mediated through luteinizing hormone releasing hormone (LHRH) secreting neurons, we examined the postulated changes in the opioid control of gonadotropins more directly by studying isolated hypothalamic fragments in vitro.
Localization (releasing) of luteinizing hormone in neurons associated with opioid
19) Confidence 0.80 Published 1998 Journal J. Gerontol. A Biol. Sci. Med. Sci. Section Abstract Doc Link 9597043 Disease Relevance 0.10 Pain Relevance 0.30
Because neural control of gonadotropins is mediated through luteinizing hormone releasing hormone (LHRH) secreting neurons, we examined the postulated changes in the opioid control of gonadotropins more directly by studying isolated hypothalamic fragments in vitro.
Localization (secreting) of LHRH in neurons associated with opioid
20) Confidence 0.80 Published 1998 Journal J. Gerontol. A Biol. Sci. Med. Sci. Section Abstract Doc Link 9597043 Disease Relevance 0.10 Pain Relevance 0.33

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