INT43985

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Context Info
Confidence 0.62
First Reported 1983
Last Reported 2010
Negated 4
Speculated 7
Reported most in Body
Documents 29
Total Number 37
Disease Relevance 20.79
Pain Relevance 3.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (LPA) transport (LPA) small molecule metabolic process (LPA)
extracellular region (LPA) lipid metabolic process (LPA)
Anatomy Link Frequency
plasma 6
blood 5
heart 2
neural 2
body 2
LPA (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 44 98.98 Very High Very High Very High
Angina 67 98.68 Very High Very High Very High
nud 4 98.20 Very High Very High Very High
Hyperalgesia 1 98.16 Very High Very High Very High
tolerance 4 94.80 High High
antagonist 3 94.40 High High
Migraine 7 94.04 High High
ischemia 3 93.96 High High
agonist 62 93.12 High High
Multiple sclerosis 82 92.76 High High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 281 100.00 Very High Very High Very High
Cardiovascular Disease 155 100.00 Very High Very High Very High
Sprains And Strains 3 100.00 Very High Very High Very High
Stress 17 99.84 Very High Very High Very High
Birth Weight 109 99.62 Very High Very High Very High
Brain Hemorrhage 257 99.46 Very High Very High Very High
Obesity 78 99.44 Very High Very High Very High
Hyperhomocysteinemia 8 99.28 Very High Very High Very High
Coronary Artery Disease 183 99.20 Very High Very High Very High
Cv General 3 Under Development 69 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Basically, Lp(a) is not easily modified by statin therapy.14) Although there are contradictory findings about the effect of statins on Lp(a) serum concentrations,15) it is uncertain whether statin use prevents the coronary heart disease associated with Lp(a).16) Nearly 80% of patients in our study were administered statins, and since the numbers of patients taking statins were almost equally distributed among the tertiles, statin therapy probably did not influence our results.
Regulation (effect) of Lp in heart associated with coronary artery disease
1) Confidence 0.62 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978291 Disease Relevance 0.68 Pain Relevance 0.05
Because, body weight, family history, socio-economic factors including income, gender, ethnicity, birth weight and regional diversity have been shown to influence levels of Lp(a) and or CVD risk in general, [18,6,21] our analyses of the population estimate and correlates of Lp(a) were mindful of these factors.
Regulation (influence) of Lp in body associated with birth weight, body weight and cardiovascular disease
2) Confidence 0.59 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC544891 Disease Relevance 0.37 Pain Relevance 0
In any case, it has been recently shown that the contribution of the apo(a) isoform size to the control of plasma Lp(a) level is considerably lower than previously calculated, because the variability in plasma Lp(a) concentration is not uniform across the apo(a) size spectrum [17].


Regulation (control) of Lp in plasma
3) Confidence 0.50 Published 2003 Journal BMC Cardiovasc Disord Section Body Doc Link PMC327094 Disease Relevance 1.24 Pain Relevance 0
By analyzing Lp(a) concentrations according to sex, we observed a significant difference in Lp(a) 300 mg/L cutoff value between patients and controls in the female (P = 0.002) but not in the male group.
Spec (analyzing) Regulation (analyzing) of Lp
4) Confidence 0.38 Published 2009 Journal Transl Res Section Abstract Doc Link 19100957 Disease Relevance 0.79 Pain Relevance 0.49
In additional, some other serum markers such as homocysteine (Hcy) or brain natriuretic peptide (BNP), known to correlate with an increased incidence of SBI, might be involved in the alteration of LPA levels.
Regulation (alteration) of LPA in brain associated with brain hemorrhage and natriuresis
5) Confidence 0.36 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996775 Disease Relevance 1.11 Pain Relevance 0
This study aimed at evaluating the influence of 3 probiotic strains: Bifidobacterium lactis NCC362, Lactobacillus johnsonii NCC533, and Lpa on stress-mediated alterations of colorectal hyperalgesia, on gut paracellular permeability and whether bacteria and/or bacterial products present in the spent culture medium (SCM) were involved in the antinociceptive properties of the effective strain.
Spec (whether) Regulation (influence) of Lpa in gut associated with stress, hyperalgesia, sprains and strains and antinociceptive
6) Confidence 0.33 Published 2007 Journal J. Nutr. Section Abstract Doc Link 17634262 Disease Relevance 0.61 Pain Relevance 0.19
To study the effects of pharmacological inhibitors on LPA and S1P stimulated changes in morphology, hES-NEP cells were plated in 6-well plates.
Regulation (effects) of LPA
7) Confidence 0.32 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2621239 Disease Relevance 0 Pain Relevance 0
While the current study describes LPA and S1P effects on proliferation and morphological changes, hES-NEPs are also a promising model cell system in which to study LPA and S1P effects in multiple processes of neural development.
Regulation (effects) of LPA in neural
8) Confidence 0.32 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2621239 Disease Relevance 0 Pain Relevance 0
Last, hormone replacement therapy (HRT) in female patients, which can affect serum Lp(a) levels, was not considered in this study.
Regulation (affect) of Lp
9) Confidence 0.27 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978291 Disease Relevance 0.46 Pain Relevance 0
As discussed above, there are clear roles for S1P and LPA in early neural tube development.
Spec (clear) Regulation (roles) of LPA in neural tube
10) Confidence 0.27 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2621239 Disease Relevance 0.37 Pain Relevance 0
We utilized data from a national survey of over 30,000 persons age 1 year and older with extensive blood lipid data to examine correlates of Lp(a) in children and adolescents and specifically to determine whether: [1] ethnic differences in shape of Lp(a) distributions seen in adults are also seen as early as age 4 in children; [2] family history of cardiovascular disease is associated with higher levels of Lp(a); [3] the effects of ethnicity and family history of CVD on the levels of Lp(a) are influenced by low birth weight, other personal, behavioral or environmental variables.


