INT43958

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Context Info
Confidence 0.52
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.54
Pain Relevance 2.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Zbp1) nucleus (Zbp1) DNA binding (Zbp1)
biological_process (Zbp1) cytoplasm (Zbp1)
Anatomy Link Frequency
caudate nucleus 3
Zbp1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 9 99.00 Very High Very High Very High
dopamine receptor 3 91.64 High High
Inflammation 49 91.28 High High
antagonist 3 85.76 High High
Morphine 9 82.04 Quite High
Dopamine 6 75.00 Quite High
depression 4 65.84 Quite High
cytokine 41 58.00 Quite High
Paracetamol 122 54.84 Quite High
chemokine 34 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 75 91.28 High High
Volume Depletion And Dehydration 2 78.00 Quite High
Pressure And Volume Under Development 8 77.04 Quite High
Lung Injury 12 66.96 Quite High
Depression 4 65.84 Quite High
Adult Respiratory Distress Syndrome 46 50.00 Quite Low
Pneumonia 18 47.60 Quite Low
Injury 17 28.36 Quite Low
Hepatotoxicity 17 5.00 Very Low Very Low Very Low
Necrosis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Zbp1 activation of IRF3 is dependent on the recruitment of TBK-1 (TANK-binding kinase-1) and an I?
Positive_regulation (activation) of Zbp1
1) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882945 Disease Relevance 0.07 Pain Relevance 0.14
Simultaneous activation of the DAi receptors within the septum and those within the caudate nucleus produced an effect characteristics of activation of septal DAi receptors; the effect characteristic of activation of caudate DAi receptors was suppressed.
Positive_regulation (activation) of DAi in caudate nucleus
2) Confidence 0.50 Published 1983 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 6344105 Disease Relevance 0 Pain Relevance 0.52
Simultaneous activation of the DAi receptors within the septum and those within the caudate nucleus produced an effect characteristics of activation of septal DAi receptors; the effect characteristic of activation of caudate DAi receptors was suppressed.
Positive_regulation (activation) of DAi in caudate nucleus
3) Confidence 0.44 Published 1983 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 6344105 Disease Relevance 0 Pain Relevance 0.51
Simultaneous activation of the DAi receptors within the septum and those within the caudate nucleus produced an effect characteristics of activation of septal DAi receptors; the effect characteristic of activation of caudate DAi receptors was suppressed.
Positive_regulation (activation) of DAi in caudate nucleus
4) Confidence 0.32 Published 1983 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 6344105 Disease Relevance 0 Pain Relevance 0.50
In addition, DAI-1, previously named DLM-1 or Z-DNA binding protein 1, has been identified as a cytoplasmic receptor that senses and is activated by DNA, leading to type I IFN gene induction [31].
Positive_regulation (activated) of DAI-1
5) Confidence 0.14 Published 2009 Journal Respir Res Section Body Doc Link PMC2761862 Disease Relevance 0.74 Pain Relevance 0.31
In addition, DAI-1, previously named DLM-1 or Z-DNA binding protein 1, has been identified as a cytoplasmic receptor that senses and is activated by DNA, leading to type I IFN gene induction [31].
Positive_regulation (activated) of Z-DNA binding protein 1
6) Confidence 0.14 Published 2009 Journal Respir Res Section Body Doc Link PMC2761862 Disease Relevance 0.74 Pain Relevance 0.31

General Comments

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