INT4395

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Context Info
Confidence 0.50
First Reported 1975
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 6.27
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CSH1) extracellular region (CSH1)
Anatomy Link Frequency
muscle 3
plasma 1
blood 1
hepatocytes 1
Median nerve 1
CSH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcium channel 4 99.32 Very High Very High Very High
dexamethasone 2 96.48 Very High Very High Very High
carbamazepine 6 95.08 Very High Very High Very High
corticosteroid 155 92.88 High High
Migraine 1 91.00 High High
anticonvulsant 4 88.24 High High
headache 7 84.92 Quite High
withdrawal 29 84.76 Quite High
Pain 4 84.52 Quite High
Versed 2 77.12 Quite High
Disease Link Frequency Relevance Heat
Central Sleep Apnea 5 100.00 Very High Very High Very High
Airway Obstruction 2 99.88 Very High Very High Very High
Apnoea 4 99.12 Very High Very High Very High
Sleep Disorders 3 98.20 Very High Very High Very High
Sleep Apnea Syndromes 8 98.04 Very High Very High Very High
Stroke 2 93.40 High High
Nicotine Addiction 4 93.08 High High
Hypertension 20 91.56 High High
Nephrotoxicity 53 91.16 High High
Headache 8 91.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Human hepatocytes maintained in primary cultures for 72 hr in the presence of 50 microM rifampicin exhibited increased levels of P-450IIIA, determined by Western blot using specific antibodies, and concomitant increase in CsA oxidase activity, determined by HPLC analysis of extra and intracellular media.
Positive_regulation (increase) of CsA in hepatocytes
1) Confidence 0.50 Published 1990 Journal Drug Metab. Dispos. Section Abstract Doc Link 1981707 Disease Relevance 0 Pain Relevance 0
In order to estimate the human placental lactogen (HPL) level and its value as an indicator of fetoplacental function during labor, we determined HPL levels (N equals 225) before, during, and after labor in normal (N equals 16) and preeclamptic (N equals 14) subjects or in patients with benign intrahepatic cholestasis of pregnancy (N equals 5).
Positive_regulation (estimate) of placental lactogen associated with intrahepatic cholestasis
2) Confidence 0.41 Published 1975 Journal Obstet Gynecol Section Abstract Doc Link 1153151 Disease Relevance 0.15 Pain Relevance 0
Drugs detected as potential inducers of CsA oxidase included: rifampicin, sulfadimidine, phenobarbital, phenytoin, phenylbutazone, dexamethasone, sulfinpyrazone, and carbamazepine.
Positive_regulation (inducers) of CsA associated with dexamethasone and carbamazepine
3) Confidence 0.36 Published 1990 Journal Drug Metab. Dispos. Section Abstract Doc Link 1981707 Disease Relevance 0 Pain Relevance 0.17
The lack of identifiable risk factors place those who undergo CSMT at risk of neurologic damage.
Positive_regulation (undergo) of CSMT
4) Confidence 0.35 Published 2007 Journal South. Med. J. Section Abstract Doc Link 17330693 Disease Relevance 1.46 Pain Relevance 0.43
OSA results from upper airway obstruction, and CSA is due to lack of inspiratory muscle effort; mixed apnea results from a combination of these factors.
Positive_regulation (due) of CSA in muscle associated with apnoea, central sleep apnea, airway obstruction and sleep disorders
5) Confidence 0.29 Published 2004 Journal Semin Neurol Section Abstract Doc Link 15449219 Disease Relevance 1.91 Pain Relevance 0.08
The asymmetry where increasing qsR1,Calf did not elevate [sR1]IS,Normal was due to the fact that the intravasation flow of the complex from the calf was insufficient to elevate [sR1]pl on its own.
Positive_regulation (elevate) of pl
6) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
The cycle completes with part of the elevated [sR1]pl extravasating back into the interstitium, hence accounting for the increase in [sR1]IS,Calf in the direction of increasing qsR1,Normal.
Positive_regulation (elevated) of pl
7) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
Although the control secretion rates needed to reach a target set of [V]pl and [sR1]pl were not unique – i.e., higher sVEGFR1-secretion rates could theoretically also have elevated [V]pl from below 1 pM in absence of sVEGFR1 to 1.5 pM in presence of sVEGFR1 – we settled on this set of qV,+Ctrl and qsR1,Ctrl (Table 11) such that [V]pl remained within experimental range, with or without sVEGFR1 expression in the simulation.

1.2.

Positive_regulation (elevated) of pl
8) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
The control sVEGFR1-secretion rates that could attain a [sR1]pl of 100 pM, as well as symmetric [sR1]IS (i.e, 36 pM in both “calf” and “normal” interstitia), were determined to be qsR1,Ctrl?
Positive_regulation (attain) of pl
9) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
Immediately after the onset of exercise, independent simulation of activity-dependent kL predicted that an elevation in [V]pl preceded the larger but slower elevation in [sR1]pl (Fig. 9B).
Positive_regulation (elevation) of pl
10) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0.06 Pain Relevance 0
50% elevation in [sR1]pl (peaking ?
Positive_regulation (elevation) of pl
11) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0.07 Pain Relevance 0
Immediately after the onset of exercise, independent simulation of activity-dependent kL predicted that an elevation in [V]pl preceded the larger but slower elevation in [sR1]pl (Fig. 9B).
Positive_regulation (elevation) of pl
12) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0.06 Pain Relevance 0
Men and women showed significant and nearly identical decreases in total muscle CSA after 14 D of immobilization (men?
Positive_regulation (muscle) of CSA in muscle
13) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0 Pain Relevance 0
Grapefruit and grapefruit juice also increase blood concentrations of Csa and should be avoided.
Positive_regulation (increase) of Csa in blood
14) Confidence 0.09 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.28 Pain Relevance 0.12
Antithymocyte globulin was given for induction and MMF/CSA were given as maintenance regimen.
Positive_regulation (induction) of CSA
15) Confidence 0.08 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697521 Disease Relevance 0.05 Pain Relevance 0.23
Increases of 3–9% in muscle CSA, doubling of muscle strength, and improvement in functional performance indices have been reported in nursing home populations after bouts of progressive resistance training [93, 94].
Positive_regulation (Increases) of CSA in muscle
16) Confidence 0.07 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2832869 Disease Relevance 0.18 Pain Relevance 0
Examples of some common medications which inhibit the P450 pathway and therefore increase Csa levels include: calcium channel blockers (diltiazem, verapamil, nicardipine); antibiotics (erythomycin, azithromycin, clarithromycin,quinopristin/daltopristin); antifungals (fluconazole, itraconazole, ketoconazole); amiodarone; allopurinol; bromocriptine; colchicines and metoclopramide.
Positive_regulation (increase) of Csa associated with calcium channel
17) Confidence 0.07 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.79 Pain Relevance 0.05
Protease inhibitors used for treating human immunodeficieny virus (e.g., indinavir, nelfinavir, ritonavir, and saquinavir) are known to inhibit cytochrome P-450 3A and thus could potentially increase the concentrations of Csa.
Positive_regulation (increase) of Csa
18) Confidence 0.07 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.59 Pain Relevance 0.11
Csa increases the plasma concentration of prednisolone while high doses of methylprednisolone increase plasma concentrations of Csa.

6.5.

Positive_regulation (increase) of Csa in plasma
19) Confidence 0.07 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.20 Pain Relevance 0.33
The concentration of CSA was increased to 10% by the second treatment.
Positive_regulation (increased) of CSA
20) Confidence 0.06 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2946856 Disease Relevance 0.47 Pain Relevance 0

General Comments

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