INT43903

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Context Info
Confidence 0.41
First Reported 1984
Last Reported 2011
Negated 5
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 15.51
Pain Relevance 4.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Ptpn2) endoplasmic reticulum (Ptpn2) nucleus (Ptpn2)
cytoplasm (Ptpn2)
Anatomy Link Frequency
pore 2
myocardium 1
caudate nucleus 1
outflow 1
putamen 1
Ptpn2 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 34 100.00 Very High Very High Very High
midbrain 66 99.84 Very High Very High Very High
ischemia 40 99.20 Very High Very High Very High
Inflammatory mediators 13 96.88 Very High Very High Very High
Dopamine 111 95.08 Very High Very High Very High
Eae 17 93.88 High High
potassium channel 228 92.80 High High
monoamine 17 89.12 High High
dopaminergic neurodegeneration 14 85.76 High High
Substantia nigra 88 85.44 High High
Disease Link Frequency Relevance Heat
Parkinson's Disease 1303 100.00 Very High Very High Very High
Dyskinesias 16 99.76 Very High Very High Very High
Injury 54 99.74 Very High Very High Very High
Cv Unclassified Under Development 237 99.20 Very High Very High Very High
Aging 93 98.28 Very High Very High Very High
Stress 152 97.76 Very High Very High Very High
INFLAMMATION 191 96.48 Very High Very High Very High
Death 160 96.44 Very High Very High Very High
Apoptosis 74 96.00 Very High Very High Very High
Shock 16 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No relevant effect of MPTP on adenylate cyclase activity in homogenates and on basal and electrically evoked tritium outflow from [3H]choline-prelabeled slices of rat striatum could be detected.
Neg (No) Regulation (effect) of MPTP in outflow associated with parkinson's disease
1) Confidence 0.41 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6335691 Disease Relevance 0.58 Pain Relevance 0.32
Mg/H2 water and its effect on acute MPTP model mice
Regulation (effect) of MPTP associated with parkinson's disease
2) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.61 Pain Relevance 0
The effect of H2 water in chronic MPTP infusion model
Regulation (effect) of MPTP associated with parkinson's disease
3) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 1.35 Pain Relevance 0
For MPTP chronic model, treatment with H2 or non-H2 water continued after MPTP administration.


Regulation (continued) of MPTP associated with parkinson's disease
4) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.86 Pain Relevance 0.08
To verify the ability of HCT1026 to affect MPTP-induced impairment of motor coordination [42,79,80], we assessed the ability to maintain the balance on a rotating cylinder and to adapt to the rate of locomotor activity, by using the Rotarod test, as described (Figure 1D).
Regulation (affect) of MPTP associated with parkinson's disease and eae
5) Confidence 0.35 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 1.06 Pain Relevance 0.05
The ability of a preventive treatment with HCT1026 to inhibit MPTP-induced up-regulation of iNOS was next evaluated by semi-quantitative RT-PCR analysis 1 d after MPTP challenge.
Regulation (regulation) of MPTP associated with parkinson's disease
6) Confidence 0.35 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.69 Pain Relevance 0.27
Moreover, valdecoxib does not affect the movement of mice pre-MPTP treatment.
Neg (not) Regulation (affect) of MPTP associated with parkinson's disease
7) Confidence 0.32 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1440849 Disease Relevance 0.71 Pain Relevance 0.08
The properties and regulation of the MPTP are reviewed extensively elsewhere [3,40,41].
Regulation (regulation) of MPTP in MPTP associated with parkinson's disease
8) Confidence 0.31 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.58 Pain Relevance 0
Hence it seems probable that CsA and SfA are overcoming IP independently of any effects on MPTP opening.
Regulation (effects) of MPTP associated with parkinson's disease
9) Confidence 0.23 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.78 Pain Relevance 0
MPTP metabolism is not affected by HCT1026 preventive treatment
Neg (not) Regulation (affected) of MPTP associated with parkinson's disease
10) Confidence 0.18 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 1.22 Pain Relevance 0.04
Following a brief overview of the molecular characterisation and regulation of the MPTP, the proposed mechanisms by which IP reduces pore opening are reviewed including the potential roles for reactive oxygen species (ROS), protein kinase cascades, and mitochondrial potassium channels.
Regulation (regulation) of MPTP in pore associated with parkinson's disease and potassium channel
11) Confidence 0.14 Published 2007 Journal Biochimica et Biophysica Acta Section Abstract Doc Link PMC2212780 Disease Relevance 1.07 Pain Relevance 0.05
Effect of NDI1 Expression on Behavior Following either Saline or MPTP Treatment
Regulation (Effect) of MPTP associated with parkinson's disease
12) Confidence 0.13 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3005838 Disease Relevance 0.29 Pain Relevance 0.14
However, it is not yet known whether functioning of the MPTP is altered in the aged myocardium, and the function of the MPTP has not been thoroughly elucidated.
Regulation (altered) of MPTP in myocardium associated with parkinson's disease
13) Confidence 0.11 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872846 Disease Relevance 0.75 Pain Relevance 0.03
For example, no differences have been observed between the neurotoxic effect of MPTP in midbrain-DA cells of calbindin-D28k-deficient mice and their wild-type littermates (Airaksinen et al., 1997).
Regulation (effect) of MPTP in midbrain associated with parkinson's disease and midbrain
14) Confidence 0.09 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2978035 Disease Relevance 0.17 Pain Relevance 0.22
reduces ischemia/reperfusion cardiac injury through the regulation of the mPTP opening, indicating that it could exert its functions by modulating mitochondrial activity [29]–[32].
Regulation (regulation) of mPTP associated with ischemia and injury
15) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 1.25 Pain Relevance 0.14
exerts its functions via the mitochondrial activity, by modulating transport through the outer membrane of the mitochondria, regulating the opening of the mPTP or mediating the access of Bax to the mitochondria [27], [31], [40].
Regulation (regulating) of mPTP
16) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0 Pain Relevance 0
has also been described to be involved in the regulation of opening of the mPTP, an event that can occur under conditions of oxidative stress or electron transport chain inhibition, leading to collapse of the mitochondrial membrane potential [30], [56], [57].
Regulation (regulation) of mPTP associated with stress and shock
17) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 1.16 Pain Relevance 0
Repeated treatment with L-DOPA for 30 days produced marked dyskinesia but had no effect on the MPTP-induced increase in PPE-A mRNA in the caudate nucleus and putamen.
Neg (no) Regulation (effect) of MPTP in caudate nucleus associated with parkinson's disease and dyskinesias
18) Confidence 0.06 Published 2002 Journal Neuroscience Section Abstract Doc Link 12453478 Disease Relevance 1.19 Pain Relevance 0.07
Repeated treatment with L-DOPA for 30 days produced marked dyskinesia but had no effect on the MPTP-induced increase in PPE-A mRNA in the caudate nucleus and putamen.
Neg (no) Regulation (effect) of MPTP in putamen associated with parkinson's disease and dyskinesias
19) Confidence 0.02 Published 2002 Journal Neuroscience Section Abstract Doc Link 12453478 Disease Relevance 1.19 Pain Relevance 0.07
Morphine prevented oxidant-induced loss of DeltaPsi(m), indicating that morphine can modulate the mPTP opening.
Regulation (modulate) of mPTP associated with morphine
20) Confidence 0.01 Published 2010 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 19966058 Disease Relevance 0 Pain Relevance 1.23

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