INT43906

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Context Info
Confidence 0.53
First Reported 1984
Last Reported 2011
Negated 10
Speculated 14
Reported most in Body
Documents 71
Total Number 86
Disease Relevance 35.18
Pain Relevance 15.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Anatomy Link Frequency
lung 6
macrophages 4
microglia 4
brain 2
dentate gyrus 1
Tlr4 (Mus musculus)
Tlr4 - D299G (1)
Pain Link Frequency Relevance Heat
Inflammatory response 219 100.00 Very High Very High Very High
Desipramine 49 100.00 Very High Very High Very High
fluoxetine 47 100.00 Very High Very High Very High
Inflammatory stimuli 38 100.00 Very High Very High Very High
Neuropathic pain 28 100.00 Very High Very High Very High
Thermal hyperalgesia 26 100.00 Very High Very High Very High
addiction 11 100.00 Very High Very High Very High
Neurobehavioral 2 99.96 Very High Very High Very High
chemokine 188 99.88 Very High Very High Very High
aspirin 13 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1661 100.00 Very High Very High Very High
Hyperalgesia 59 100.00 Very High Very High Very High
Neuropathic Pain 52 100.00 Very High Very High Very High
Pseudomonas Infection 22 100.00 Very High Very High Very High
Metastasis 142 99.96 Very High Very High Very High
Fever 61 99.96 Very High Very High Very High
Apoptosis 158 99.84 Very High Very High Very High
Ischemic Heart Disease 6 99.84 Very High Very High Very High
Cv General 2 Under Development 57 99.64 Very High Very High Very High
Pulmonary Disease 23 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It regulates TLR4 signalling in various immune cells as well as in mice challenged with intraperitoneal E. coli LPS.
Regulation (regulates) of TLR4 in immune cells
1) Confidence 0.53 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.19 Pain Relevance 0
Although the present study could not confirm whether the local TLR signal affects the systemic TLR4 signal, monoyctic activation of both systemic and local TLR4 signals may be associated with the incidence of cardiac events in patients with AMI.
Spec (whether) Regulation (affects) of TLR4
2) Confidence 0.52 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0.46 Pain Relevance 0.40
Those data raise at least 2 hypotheses; first, modulation of TLR, in particular TLR4, could be a strategy in the management of chronic pain.
Regulation (modulation) of TLR4 associated with lasting pain
3) Confidence 0.46 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.73 Pain Relevance 1.47
To define the effect of TLR4 ligand on the host defense to bacteria challenge, we harvested peritoneal cells from mice after oral antibiotics and examined the bacterial killing activity of cells.
Regulation (effect) of TLR4
4) Confidence 0.45 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 1.14 Pain Relevance 0.04
Changes in TLR2 and TLR4 levels in response to HSP70
Regulation (Changes) of TLR4
5) Confidence 0.43 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0.09 Pain Relevance 0
Tlr4 is a candidate for inflammatory response and neuropathic pain (Poltorak et al. 1998; Tanga et al. 2005) and very plausible as a gene whose regulation is linked to Cckbr.
Regulation (regulation) of Tlr4 associated with inflammatory response and neuropathic pain
6) Confidence 0.43 Published 2007 Journal Genes, Brain, and Behavior Section Body Doc Link PMC1890814 Disease Relevance 0.45 Pain Relevance 0.28
The lack of association can be explained by recent publications showing that heterozygous carriage of the TLR4 Asp299Gly mutation does not affect LPS responsiveness and that only the rare homozygous carriers are less responsive to LPS[18].
Neg (not) Regulation (affect) of LPS
7) Confidence 0.42 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1351185 Disease Relevance 0.38 Pain Relevance 0.03
For example, we have shown that Cox-2 expression is dependent on TLR4 and that, in the absence of TLR4, levels of PGE 2 are greatly reduced.
Regulation (dependent) of TLR4
8) Confidence 0.41 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912804 Disease Relevance 0.98 Pain Relevance 0.08
Many studies have documented capacities of new drugs to regulate TLR4 signalling and expression.
Regulation (regulate) of TLR4
9) Confidence 0.39 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.44 Pain Relevance 0.10
In the present study, we investigated the effects of TLR4 (Asp299Gly, Thr399Ile) polymorphisms on gastroduodenal diseases in Japanese population.


