INT43948

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Context Info
Confidence 0.78
First Reported 1983
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 6.92
Pain Relevance 2.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PLA2G1B) extracellular space (PLA2G1B) extracellular region (PLA2G1B)
Anatomy Link Frequency
neutrophil leukocytes 2
monocytes 1
pancreas 1
platelets 1
PGE2 1
PLA2G1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 146 99.72 Very High Very High Very High
Chronic pancreatitis 16 98.72 Very High Very High Very High
Pain 7 98.40 Very High Very High Very High
metalloproteinase 7 98.12 Very High Very High Very High
Inflammatory response 12 82.24 Quite High
cytokine 31 78.40 Quite High
Calcitonin gene-related peptide 1 78.32 Quite High
cINOD 11 74.60 Quite High
corticosteroid 1 72.44 Quite High
aspirin 1 72.16 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 169 99.72 Very High Very High Very High
Pancreatic Cancer 6 99.60 Very High Very High Very High
Inflammatory Bowel Disease 78 99.18 Very High Very High Very High
Pancreatitis 20 98.72 Very High Very High Very High
Atherosclerosis 41 97.84 Very High Very High Very High
Pancreatic Ductal Carcinoma 6 96.68 Very High Very High Very High
Cancer 29 95.88 Very High Very High Very High
Pain 6 94.60 High High
Rheumatic Diseases 5 93.60 High High
Fat Necrosis 4 87.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phospholipase A2 was localized with peroxidase anti-peroxidase (PAP)-technique in pancreatic tissue resected from normal portions of tumor-bearing glands of 4 patients and from pancreases of 16 patients suffering from either acute or chronic pancreatitis.
Localization (localized) of Phospholipase A2 in glands associated with cancer and chronic pancreatitis
1) Confidence 0.78 Published 1983 Journal Acta Pathol Microbiol Immunol Scand A Section Abstract Doc Link 6342333 Disease Relevance 0.34 Pain Relevance 0.17
Immunohistochemical localization of phospholipase A2 in human pancreas in acute and chronic pancreatitis.
Localization (localization) of phospholipase A2 in pancreas associated with chronic pancreatitis
2) Confidence 0.78 Published 1983 Journal Acta Pathol Microbiol Immunol Scand A Section Title Doc Link 6342333 Disease Relevance 0.56 Pain Relevance 0.28
It was concluded that during acute inflammation in pancreas, localization of phospholipase A2 in pancreatic tissue is abnormal, and that phospholipases A2 of neutrophil leukocytes and platelets are not crossreactive with the secretory enzyme.
Localization (localization) of phospholipase A2 in platelets associated with inflammation
3) Confidence 0.78 Published 1983 Journal Acta Pathol Microbiol Immunol Scand A Section Abstract Doc Link 6342333 Disease Relevance 0.56 Pain Relevance 0.29
Immunohistochemical localization of group II phospholipase A2 in human pancreatic carcinomas.
Localization (localization) of II phospholipase A2 associated with pancreatic cancer
4) Confidence 0.64 Published 1993 Journal Int. J. Pancreatol. Section Title Doc Link 8384235 Disease Relevance 0.97 Pain Relevance 0.17
The immunohistochemical localization of group II phospholipase A2 (PLA2) in normal fetal and adult human pancreases, 5 chronic pancreatitis, and 30 pancreatic ductal carcinomas was investigated.
Spec (investigated) Localization (localization) of II phospholipase A2 associated with pancreatic ductal carcinoma and chronic pancreatitis
5) Confidence 0.64 Published 1993 Journal Int. J. Pancreatol. Section Abstract Doc Link 8384235 Disease Relevance 0.72 Pain Relevance 0.15
Possible role of arachidonic acid and of phospholipase A2 in the control of lysosomal enzyme release from human polymorphonuclear leukocytes.
Localization (release) of phospholipase A2 in polymorphonuclear leukocytes
6) Confidence 0.58 Published 1983 Journal J Clin Lab Immunol Section Title Doc Link 6644791 Disease Relevance 0.07 Pain Relevance 0.11
Structure-activity relationship of 2-oxoamide inhibition of group IVA cytosolic phospholipase A2 and group V secreted phospholipase A2.
Localization (secreted) of phospholipase A2 associated with inflammation
7) Confidence 0.39 Published 2007 Journal J. Med. Chem. Section Title Doc Link 17672443 Disease Relevance 0 Pain Relevance 0.30
CCA: canonical correlation analysis; FDA: Food and Drug Administration; MAF: Molecular Affinity Fingerprint; NMDA: N-methyl D-aspartate; PDB: Protein Data Bank; PCA: principal component analysis; PLA2: phospholipase A2; PP: PocketPicker; QSAR: Quantitative Structure-Activity Relationship; SAS: Statistical Analysis System for Windows; sPLA2: secretory phospholipase A2.


