INT43901

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Context Info
Confidence 0.37
First Reported 1984
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 65
Total Number 66
Disease Relevance 56.32
Pain Relevance 7.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Ptpn2) endoplasmic reticulum (Ptpn2) nucleus (Ptpn2)
cytoplasm (Ptpn2)
Anatomy Link Frequency
heart 6
dopaminergic neurons 5
neuronal 5
neurons 5
pore 4
Ptpn2 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 1254 99.84 Very High Very High Very High
Morphine 34 99.84 Very High Very High Very High
gABA 85 99.48 Very High Very High Very High
Substantia nigra 112 99.08 Very High Very High Very High
Dopamine 393 98.00 Very High Very High Very High
addiction 47 97.88 Very High Very High Very High
Eae 100 90.92 High High
COX-2 inhibitor 152 88.88 High High
Opioid 34 88.40 High High
monoamine 40 87.84 High High
Disease Link Frequency Relevance Heat
Parkinson's Disease 5812 100.00 Very High Very High Very High
Poisoning 24 100.00 Very High Very High Very High
Drug Induced Neurotoxicity 163 99.64 Very High Very High Very High
Toxicity 147 99.64 Very High Very High Very High
Reperfusion Injury 1013 99.62 Very High Very High Very High
Death 335 99.36 Very High Very High Very High
Injury 293 99.32 Very High Very High Very High
Cv Unclassified Under Development 2293 99.28 Very High Very High Very High
Targeted Disruption 487 98.72 Very High Very High Very High
Stress 730 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
H2/Mg water showed a similar protective effect as H2-bubbled water on the loss of dopaminergic neurons in acute MPTP model mice.
Negative_regulation (loss) of MPTP in dopaminergic neurons associated with parkinson's disease
1) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.81 Pain Relevance 0
Therefore, the effect of H2 water against the loss of dopaminergic neurons in SNpc by MPTP was not related to the metabolism of MPTP.


Negative_regulation (metabolism) of MPTP in dopaminergic neurons associated with parkinson's disease
2) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 1.34 Pain Relevance 0
Our present study demonstrates that MPTP significantly reduces total distance traveled and vertical activity of the mice, and that valdecoxib decreases MPTP-induced behavioral impairments.
Negative_regulation (decreases) of MPTP associated with parkinson's disease
3) Confidence 0.35 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1440849 Disease Relevance 0.75 Pain Relevance 0.07
Pyruvate has three beneficial effects that may contribute towards its inhibition of MPTP opening: it is a free radical scavenger, it maintains a lower intracellular pH during the early phase of reperfusion and it is an excellent fuel for ATP synthesis that bypasses the ATP-requiring steps of glycolysis [75,96].


Negative_regulation (inhibition) of MPTP associated with parkinson's disease
4) Confidence 0.34 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 1.36 Pain Relevance 0
However, such experiments are hard to interpret since incubating isolated mitochondria in vitro can change the sensitivity of MPTP opening to calcium, especially if ATP is added since this is an inhibitor of MPTP opening in its own right [3,40].
Negative_regulation (inhibitor) of MPTP associated with parkinson's disease
5) Confidence 0.34 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.82 Pain Relevance 0.07
These effects of MPTP were almost abolished in the presence of nomifensine.
Negative_regulation (abolished) of MPTP associated with parkinson's disease
6) Confidence 0.34 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6335691 Disease Relevance 0.40 Pain Relevance 0.16
HCT1026 inhibits MPTP-induced motor impairment
Negative_regulation (inhibits) of MPTP associated with parkinson's disease
7) Confidence 0.33 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 1.06 Pain Relevance 0.04
Blockade of PrRP attenuates MPTP-induced toxicity in mice.
Negative_regulation (Blockade) of MPTP associated with parkinson's disease and toxicity
8) Confidence 0.31 Published 2009 Journal Peptides Section Title Doc Link 19540425 Disease Relevance 0.74 Pain Relevance 0.16
At day 1 post-MPTP injection (Fig. 6B &7B), a marked reduction in spontaneous activity was observed (***p < 0.001).
Negative_regulation (reduction) of MPTP associated with parkinson's disease
9) Confidence 0.31 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1440849 Disease Relevance 0.70 Pain Relevance 0.15
Both inhibition of COX-2 and genetic deficiency of COX-2 reduced SNpc microglial activation and mitigated MPTP-induced neurotoxicity on dopaminergic neurons in the SNpc.