Spec (investigated) Regulation (effects) of TLR4 (D299G) associated with disease
10) Confidence 0.39 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291505 Disease Relevance 0.44 Pain Relevance 0
The supernatants from stromal cells accumulated IL-6, CXCL1, CCL20, and PGE in a concentration dependent manner for each LPS examined (Fig. 5A–D; ANOVA, P<0.05).
Spec (examined) Regulation (dependent) of LPS in stromal cells
11) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943929 Disease Relevance 0.32 Pain Relevance 0.19
The supernatants from epithelial cells also accumulated IL-6, CXCL1, and CCL20, in a concentration dependent manner for each LPS examined (Fig. 5E–G; ANOVA, P<0.05), although the epithelial cells secreted little PGE (Fig. 5H).
Spec (examined) Regulation (dependent) of LPS in epithelial cells
12) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943929 Disease Relevance 0.34 Pain Relevance 0.20
CD14, a 55-kDa glycoprotein predominantly expressed on the surface of myeloid cells via a glycosylphosphatidyl anchor, associates with the TLR4/MD-2 complex and transfer LPS monomers to TLR4/MD-2 [8].
Regulation (transfer) of LPS in myeloid cells
13) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.15 Pain Relevance 0.16
Although our study does not elucidate the mechanism underlying this intriguing finding, we did demonstrate that high dose S-LPS (Fig. 4) and R-LPS (data not shown) induce the release of sCD14 in WT mice, which may down-regulate further LPS-induced inflammatory processes.
Spec (may) Regulation (regulate) of LPS associated with inflammation
14) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.19 Pain Relevance 0.13
The effects of LPS treatment appeared to be more robust in male rats, as far as suppression of locomotor activity is concerned, while the antinociceptive properties of LPS were evident in both sexes though showing sex-dependent kinetics.
Regulation (effects) of LPS associated with eae and antinociceptive
15) Confidence 0.38 Published 2009 Journal Neuroscience Section Abstract Doc Link 19409213 Disease Relevance 0.32 Pain Relevance 0.43
These results are corroborated by studies showing the role of the CD14-TLR4-MD2 complex in intracellular signalling by LPS[13,37] and studies showing the dependency on CD14 of phagocytosis of Gram negative bacteria [38].
Regulation (role) of TLR4 in MD2
16) Confidence 0.36 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1351185 Disease Relevance 0.67 Pain Relevance 0.18
The data verifies the efficacy of PLGA-PEG mediated PS-341 drug delivery in controlling Pa-LPS induced lung disease in CF mice.
Regulation (controlling) of Pa-LPS in lung associated with pseudomonas infection and pulmonary disease
17) Confidence 0.35 Published 2010 Journal J Nanobiotechnology Section Body Doc Link PMC2954907 Disease Relevance 1.19 Pain Relevance 0.16
Another hypothesis on the effect of statin on TLR expression is its potential influence on TLR4 membrane trafficking in treated subjects because of altered cholesterol rich membrane domains, as observed in brain plasma membranes [78].
Regulation (influence) of TLR4 in brain
18) Confidence 0.34 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.30 Pain Relevance 0.05
Data on the effect of LPS application on already ventilated lungs are sparse.
Regulation (effect) of LPS in lungs
19) Confidence 0.34 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2873469 Disease Relevance 0.55 Pain Relevance 0.26
Effect of LPS and PAM3 on oxygen saturation and heart rate
Regulation (Effect) of LPS in heart
20) Confidence 0.34 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2873469 Disease Relevance 0.08 Pain Relevance 0.11

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