INT43926

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Context Info
Confidence 0.65
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 5.01
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SUCLA2) small molecule metabolic process (SUCLA2) ligase activity (SUCLA2)
Anatomy Link Frequency
neuron 1
cleavage 1
plaques 1
SUCLA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatosensory cortex 55 100.00 Very High Very High Very High
Enkephalin 4 100.00 Very High Very High Very High
primary somatosensory cortex 34 98.64 Very High Very High Very High
Somatostatin 2 98.32 Very High Very High Very High
narcan 4 96.48 Very High Very High Very High
Arthritis 1 95.88 Very High Very High Very High
cINOD 1 94.00 High High
opiate 2 75.00 Quite High
Opioid 2 75.00 Quite High
ischemia 1 73.72 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 26 98.32 Very High Very High Very High
Disease 121 98.24 Very High Very High Very High
Apoptosis 100 97.84 Very High Very High Very High
Death 28 97.52 Very High Very High Very High
Amyloid Plaque 9 96.52 Very High Very High Very High
Arthritis 1 95.88 Very High Very High Very High
INFLAMMATION 2 93.76 High High
Neurodegenerative Disease 12 89.60 High High
Amnesia 4 88.72 High High
Attention Deficit Hyperactivity Disorder 95 87.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[A method for the evaluation of resource use in cardiac surgery: application of the ICR beta in an Italian reality].
Gene_expression (application) of ICR beta
1) Confidence 0.65 Published 1998 Journal Cardiologia Section Title Doc Link 9701882 Disease Relevance 0.11 Pain Relevance 0.06
The formation of the plaques is due to an overproduction of A-beta through enzymatic cleavage of the larger amyloid protein precursor (APP).
Gene_expression (overproduction) of A-beta in cleavage associated with alzheimer's dementia
2) Confidence 0.16 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2871552 Disease Relevance 1.23 Pain Relevance 0
For successive experiments we selected the A-beta oligomer and insulin concentrations at 40 and 100??
Gene_expression (oligomer) of A-beta
3) Confidence 0.14 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2871552 Disease Relevance 0.25 Pain Relevance 0
As a result, a large amount of A-beta toxic fragments is produced and deposited as plaques.
Gene_expression (produced) of A-beta in plaques
4) Confidence 0.14 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2871552 Disease Relevance 1.24 Pain Relevance 0
Presence of A-beta produces a toxic effect, responsible for the observed neuron death.
Gene_expression (Presence) of A-beta in neuron associated with death
5) Confidence 0.14 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2871552 Disease Relevance 0.91 Pain Relevance 0
This review will focus on the interrelationships between the mechanisms of PS1, PS2 and betaAPP gene expression, tau and betaA deposition and the induction, regulation and proliferation in AD of the neuroinflammatory response.
Gene_expression (expression) of betaA associated with disease
6) Confidence 0.12 Published 2000 Journal Neurochem. Res. Section Abstract Doc Link 11059791 Disease Relevance 0.97 Pain Relevance 0.23
The following compounds were inactive at 9 nmol/kg BW: N-acetyl-beta h-endorphin; N-acetyl-arg-beta h-endorphin; beta h-endorphin2-31; beta h-endorphin6-31; beta h-endorphin(((1-5 + 6-31))); beta h-endorphin1-18 (gamma-endorphin); beta h-endorphin1-17 (alpha-endorphin); beta h-endorphin1-5 (met-enkephalin); leu5-beta h-endorphin (leu-enkephalin); met-NH2(5)-beta h-endorphin1-5 (met-enkephalinamide); D-ala2-leu5-beta h-endorphin1-5; D-ala2-N-me-phe4, met-(O)5-ol-beta h-endorphin1-5; and D-ala2-D-leu5-beta h-endorphin1-5.
Gene_expression (inactive) of leu5-beta associated with enkephalin
7) Confidence 0.01 Published 1983 Journal Endocrinology Section Abstract Doc Link 6339212 Disease Relevance 0 Pain Relevance 0.51
The following compounds were inactive at 9 nmol/kg BW: N-acetyl-beta h-endorphin; N-acetyl-arg-beta h-endorphin; beta h-endorphin2-31; beta h-endorphin6-31; beta h-endorphin(((1-5 + 6-31))); beta h-endorphin1-18 (gamma-endorphin); beta h-endorphin1-17 (alpha-endorphin); beta h-endorphin1-5 (met-enkephalin); leu5-beta h-endorphin (leu-enkephalin); met-NH2(5)-beta h-endorphin1-5 (met-enkephalinamide); D-ala2-leu5-beta h-endorphin1-5; D-ala2-N-me-phe4, met-(O)5-ol-beta h-endorphin1-5; and D-ala2-D-leu5-beta h-endorphin1-5.
Gene_expression (inactive) of leu5-beta associated with enkephalin
8) Confidence 0.01 Published 1983 Journal Endocrinology Section Abstract Doc Link 6339212 Disease Relevance 0 Pain Relevance 0.46
In the control group, SII exhibited strong early ERS from 5 Hz to 25 Hz followed by ERD and beta rebound ERS, consistent with the control Random SII response.
Gene_expression (response) of beta rebound associated with somatosensory cortex
9) Confidence 0.01 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2266931 Disease Relevance 0.30 Pain Relevance 0.67

General Comments

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