INT4391

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Context Info
Confidence 0.78
First Reported 1975
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 47
Total Number 54
Disease Relevance 41.43
Pain Relevance 9.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINA1) extracellular region (SERPINA1) proteinaceous extracellular matrix (SERPINA1)
Anatomy Link Frequency
liver 6
plasma 3
hepatocyte 3
neuron 3
epithelial cells 2
SERPINA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 14 100.00 Very High Very High Very High
Migraine 5 100.00 Very High Very High Very High
spastic colon 2 100.00 Very High Very High Very High
cytokine 88 99.72 Very High Very High Very High
spinal inflammation 435 99.52 Very High Very High Very High
fibrosis 37 99.20 Very High Very High Very High
Inflammation 289 99.14 Very High Very High Very High
rheumatoid arthritis 214 98.16 Very High Very High Very High
Inflammatory mediators 23 97.80 Very High Very High Very High
Potency 138 97.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 62 100.00 Very High Very High Very High
Alpha-1-antitrypsin Deficiency 52 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

9 100.00 Very High Very High Very High
Migraine With Aura 5 100.00 Very High Very High Very High
Functional Bowel Disorder 2 100.00 Very High Very High Very High
Disease 427 99.90 Very High Very High Very High
Pulmonary Disease 220 99.90 Very High Very High Very High
Nicotine Addiction 84 99.90 Very High Very High Very High
Liver Disease 72 99.90 Very High Very High Very High
Cancer 92 99.86 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alpha-1-antitrypsin is also produced by monocytes and lung epithelial cells, and therefore there is also production present in the lung [5].
Gene_expression (produced) of Alpha-1-antitrypsin in epithelial cells
1) Confidence 0.78 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2441617 Disease Relevance 0.34 Pain Relevance 0.20
It is observed that cigarette smokers who produce no alpha-1-antitrypsin at all in their liver or in monocytes, defined as individuals with the very rare homozygous Null variant, develop emphysema at younger age than subjects with the homozygous Z allele related deficiency [17].
Neg (no) Gene_expression (produce) of alpha-1-antitrypsin in monocytes associated with emphysema and nicotine addiction
2) Confidence 0.78 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2441617 Disease Relevance 1.50 Pain Relevance 0.07
The protein alpha-1-antitrypsin is a 52 kDa molecule produced primarily in hepatocytes and released into the blood circulation by the liver [5].
Gene_expression (produced) of alpha-1-antitrypsin in liver
3) Confidence 0.78 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2441617 Disease Relevance 0.91 Pain Relevance 0.08
Serum alpha1-AT levels and neutralizing elastase activity were measured preinfusion, postinfusion, and at nadir.
Gene_expression (levels) of alpha1-AT
4) Confidence 0.75 Published 1997 Journal Chest Section Body Doc Link 9315791 Disease Relevance 0 Pain Relevance 0
Immunohistochemically, most tumor cells expressed vimentin, alpha-1 anti-chymotrypsin, alpha-1 antitrypsin and CD68.
Gene_expression (expressed) of alpha-1 antitrypsin associated with cancer
5) Confidence 0.74 Published 2007 Journal Histol. Histopathol. Section Abstract Doc Link 17701913 Disease Relevance 0.86 Pain Relevance 0.09
Immunohistochemically, most tumor cells expressed vimentin, alpha-1 anti-chymotrypsin, alpha-1 antitrypsin and CD68.
Gene_expression (expressed) of alpha-1 anti-chymotrypsin associated with cancer
6) Confidence 0.74 Published 2007 Journal Histol. Histopathol. Section Abstract Doc Link 17701913 Disease Relevance 0.86 Pain Relevance 0.09
Hereditary alpha-1-antitrypsin deficiency and its clinical consequences

Alpha-1-antitrypsin deficiency (AATD) is a genetic disorder that manifests as pulmonary emphysema, liver cirrhosis and, rarely, as the skin disease panniculitis, and is characterized by low serum levels of AAT, the main protease inhibitor (PI) in human serum.

Gene_expression (deficiency) of alpha-1-antitrypsin in liver associated with cirrhosis, skin diseases, pulmonary emphysema and panniculitis
7) Confidence 0.68 Published 2008 Journal Orphanet J Rare Dis Section Title Doc Link PMC2441617 Disease Relevance 0.80 Pain Relevance 0
Hereditary alpha-1-antitrypsin deficiency and its clinical consequences

Alpha-1-antitrypsin deficiency (AATD) is a genetic disorder that manifests as pulmonary emphysema, liver cirrhosis and, rarely, as the skin disease panniculitis, and is characterized by low serum levels of AAT, the main protease inhibitor (PI) in human serum.