Regulation (effects) of Lp in blood associated with birth weight and cardiovascular disease
11) Confidence 0.26 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC544891 Disease Relevance 0.42 Pain Relevance 0
It therefore appears likely, that multiple factors at the environment and or genetic levels may act together to differentially influence levels of Lp(a) in children and adolescents in the US.


Regulation (influence) of Lp
12) Confidence 0.26 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC544891 Disease Relevance 0.28 Pain Relevance 0.08
Despite the levels of Lp(a) that tended to be highest between age 6 – 11 years in boys, the lack of similar trend in girls, and the absence of age-related difference in the levels of Lp(a) in the combined group, suggests that pre-pubertal or pubertal status may not significantly influence levels of Lp(a) in children.
Regulation (influence) of Lp
13) Confidence 0.26 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC544891 Disease Relevance 0.10 Pain Relevance 0.05
The quality control of the Lp(a) assay has been described in detail elsewhere [14].
Regulation (control) of Lp
14) Confidence 0.26 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC544891 Disease Relevance 0.82 Pain Relevance 0.07
Because birth weight has been shown to influence levels of Lp(a) [6], and adverse patterns of blood lipids and atherosclerosis itself begin in childhood, studies of population and individual differences in the early onset and progression of risk factors through adolescence are important [7].
Regulation (influence) of Lp in blood associated with birth weight and atherosclerosis
15) Confidence 0.26 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC544891 Disease Relevance 0.99 Pain Relevance 0
Thus, LPA is now one of the most attractive targets for prevention and treatment of various diseases.
Regulation (targets) of LPA associated with disease
16) Confidence 0.23 Published 2008 Journal Curr. Med. Chem. Section Abstract Doc Link 18781939 Disease Relevance 0.46 Pain Relevance 0.18
While the current study describes LPA and S1P effects on proliferation and morphological changes, hES-NEPs are also a promising model cell system in which to study LPA and S1P effects in multiple processes of neural development.
Regulation (effects) of LPA in neural
17) Confidence 0.23 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2621239 Disease Relevance 0 Pain Relevance 0
The median of Lp(a) level was 14.1 mg/dl (the 25th percentile was 6.2 mg/dl and the 75th percentile was 26.7 mg/dl). 2) The values of serum Lp(a) in subjects with vasospastic angina distributed at a higher level than for subjects with normal coronary arteries as diagnosed by coronary angiography. 3) The observed serum Lp(a) concentration moved to a higher range as the number of branches with significant stenosis on the coronary angiography increased. 4) Serum Lp(a) was one of the risk factors for ischemic heart disease.
Regulation (values) of Lp in heart associated with angina, coronary artery disease and pathologic constriction
18) Confidence 0.22 Published 1993 Journal Hiroshima J. Med. Sci. Section Abstract Doc Link 8253601 Disease Relevance 0.27 Pain Relevance 0.10
The cut-off values for LPA levels were classified according to the degree of platelet activation in this study as follows: If the LPA concentration ?
Regulation (values) of LPA in platelet
19) Confidence 0.22 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996775 Disease Relevance 0 Pain Relevance 0
Future studies, therefore, need to include not only prospective or longitudinal LPA comparative analyses but also investigations that will determine whether plasma LPA levels are influenced by other medical conditions or biomarkers which affecting the production, secretion and circulation of LPA.
Spec (whether) Regulation (affecting) of LPA in plasma
20) Confidence 0.22 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996775 Disease Relevance 1.33 Pain Relevance 0.04

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