INT43944

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Context Info
Confidence 0.42
First Reported 1983
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.44
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Agt) aging (Agt) extracellular region (Agt)
extracellular matrix organization (Agt)
Anatomy Link Frequency
plasma 2
brain 2
Agt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 4 99.64 Very High Very High Very High
ischemia 7 99.44 Very High Very High Very High
Enkephalin 8 98.12 Very High Very High Very High
bradykinin 2 97.32 Very High Very High Very High
Clonidine 1 87.48 High High
noradrenaline 6 86.96 High High
Central nervous system 2 83.28 Quite High
excitatory amino acid 1 74.80 Quite High
anesthesia 1 71.56 Quite High
halothane 1 71.12 Quite High
Disease Link Frequency Relevance Heat
Hypertension 2 99.96 Very High Very High Very High
Cv General 4 Under Development 6 99.44 Very High Very High Very High
Pressure And Volume Under Development 5 93.56 High High
Stroke 3 91.64 High High
Middle Cerebral Artery Infarction 2 78.24 Quite High
Brain Hemorrhage 1 75.00 Quite High
Injury 1 75.00 Quite High
Cognitive Disorder 1 69.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ANG II-stimulated increases in plasma [AVP] and blood pressure were inhibited by 50 or 100 micrograms, respectively, of Leu-enkephalin administered into LV but not 4V.
Negative_regulation (inhibited) of Positive_regulation (increases) of ANG in plasma associated with enkephalin
1) Confidence 0.42 Published 1983 Journal Am. J. Physiol. Section Abstract Doc Link 6340533 Disease Relevance 0.08 Pain Relevance 0.71
Paralleling these effects on cerebral ischemia, olmesartan treatment also reduced the reactive upregulation in brain angiotensin II, matrix metalloproteinase-2, matrix metalloproteinase-9, and membrane type 1-matrix metalloproteinase in the ischemic area.
Negative_regulation (reduced) of Positive_regulation (upregulation) of angiotensin II in brain associated with cv general 4 under development, ischemia and metalloproteinase
2) Confidence 0.35 Published 2005 Journal Neuroscience Section Abstract Doc Link 15963646 Disease Relevance 1.12 Pain Relevance 0.57
Therefore, it can be surmised that the activation of angiotensin II AT1 receptors may reduce the transduction of the alpha 2-adrenoceptors and thus the alpha 2-mediated vasodepressor responses.
Negative_regulation (reduce) of Positive_regulation (activation) of angiotensin II
3) Confidence 0.34 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7813592 Disease Relevance 0 Pain Relevance 0.32
These drugs, widely used in the treatment of hypertension, prevent the formation of angiotensin II and the generation of free radicals, as well as the hydrolysis of bradykinin, enkephalins and endorphins.
Negative_regulation (prevent) of Positive_regulation (formation) of angiotensin II associated with hypertension, enkephalin and bradykinin
4) Confidence 0.03 Published 1996 Journal Fundam Clin Pharmacol Section Abstract Doc Link 8871140 Disease Relevance 0.24 Pain Relevance 0.34

General Comments

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