Gene_expression (deficiency) of Alpha-1-antitrypsin in liver associated with cirrhosis, skin diseases, pulmonary emphysema and panniculitis
8) Confidence 0.68 Published 2008 Journal Orphanet J Rare Dis Section Title Doc Link PMC2441617 Disease Relevance 0.82 Pain Relevance 0
The homozygous S variant of alpha-1-antitrypsin results in an instable protein that is easily degraded outside the hepatocyte and affects the half-life of the S variant [30].
Gene_expression (results) of alpha-1-antitrypsin in hepatocyte
9) Confidence 0.68 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2441617 Disease Relevance 0.10 Pain Relevance 0
Liver disease and alpha-1-antitrypsin deficiency
Gene_expression (deficiency) of alpha-1-antitrypsin in Liver associated with liver disease
10) Confidence 0.68 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2441617 Disease Relevance 0.98 Pain Relevance 0.03
Skin disorders and alpha-1-antitrypsin deficiency
Gene_expression (deficiency) of alpha-1-antitrypsin in Skin
11) Confidence 0.68 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2441617 Disease Relevance 1.17 Pain Relevance 0.08
Lung disease and alpha-1-antitrypsin deficiency
Gene_expression (deficiency) of alpha-1-antitrypsin in Lung associated with pulmonary disease
12) Confidence 0.68 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2441617 Disease Relevance 1.86 Pain Relevance 0.04
There is consensus in the scientific community on how to test, expressed in an ATS/ERS Statement on the diagnosis and treatment of alpha-1-antitrypsin deficiency [10].
Gene_expression (expressed) of alpha-1-antitrypsin
13) Confidence 0.68 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2441617 Disease Relevance 0.72 Pain Relevance 0.04
Who should be tested how for alpha-1-antitrypsin deficiency?
Gene_expression (deficiency) of alpha-1-antitrypsin
14) Confidence 0.68 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2441617 Disease Relevance 0.61 Pain Relevance 0.03
Alpha-1-antitrypsin is an acute phase protein which means that production by the liver is subject to various stimuli, including inflammatory mediators induced by fever [2].
Gene_expression (production) of Alpha-1-antitrypsin in liver associated with inflammatory mediators and fever
15) Confidence 0.68 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2441617 Disease Relevance 0.85 Pain Relevance 0.09
The aim of this study was to investigate the pharmacokinetic characteristics of Prolastin-C in individuals with AAT deficiency and to compare these characteristics with those of Prolastin in support of licensing Prolastin-C.
Gene_expression (deficiency) of AAT
16) Confidence 0.65 Published 2010 Journal BMC Clin Pharmacol Section Body Doc Link PMC2958874 Disease Relevance 0 Pain Relevance 0
Immunohistochemistry study showed that the tumor cells were reactive with hepatocyte antigen (Hep par 1), alpha-1 antitrypsin, but negative for synaptophysin and chromogranin.
Neg (negative) Gene_expression (reactive) of alpha-1 antitrypsin in hepatocyte associated with cancer
17) Confidence 0.64 Published 2007 Journal Virchows Arch. Section Abstract Doc Link 17216188 Disease Relevance 0.88 Pain Relevance 0.21
These modifications to the Prolastin manufacturing process have led to the development of an alpha1-PI product, designated Prolastin®-C (Alpha1-Proteinase Inhibitor [Human]), with increased purity, a higher concentration of active alpha1-PI, and, as demonstrated in laboratory studies, a higher margin of safety from the risk of transmission of infectious pathogens.
Gene_expression (product) of alpha1-PI in margin
18) Confidence 0.60 Published 2010 Journal BMC Clin Pharmacol Section Body Doc Link PMC2958874 Disease Relevance 0 Pain Relevance 0
It has previously been shown that some alpha1-PI preparations have a higher antigenic content than functionally active content, which results in differences in the specific activity of alpha1-PI products.
Gene_expression (products) of alpha1-PI
19) Confidence 0.60 Published 2010 Journal BMC Clin Pharmacol Section Body Doc Link PMC2958874 Disease Relevance 0 Pain Relevance 0
It was suggested that the increasing levels of A1AT and A1AChy during chemotherapy after radical surgery for gastric cancer may point to the progress of the disease.
Gene_expression (levels) of A1AT associated with alpha-1-antitrypsin deficiency, disease and stomach cancer
20) Confidence 0.59 Published 1993 Journal Neoplasma Section Abstract Doc Link 7688868 Disease Relevance 0.86 Pain Relevance 0.16

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