INT43997

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Context Info
Confidence 0.51
First Reported 1983
Last Reported 2011
Negated 0
Speculated 3
Reported most in Body
Documents 57
Total Number 60
Disease Relevance 36.66
Pain Relevance 5.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Esr1) DNA binding (Esr1) protein complex (Esr1)
cytoplasm (Esr1) lipid binding (Esr1) nucleus (Esr1)
Anatomy Link Frequency
apoptotic cell 6
epithelium 6
3T3-L1 6
erythrocyte 4
neuronal 4
Esr1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 112 100.00 Very High Very High Very High
Arthritis 177 99.84 Very High Very High Very High
backache 12 99.64 Very High Very High Very High
spinal inflammation 9 99.64 Very High Very High Very High
Crohn's disease 153 99.24 Very High Very High Very High
agonist 219 99.10 Very High Very High Very High
ischemia 203 98.80 Very High Very High Very High
Inflammation 327 98.60 Very High Very High Very High
rheumatoid arthritis 62 98.48 Very High Very High Very High
Chronic low back pain 13 97.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 543 100.00 Very High Very High Very High
Bacteremia 1 100.00 Very High Very High Very High
Hypoxia 149 99.98 Very High Very High Very High
Seronegative Spondarthritis 5 99.84 Very High Very High Very High
Targeted Disruption 154 99.78 Very High Very High Very High
Multiple Sclerosis 235 99.70 Very High Very High Very High
Low Back Pain 34 99.64 Very High Very High Very High
Death 289 99.62 Very High Very High Very High
Repression 14 99.60 Very High Very High Very High
Injury 198 99.46 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The higher responsiveness of BALB/c mice was associated with higher levels of expression of ER-?
Positive_regulation (levels) of Gene_expression (expression) of ER
1) Confidence 0.51 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.81 Pain Relevance 0
agonist displaying a more than 484-fold selectivity over ER?
Positive_regulation (over) of Gene_expression (over) of ER associated with agonist
2) Confidence 0.47 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.42 Pain Relevance 0.46
In the evaluation of our patient, four items were of particular importance: awareness of his previously documented S. aureus bacteremia, a markedly elevated ESR, an abnormal chest radiograph, and the positive bone scan.
Positive_regulation (elevated) of Gene_expression (awareness) of ESR in chest associated with bacteremia
3) Confidence 0.43 Published 1996 Journal Dig. Dis. Sci. Section Abstract Doc Link 8689935 Disease Relevance 0.61 Pain Relevance 0.17
In addition, virgin BALB/c mammary glands expressed higher levels of PR-A and ER-?
Positive_regulation (levels) of Gene_expression (expressed) of ER in mammary glands
4) Confidence 0.42 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.35 Pain Relevance 0
In the present study we thus chose a dose of 3 mg/kg subcutaneous yielding plasma level concentrations (around 1 × 10-8 M) adequate for engaging ER?
Positive_regulation (adequate) of Gene_expression (engaging) of ER in plasma
5) Confidence 0.41 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.26 Pain Relevance 0.27
Overexpression of the ER?
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of ER
6) Confidence 0.41 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0 Pain Relevance 0
Overexpression of this truncated form of ER?
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of ER
7) Confidence 0.41 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0 Pain Relevance 0.03
are expressed in both the immune system and the CNS [188,189,194,195], oestrogen receptor knock out mice have been used to show that the protective effect of oestrogen treatment (oestradiol and oestriol) in EAE was dependent upon the presence of ER?
Positive_regulation (upon) of Gene_expression (presence) of ER in immune system associated with targeted disruption, multiple sclerosis and central nervous system
8) Confidence 0.41 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 0.41 Pain Relevance 0.07
It is concluded that a persistent moderate elevation in ESR detected in a young adult in the course of screening examinations is a risk factor for the development of disease.
Spec (examinations) Positive_regulation (elevation) of Gene_expression (detected) of ESR associated with disease
9) Confidence 0.40 Published 1984 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 6465082 Disease Relevance 0.62 Pain Relevance 0.17
Interestingly, we also observed ER?
Positive_regulation (observed) of Gene_expression (observed) of ER
10) Confidence 0.39 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254628 Disease Relevance 0 Pain Relevance 0
As proof of principle, Frech and coworkers [58] developed transgenic mice that overexpress ER-?
Positive_regulation (overexpress) of Gene_expression (overexpress) of ER associated with targeted disruption
11) Confidence 0.34 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.52 Pain Relevance 0
We were unable to confirm using immunohistochemistry whether ER?
Spec (whether) Positive_regulation (using) of Gene_expression (using) of ER
12) Confidence 0.34 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254628 Disease Relevance 0 Pain Relevance 0
10 cm plates and transfected with increasing amount of ER?
Positive_regulation (increasing) of Gene_expression (amount) of ER
13) Confidence 0.34 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0 Pain Relevance 0.03
Overexpression of ER?
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of ER
14) Confidence 0.34 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0 Pain Relevance 0
To assure adequate overexpression and function of ER?
Positive_regulation (overexpression) of Gene_expression (overexpression) of ER
15) Confidence 0.34 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0 Pain Relevance 0
activity through ER?
Positive_regulation (activity) of Gene_expression (through) of ER
16) Confidence 0.34 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.17 Pain Relevance 0.03
Our in-vitro experiments in 3T3-L1 preadipocytes showed that ER?
Positive_regulation (experiments) of Gene_expression (showed) of ER in 3T3-L1
17) Confidence 0.34 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.18 Pain Relevance 0
Overexpression of ER?
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of ER
18) Confidence 0.34 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.11 Pain Relevance 0.04
To characterize the metabolic function of ER?
Positive_regulation (function) of Gene_expression (function) of ER
19) Confidence 0.34 Published 2008 Journal PLoS Genetics Section Abstract Doc Link PMC2432036 Disease Relevance 0.47 Pain Relevance 0
In consonance, we could recently demonstrate that ER?
Positive_regulation (demonstrate) of Gene_expression (demonstrate) of ER
20) Confidence 0.34 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.23 Pain Relevance 0.05

General Comments

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