INT4394

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Context Info
Confidence 0.50
First Reported 1975
Last Reported 1995
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.46
Pain Relevance 0.64

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intracellular (LGALS1) cytoplasm (LGALS1) signal transducer activity (LGALS1)
extracellular space (LGALS1) signal transduction (LGALS1) extracellular region (LGALS1)
Anatomy Link Frequency
myometrium 2
HbL 1
LGALS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 1 99.28 Very High Very High Very High
opiate 6 87.12 High High
antinociception 1 86.16 High High
adenocard 1 75.00 Quite High
narcan 2 59.76 Quite High
antagonist 1 59.40 Quite High
Dismenorea 4 25.00 Low Low
ischemia 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Intrahepatic Cholestasis 1 90.36 High High
Dysmenorrhea 4 76.32 Quite High
Bordatella Infection 1 66.04 Quite High
Rupture 2 60.72 Quite High
Pre-eclampsia 1 29.04 Quite Low
Cv Unclassified Under Development 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to estimate the human placental lactogen (HPL) level and its value as an indicator of fetoplacental function during labor, we determined HPL levels (N equals 225) before, during, and after labor in normal (N equals 16) and preeclamptic (N equals 14) subjects or in patients with benign intrahepatic cholestasis of pregnancy (N equals 5).
Positive_regulation (estimate) of HPL associated with intrahepatic cholestasis
1) Confidence 0.50 Published 1975 Journal Obstet Gynecol Section Abstract Doc Link 1153151 Disease Relevance 0.20 Pain Relevance 0
The increase in HbL was inhibited by morphine (2 mg kg-1, i.p.).
Positive_regulation (increase) of HbL in HbL associated with morphine
2) Confidence 0.46 Published 1994 Journal Neuroreport Section Abstract Doc Link 7881067 Disease Relevance 0 Pain Relevance 0.19
RESULTS: (1) E2, E3 levels and E2/Po, E3/Po ratio in AF, but not in serum, increased successively in the groups before labor, in normal labor and uterine inertia with significant differences (P < 0.01). (2) Both serum and AF Co, hPL concentrations were significantly different before and during labor (P < 0.01, P < 0.05). (3) Serum E2, E3, Co and hPL levels elevated significantly in cases with uterine inertia after successful treatment with estradiol benzoate or oxytocin infusion. (4) Compared with the group before labor, the amount of myometrium GJ, DB, SR increased significantly after the onset of labor.
Positive_regulation (elevated) of hPL in myometrium
3) Confidence 0.18 Published 1995 Journal Zhonghua Fu Chan Ke Za Zhi Section Body Doc Link 7587572 Disease Relevance 0.07 Pain Relevance 0
CONCLUSIONS: The elevation of serum and AF Co, hPL concentrations may be involved in the initiation of labor.
Positive_regulation (elevation) of hPL
4) Confidence 0.18 Published 1995 Journal Zhonghua Fu Chan Ke Za Zhi Section Body Doc Link 7587572 Disease Relevance 0.05 Pain Relevance 0
This hypothesis was confirmed by 1) experiments on placental membranes showing that in absence of the cytoplasmic elements (membranes only), EKC had no effect on membrane adenylate cyclase and 2) experiments on placental cells showing that dibutyryl-cAMP (dbcAMP) stimulated hPL release.
Positive_regulation (stimulated) of hPL
5) Confidence 0.08 Published 1991 Journal Life Sci. Section Abstract Doc Link 1650874 Disease Relevance 0.07 Pain Relevance 0.45
RESULTS: (1) E2, E3 levels and E2/Po, E3/Po ratio in AF, but not in serum, increased successively in the groups before labor, in normal labor and uterine inertia with significant differences (P < 0.01). (2) Both serum and AF Co, hPL concentrations were significantly different before and during labor (P < 0.01, P < 0.05). (3) Serum E2, E3, Co and hPL levels elevated significantly in cases with uterine inertia after successful treatment with estradiol benzoate or oxytocin infusion. (4) Compared with the group before labor, the amount of myometrium GJ, DB, SR increased significantly after the onset of labor.
Positive_regulation (increased) of hPL in myometrium
6) Confidence 0.08 Published 1995 Journal Zhonghua Fu Chan Ke Za Zhi Section Body Doc Link 7587572 Disease Relevance 0.08 Pain Relevance 0

General Comments

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