Localization (secretory) of phospholipase A2
8) Confidence 0.37 Published 2010 Journal BMC Struct Biol Section Body Doc Link PMC2972294 Disease Relevance 0 Pain Relevance 0.09
Structure-activity relationship of 2-oxoamide inhibition of group IVA cytosolic phospholipase A2 and group V secreted phospholipase A2.
Localization (secreted) of phospholipase A2 associated with inflammation
9) Confidence 0.34 Published 2007 Journal J. Med. Chem. Section Title Doc Link 17672443 Disease Relevance 0 Pain Relevance 0.30
It was concluded that during acute inflammation in pancreas, localization of phospholipase A2 in pancreatic tissue is abnormal, and that phospholipases A2 of neutrophil leukocytes and platelets are not crossreactive with the secretory enzyme.
Localization (localization) of phospholipase A2 in neutrophil leukocytes associated with inflammation
10) Confidence 0.27 Published 1983 Journal Acta Pathol Microbiol Immunol Scand A Section Abstract Doc Link 6342333 Disease Relevance 0.56 Pain Relevance 0.29
Relevant to the study of atherogenesis is the finding in human THP-1 monocytes that native LDL elicited a rapid, dose-dependent release of AA which was further increased when LDL was modified by secretory phospholipase A2 (PLA2) [33].
Localization (secretory) of phospholipase A2 in monocytes associated with atherosclerosis
11) Confidence 0.20 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.24 Pain Relevance 0.07
The primary pathway leading to AA release is the hydrolysis of phospholipids by enhanced activity of either secretory or cytoplasmic phospholipase A2.
Localization (secretory) of phospholipase A2
12) Confidence 0.18 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.32 Pain Relevance 0.08
Genes that were significantly up-regulated in both microarray and real-time PCR in the two IBD subtypes (compared to normal controls), include cadherin-11 (CDH11), decay accelerating factor for complement (DAF), immunoglobulin heavy constant gamma 1 (IGHG1), mucin 1 (MUC1), phospholipase A2, group IIA (PLA2G2A), and tissue inhibitor of metalloproteinase 1 (TIMP1).
Localization (include) of phospholipase A2 associated with inflammatory bowel disease and metalloproteinase
13) Confidence 0.11 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1188246 Disease Relevance 0.84 Pain Relevance 0.13
A profound cross-talk between cytosolic phospholipase A2 (cPLA2) and sPLA2-IIA with regard to free radical release has been confirmed by some investigations (Han et al 2003).
Localization (release) of phospholipase A2
14) Confidence 0.08 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515419 Disease Relevance 0.45 Pain Relevance 0.04
Design of Group IIA Secreted/Synovial Phospholipase A2 Inhibitors: An Oxadiazolone Derivative Suppresses Chondrocyte Prostaglandin E2 Secretion

Group IIA secreted/synovial phospholipase A2 (GIIAPLA2) is an enzyme involved in the synthesis of eicosanoids such as prostaglandin E2 (PGE2), the main eicosanoid contributing to pain and inflammation in rheumatic diseases.

Localization (secreted) of phospholipase A2 in PGE2 associated with pain, inflammation and rheumatic diseases
15) Confidence 0.06 Published 2010 Journal PLoS ONE Section Title Doc Link PMC2879362 Disease Relevance 0.35 Pain Relevance 0.17
 ; ITG, inferior temporal gyrus; GFAP, glial fibrillary acidic protein; ND, non-demented; PBS, phosphate-buffered saline; PCR, polymerase chain reaction; PLA2, phospholipase A2; sPLA2, secretory phospholipase A2.


Localization (secretory) of phospholipase A2 in inferior
16) Confidence 0.05 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 0.89 Pain Relevance 0.18
Among the most significant annotations (P < E-100) are for snake toxins, secreted proteins (based on annotation of signal peptides), Phospholipase A2, Knottin, protease inhibitor and defensin (ranges at E-70–E-60).
Localization (secreted) of Phospholipase A2
17) Confidence 0.05 Published 2010 Journal Bioinformatics Section Body Doc Link PMC2935411 Disease Relevance 0 Pain Relevance 0
In particular, both arachidonic acid and lysophosphatidic acid are present in microparticles previously exposed to secretory phospholipase A2 (sPLA2) [30].
Localization (secretory) of phospholipase A2
18) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174949 Disease Relevance 0.07 Pain Relevance 0.17

General Comments

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