INT43984

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Context Info
Confidence 0.49
First Reported 1983
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 6.30
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (LPA) transport (LPA) small molecule metabolic process (LPA)
extracellular region (LPA) lipid metabolic process (LPA)
Anatomy Link Frequency
blood 2
plasma 2
neural tube 2
LPA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 10 97.20 Very High Very High Very High
tolerance 1 94.80 High High
Arthritis 1 94.72 High High
Multiple sclerosis 2 94.12 High High
Angina 7 85.04 High High
cytokine 1 81.20 Quite High
imagery 11 65.36 Quite High
agonist 14 59.76 Quite High
Opioid 10 50.00 Quite Low
Bioavailability 1 44.96 Quite Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 8 100.00 Very High Very High Very High
Sleep Disorders 36 99.96 Very High Very High Very High
Exencephaly /

Neural Tube Defects

3 97.88 Very High Very High Very High
Thrombosis 5 97.32 Very High Very High Very High
INFLAMMATION 11 97.20 Very High Very High Very High
Adult Respiratory Distress Syndrome 118 96.20 Very High Very High Very High
Apoptosis 4 95.28 Very High Very High Very High
Cancer 10 95.04 Very High Very High Very High
Impaired Glucose Tolerance 1 94.80 High High
Arthritis 1 94.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hence, anti-thrombotic therapy targeting LPA production or receptor-mediated signaling may be a novel strategy to prevent thrombus formation.
Regulation (targeting) of Gene_expression (production) of LPA associated with thrombosis
1) Confidence 0.49 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996775 Disease Relevance 1.33 Pain Relevance 0.06
CONCLUSIONS: With the cautions due to the cross-sectional design of the study and the limited statistical power, these results suggest a possible synergistic effect between elevated Lp(a) levels and other pro-atherogenic factors such as smoking on the risk of vascular diseases in older individuals.


Spec (possible) Regulation (effect) of Gene_expression (levels) of Lp
2) Confidence 0.42 Published 2001 Journal J Am Geriatr Soc Section Body Doc Link 11207864 Disease Relevance 0 Pain Relevance 0
Autotaxin is the enzyme responsible for the production of lysophosphatidic acid (LPA) from lysophosphatidyl choline (LPC), and it is up-regulated in many inflammatory conditions, including but not limited to cancer, arthritis, and multiple sclerosis.
Regulation (responsible) of Gene_expression (production) of LPA associated with multiple sclerosis, inflammation, cancer and arthritis
3) Confidence 0.38 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20392816 Disease Relevance 0.61 Pain Relevance 0.26
Similarly, genetic deletion of Autotaxin, the enzyme responsible for production of LPA in the brain, yields embryonically lethal mice with neural tube defects.
Regulation (responsible) of Gene_expression (production) of LPA in neural tube
4) Confidence 0.14 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2621239 Disease Relevance 0.41 Pain Relevance 0
Pioglitazone did not significantly change apolipoprotein B levels but did reduce LDL particle concentration.
Neg (not) Regulation (change) of Gene_expression (levels) of apolipoprotein B associated with disorder of lipid metabolism
5) Confidence 0.11 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686257 Disease Relevance 0.64 Pain Relevance 0.03
First, we wondered whether the adoption of LP MV would affect sedation requirements in our ICU, where a strict sedation protocol is applied that is aimed at achieving the lowest possible level of sedation [10,11].
Spec (whether) Regulation (affect) of Gene_expression (adoption) of LP MV associated with sleep disorders
6) Confidence 0.05 Published 2007 Journal Crit Care Section Body Doc Link PMC2206517 Disease Relevance 2.38 Pain Relevance 0
METHODS: From patients with chest pain; venous blood samples were collected for measuring serum Lp(a) and C-reactive protein (CRP) levels on admission and serum cTn-I levels 12 and 24 hours after admission.
Regulation (measuring) of Gene_expression (levels) of Lp in blood
7) Confidence 0.04 Published 2006 Journal Anadolu Kardiyol Derg Section Body Doc Link 16524794 Disease Relevance 0 Pain Relevance 0
There was a decrease in plasma triglyceride and low-density lipoprotein (LDL) cholesterol levels, but no change in high-density lipoprotein (HDL) cholesterol, apolipoprotein AI and B concentrations.
Neg (no) Regulation (change) of Gene_expression (concentrations) of apolipoprotein AI in plasma associated with disorder of lipid metabolism
8) Confidence 0.03 Published 1983 Journal Arch Phys Med Rehabil Section Abstract Doc Link 6351804 Disease Relevance 0.52 Pain Relevance 0.26
For this reason studying the interaction of enzyme with substrate is paramount to understanding the regulation of LPA production.


Regulation (regulation) of Gene_expression (production) of LPA
9) Confidence 0.02 Published 2009 Journal Lipids Health Dis Section Abstract Doc Link PMC2649126 Disease Relevance 0.15 Pain Relevance 0

General Comments

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