INT43941

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Context Info
Confidence 0.68
First Reported 1983
Last Reported 2011
Negated 0
Speculated 0
Reported most in Title
Documents 6
Total Number 6
Disease Relevance 0.78
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mme) plasma membrane (Mme)
Anatomy Link Frequency
hypothalamus 1
uterus 1
pancreas 1
striatum 1
midbrain 1
Mme (Rattus norvegicus)
Pain Link Frequency Relevance Heat
alcohol 12 99.68 Very High Very High Very High
midbrain 6 98.52 Very High Very High Very High
substance P 6 90.68 High High
opiate 3 78.72 Quite High
addiction 3 71.68 Quite High
tolerance 3 70.68 Quite High
Chronic pancreatitis 4 50.00 Quite Low
Pain 3 50.00 Quite Low
qutenza 2 48.08 Quite Low
antagonist 3 36.72 Quite Low
Disease Link Frequency Relevance Heat
Hypertension 75 99.08 Very High Very High Very High
Pancreatitis 4 75.44 Quite High
Pain 3 75.20 Quite High
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 1 5.00 Very Low Very Low Very Low
Diabetes Mellitus 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Effect of chronic alcohol consumption on activity of enkephalinase A in rat striatum, hypothalamus and midbrain].
Transcription (activity) of enkephalinase in striatum associated with midbrain and alcohol
1) Confidence 0.68 Published 1983 Journal Vopr. Med. Khim. Section Title Doc Link 6340337 Disease Relevance 0 Pain Relevance 0.41
The mRNA of neprilysin (NEP), the main enzyme involved in tachykinin metabolism, was also expressed in the uterus.
Transcription (expressed) of neprilysin in uterus
2) Confidence 0.67 Published 2003 Journal Biol. Reprod. Section Abstract Doc Link 12773411 Disease Relevance 0 Pain Relevance 0.05
[Effect of chronic alcohol consumption on activity of enkephalinase A in rat striatum, hypothalamus and midbrain].
Transcription (activity) of enkephalinase in hypothalamus associated with midbrain and alcohol
3) Confidence 0.23 Published 1983 Journal Vopr. Med. Khim. Section Title Doc Link 6340337 Disease Relevance 0 Pain Relevance 0.41
[Effect of chronic alcohol consumption on activity of enkephalinase A in rat striatum, hypothalamus and midbrain].
Transcription (activity) of enkephalinase in midbrain associated with midbrain and alcohol
4) Confidence 0.23 Published 1983 Journal Vopr. Med. Khim. Section Title Doc Link 6340337 Disease Relevance 0 Pain Relevance 0.41
The contribution of ACE, NEP, or chymase enzyme activity to the hydrolysis of 125I-Ang-(1–12) was significantly higher in SHR (ACE?
Transcription (contribution) of NEP associated with hypertension
5) Confidence 0.22 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.63 Pain Relevance 0
RESULTS: In CP tissues, NK-2R and PPT-A expression was increased, whereas NK-3R and NEP mRNA levels were comparable with normal pancreas.
Transcription (levels) of NEP in pancreas
6) Confidence 0.09 Published 2007 Journal Ann. Surg. Section Body Doc Link 17968170 Disease Relevance 0.15 Pain Relevance 0

General Comments

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