INT43931

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Context Info
Confidence 0.48
First Reported 1983
Last Reported 2010
Negated 2
Speculated 4
Reported most in Body
Documents 49
Total Number 54
Disease Relevance 31.85
Pain Relevance 3.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CFH) extracellular region (CFH)
Anatomy Link Frequency
heart 2
body 2
caudate nucleus 1
plasma 1
colon 1
CFH (Homo sapiens)
CFH - Y402H (1)
Pain Link Frequency Relevance Heat
headache 63 100.00 Very High Very High Very High
Analgesic 2 99.32 Very High Very High Very High
abdominal pain 4 98.94 Very High Very High Very High
metalloproteinase 10 97.32 Very High Very High Very High
Inflammation 118 93.92 High High
cINOD 6 92.08 High High
ischemia 7 91.04 High High
cva 23 85.72 High High
Pain 16 83.36 Quite High
Arthritis 68 81.32 Quite High
Disease Link Frequency Relevance Heat
Myocardial Infarction 223 100.00 Very High Very High Very High
Hemolytic Uremic Syndrome 118 100.00 Very High Very High Very High
Coronary Artery Disease 73 100.00 Very High Very High Very High
Headache 61 100.00 Very High Very High Very High
Colitis 8 99.96 Very High Very High Very High
Infection 383 99.90 Very High Very High Very High
Lyme Disease 763 99.78 Very High Very High Very High
Dengue 208 99.78 Very High Very High Very High
Diarrhoea 11 99.68 Very High Very High Very High
Age-related Macular Degeneration 231 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Likewise, in their study of 1170 patients with angiographically confirmed coronary artery disease and 560 controls, Goverdhan and co-workers did not detect any association between the CFH Y402H gene variant and presence or severity of CAD [13].
CFH Y402H gene (Y402H) Neg (not) Binding (association) of in coronary artery associated with coronary artery disease
1) Confidence 0.48 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2048938 Disease Relevance 1.02 Pain Relevance 0.13
It is tempting to speculate that such an effect might be mediated by an interaction between factor H and the factor H-related proteins.


factor H Binding (interaction) of
2) Confidence 0.48 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1626556 Disease Relevance 0.43 Pain Relevance 0
CFH is common and associated with overuse of analgesics, psychopathology, smoking, sleeping problems, a history of head/neck trauma and low educational level.
CFH Binding (associated) of in neck associated with nicotine addiction, analgesic, injury and headache
3) Confidence 0.47 Published 2006 Journal Cephalalgia Section Abstract Doc Link 17116093 Disease Relevance 1.41 Pain Relevance 1.30
Mutations reported in association with aHUS include c.3572C>T, which results in the change S1191L and c.3590T>C, which results in V1197A, either singly or in combination [6–8].
aHUS Binding (association) of
4) Confidence 0.42 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1626556 Disease Relevance 0 Pain Relevance 0
It is tempting to speculate that such an effect might be mediated by an interaction between factor H and the factor H-related proteins.


factor H Binding (interaction) of
5) Confidence 0.37 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1626556 Disease Relevance 0.43 Pain Relevance 0
The forward primers were designed to be specific for CFH and were therefore sited in exon 20, which is not homologous to CFHL1.
CFH Binding (specific) of
6) Confidence 0.37 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1626556 Disease Relevance 0 Pain Relevance 0
In this family-based study, we found no association between the CFH gene and early-onset coronary heart disease.



CFH gene Neg (no) Binding (association) of in heart associated with coronary artery disease
7) Confidence 0.36 Published 2007 Journal BMC Med Genet Section Abstract Doc Link PMC2048938 Disease Relevance 0.56 Pain Relevance 0
Because there are no complement regulatory proteins – which usually inhibit complement activation on eukaryotic cells – present on the cartilage surface and because the bound IgGs are able to bind C3b and prevent the binding of the complement regulatory plasma proteins factor I and factor H, formation of the C3 convertase is possible.
factor H Binding (binding) of in plasma
8) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 0.82 Pain Relevance 0.22
This was because the exact type of mutation would help them predict whether a kidney transplant is likely to be successful in treating an individual with aHUS who has developed kidney failure.
aHUS Binding (individual) of in kidney associated with renal failure
9) Confidence 0.33 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1626556 Disease Relevance 0.37 Pain Relevance 0
Binding of CFH to human cells is initially mediated by the C-terminal domains SCR19 and 20, which then leads to an uncoiling of the protein and exposure of other CFH domains to additional cell-surface receptors [13], [53]–[55].
CFH Binding (Binding) of
10) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 0.09 Pain Relevance 0
Conceivably, the writhing of live spirochetes may dislodge long, extended and weakly bound CFH molecules from the bacterial surface, whereas the much smaller serum proteins CFHR1, CFHR2, and CFHR5 are more likely to be retained.
CFH Binding (bound) of
11) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 0.07 Pain Relevance 0
To analyze binding of CFH to transformed borreliae by flow cytometry 2×108 cells grown to mid-log phase were washed with PBS and subsequently incubated in 300 µl PBS containing 4 µg purified CFH (Calbiochem) for 60 min at room temperature.
CFH Spec (analyze) Binding (binding) of
12) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 0 Pain Relevance 0
Recognition of a drug-induced HUS is necessary to avoid reexposure and recurrent HUS.
HUS Binding (Recognition) of associated with hemolytic uremic syndrome
13) Confidence 0.30 Published 2007 Journal Clin. Nephrol. Section Abstract Doc Link 17915621 Disease Relevance 1.15 Pain Relevance 0.17
Moreover, CFH improperly bound to the borrelial surface appears to be unable to efficiently inactivate deposited C3b or accelerate the decay of the formed C3 convertase after activation of the complement cascade.
CFH Binding (bound) of
14) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 0 Pain Relevance 0
Complement factor H (CFH) inhibits the complement cascade that ensures the system is directed against pathogens and not the body's own tissues, and is a major susceptibility gene in AMD.
CFH Binding (Complement) of in body associated with age-related macular degeneration
15) Confidence 0.25 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 1.30 Pain Relevance 0
Lyme disease borreliae bind CFH, FHL1 and CFHR1 to their outer membranes through surface-exposed lipoproteins, collectively called “CRASPs” (complement regulator-acquiring surface proteins) [11], [23]–[27].
CFH Binding (bind) of associated with lyme disease
16) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 0.18 Pain Relevance 0
The various CRASPs may play similar roles, with initial interaction of the C-terminus of CFH by CRASP-3 or CRASP-5 followed by binding to internal regions SCR5 to 7 of CFH by CRASP-1 or CRASP-2.
CFH Binding (binding) of in internal
17) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 0.08 Pain Relevance 0
Based on the reactivity with the mAb VIG8 which reacts with CFH, CFHR1 and CFHR2 [41] and based on the mobility, the 43- and 37-kDa proteins correspond the two glycosylated forms CFHR1?
CFH Binding (reacts) of
18) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 0.22 Pain Relevance 0
Both CRASPs expressed on the B. garinii outer surface bound CFH as well as CFHR1 and CFHR2 in ELISA.
CFH Binding (bound) of
19) Confidence 0.25 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2958145 Disease Relevance 0.28 Pain Relevance 0
It is possible that, if strain 50/97 produced a CRASP-1 or CRASP-2 homolog, the ospE transformant would express both types of CFH-binding proteins on its surface, and thereby bind CFH at levels sufficient to prevent complement-mediated killing.
CFH Binding (bind) of associated with sprains and strains
20) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 0.84 Pain Relevance 0

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