Negative_regulation (inhibition) of MPTP in dopaminergic neurons associated with parkinson's disease and drug induced neurotoxicity
10) Confidence 0.31 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1440849 Disease Relevance 1.57 Pain Relevance 0.23
COX-2 deficiency attenuates MPTP-induced loss of TH-positive neurons and neuronal terminals in the nigrostriatal system
Negative_regulation (deficiency) of MPTP in neurons associated with parkinson's disease
11) Confidence 0.31 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1440849 Disease Relevance 0.93 Pain Relevance 0.04
To determine whether valdecoxib could prevent not only MPTP-induced loss of SNpc dopaminergic neurons but also the loss of striatal dopaminergic fibers, we assessed the density of TH immunoreactivity in the striata of the different mice (Fig. 1E).
Negative_regulation (prevent) of MPTP in dopaminergic neurons associated with parkinson's disease
12) Confidence 0.31 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1440849 Disease Relevance 0.97 Pain Relevance 0
We defined this as basal microglial activation; however, we did observe a significant reduction in MPTP-induced microglial activation in the COX-2 KO and inhibitor-treated mice relative to the MPTP-treated WT mice.
Negative_regulation (reduction) of MPTP associated with targeted disruption and parkinson's disease
13) Confidence 0.31 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1440849 Disease Relevance 1.34 Pain Relevance 0.10
Thus free radical scavengers are well known to be protective and in the case of one such agent, the anaesthetic propofol, we have used the 2-deoxyglucose entrapment technique to confirm inhibition of the MPTP directly [92].
Negative_regulation (inhibition) of MPTP associated with parkinson's disease
14) Confidence 0.30 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.98 Pain Relevance 0
This protection probably reflects less sodium and hence calcium loading of the cardiac myocytes during ischaemia, coupled with a lower pH during the initial phase of reperfusion, both of which will reduce MPTP opening.
Negative_regulation (reduce) of MPTP in cardiac myocytes associated with parkinson's disease and cv unclassified under development
15) Confidence 0.30 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 1.21 Pain Relevance 0
Temperature preconditioning, where hearts are exposed to three brief hypothermic (26 °C) episodes prior to normothermic ischaemia is also thought to protect through inhibition of the MPTP [101] as is post-conditioning [102].
Negative_regulation (inhibition) of MPTP in hearts associated with parkinson's disease and cv unclassified under development
16) Confidence 0.30 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.81 Pain Relevance 0.06
Signalling pathways linking preconditioning to inhibition of the MPTP
Negative_regulation (inhibition) of MPTP associated with parkinson's disease
17) Confidence 0.30 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.74 Pain Relevance 0.08
Since IP involves inhibition of the MPTP the signalling pathway must ultimately inhibit MPTP opening, but this could be achieved either by direct phosphorylation of a component of the MPTP or indirectly by influencing factors that enhance pore opening such as by reducing oxidative stress or calcium overload.


Negative_regulation (inhibition) of MPTP in pore associated with stress and parkinson's disease
18) Confidence 0.30 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 1.06 Pain Relevance 0.13
Thus opening of the MPTP is inhibited by adenine nucleotides with a similar concentration dependence and specificity as they exhibit when acting as substrates for the ANT, and this inhibition is overcome by the specific inhibitor of the ANT, carboxyatractyloside (CAT) that traps the ANT in its “c” conformation.
Negative_regulation (inhibited) of MPTP associated with parkinson's disease, addiction and tumor necrosis factor receptor-associated periodic syndrome
19) Confidence 0.30 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.57 Pain Relevance 0.08
Baines et al. have reported that the MPTP of isolated heart mitochondria was inhibited following incubation for 15 min with purified PKC?
Negative_regulation (inhibited) of MPTP in heart associated with parkinson's disease and kinase c
20) Confidence 0.30 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.76 Pain Relevance 0.14

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