INT44

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Context Info
Confidence 0.68
First Reported 1976
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 30
Total Number 31
Disease Relevance 7.09
Pain Relevance 12.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra1a) aging (Adra1a) plasma membrane (Adra1a)
response to stress (Adra1a) signal transducer activity (Adra1a)
Anatomy Link Frequency
nerve 3
heart 2
plasma 1
macrophage 1
pulmonary artery 1
Adra1a (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 45 100.00 Very High Very High Very High
antagonist 31 100.00 Very High Very High Very High
Neurotransmitter 4 99.98 Very High Very High Very High
Opioid 6 99.90 Very High Very High Very High
Neuropeptide 5 99.80 Very High Very High Very High
Clonidine 49 99.60 Very High Very High Very High
Angina 6 99.48 Very High Very High Very High
Rsd 5 99.44 Very High Very High Very High
Calcium channel 3 99.42 Very High Very High Very High
noradrenaline 19 98.94 Very High Very High Very High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 4 99.58 Very High Very High Very High
Angina 6 99.48 Very High Very High Very High
Reflex Sympathetic Dystrophy 5 99.44 Very High Very High Very High
Obesity 7 98.88 Very High Very High Very High
Hyperphagia 1 98.88 Very High Very High Very High
Pain 8 98.36 Very High Very High Very High
Injury 1 98.36 Very High Very High Very High
Cancer 6 98.12 Very High Very High Very High
Necrosis 2 97.88 Very High Very High Very High
Coronary Artery Disease 3 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Progress has been made in understanding RSDS, with the demonstration of increased alpha-adrenergic receptor activity in peripheral nerves following injury.
Positive_regulation (increased) of alpha-adrenergic receptor in peripheral nerves associated with rsd and injury
1) Confidence 0.68 Published 1994 Journal Curr Opin Rheumatol Section Abstract Doc Link 8024969 Disease Relevance 0.54 Pain Relevance 0.66
The noradrenaline evoked increase in input resistance was mediated by activation of an alpha 1 receptor site.
Positive_regulation (activation) of alpha 1 receptor site associated with noradrenaline
2) Confidence 0.58 Published 1988 Journal Neuroscience Section Abstract Doc Link 2452379 Disease Relevance 0 Pain Relevance 0.65
The results of these experiments suggest that the changes in glutathione homeostasis produced by alpha-adrenoreceptor stimulation may be sufficient to impair detoxification mechanisms.
Positive_regulation (stimulation) of alpha-adrenoreceptor
3) Confidence 0.50 Published 1991 Journal Toxicology Section Abstract Doc Link 1683031 Disease Relevance 0.29 Pain Relevance 0.68
Medical expulsion therapy with alpha-adrenoceptor antagonists or calcium channel antagonists is efficacious. alpha-Adrenoceptor antagonists such as the alpha(1A/)(1)(D)-selective tamsulosin are well tolerated in the elderly and increase the rate of spontaneous stone passage by approximately 50% for small distal stones.
Positive_regulation (increase) of alpha-Adrenoceptor associated with calcium channel and antagonist
4) Confidence 0.48 Published 2007 Journal Drugs Aging Section Abstract Doc Link 17953457 Disease Relevance 0.68 Pain Relevance 1.26
The result suggests that high doses of clonidine elicit jumping in which alpha-adrenoceptor activation, dopaminergic and cholinergic inhibition are concomitantly involved.
Positive_regulation (activation) of alpha-adrenoceptor associated with clonidine
5) Confidence 0.47 Published 1984 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 6505377 Disease Relevance 0 Pain Relevance 0.44
Desensitization of alpha 1 adrenergic receptor induced by continuous high plasma norepinephrine concentration, was considered to decrease vascular resistance.
Positive_regulation (induced) of alpha 1 adrenergic receptor in plasma
6) Confidence 0.46 Published 1994 Journal Masui Section Abstract Doc Link 8189622 Disease Relevance 0.70 Pain Relevance 0.09
The alpha-2-adrenoceptor agonist, clonidine, had no effect on islet blood flow, suggesting that the effect of norepinephrine was due to alpha-1-adrenoceptor stimulation.
Positive_regulation (stimulation) of alpha-1-adrenoceptor in blood associated with agonist and clonidine
7) Confidence 0.45 Published 1985 Journal Microvasc. Res. Section Abstract Doc Link 3900643 Disease Relevance 0.32 Pain Relevance 0.15
Each of these pain states has been associated with abnormal sympathetic nervous system function and increased peripheral alpha-1 adrenoceptor activity.
Positive_regulation (increased) of alpha-1 adrenoceptor in sympathetic nervous system associated with pain
8) Confidence 0.38 Published 2004 Journal Pain Res Manag Section Abstract Doc Link 15211988 Disease Relevance 1.69 Pain Relevance 1.17
However, the effects of alpha-adrenoceptor activation on cerebellar inhibitory neurotransmission have not yet been fully elucidated.
Positive_regulation (activation) of alpha-adrenoceptor
9) Confidence 0.37 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16251261 Disease Relevance 0 Pain Relevance 0.29
It is concluded, that under in vivo conditions in the mouse, alpha 1-adrenoceptor activation stimulates basal thyroid hormone secretion and inhibits TSH-induced thyroid hormone secretion.
Positive_regulation (activation) of alpha 1-adrenoceptor in thyroid
10) Confidence 0.35 Published 1985 Journal Acta Endocrinol. Section Abstract Doc Link 2857513 Disease Relevance 0 Pain Relevance 0.66
The present study was aimed at determining whether repeated MIR treatment induced adaptive changes in the alpha1-adrenergic receptors, similar to those reported by us early for tricyclic antidepressants, The experiments were carried out on male mice and rats.
Spec (whether) Positive_regulation (induced) of alpha1-adrenergic associated with tricyclic antidepressant
11) Confidence 0.35 Published 2002 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 11939713 Disease Relevance 0.14 Pain Relevance 0.28
Multiple behavioral and neurochemical abnormalities are found in the genetically obese mouse, obob , including hyperphagia, elevated hypothalamic norepinephrine (NE) levels, and increases alpha-1 receptor density.
Positive_regulation (increases) of alpha-1 receptor associated with hyperphagia, congenital anomalies and obesity
12) Confidence 0.35 Published 1984 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 6145164 Disease Relevance 0.60 Pain Relevance 0
Increased reactivity of murine mesenteric veins to adrenergic agonists: functional evidence supporting increased alpha1-adrenoceptor reserve in veins compared with arteries.
Positive_regulation (increased) of alpha1-adrenoceptor in veins associated with agonist
13) Confidence 0.33 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 14593081 Disease Relevance 0.09 Pain Relevance 0.17
The patients with variant angina had significantly higher capacity of platelet alpha-adrenoceptor than controls (49% increase) or patients with other types of ischemic heart disease.
Positive_regulation (capacity) of platelet alpha-adrenoceptor in heart associated with angina and coronary artery disease
14) Confidence 0.22 Published 1989 Journal Thromb. Res. Section Abstract Doc Link 2575802 Disease Relevance 0.83 Pain Relevance 0.59
To establish the subtype of alpha adrenergic receptor mediating the action of xylazine, goats were pretreated with either prazosin (1.0 mg/kg, i.v.) or yohimbine (1.0 micrograms/kg, i.v.).
Positive_regulation (mediating) of alpha adrenergic receptor
15) Confidence 0.19 Published 1994 Journal J. Vet. Pharmacol. Ther. Section Abstract Doc Link 7910855 Disease Relevance 0.08 Pain Relevance 0.20
1 The effects of several drugs upon the excitatory junction potential (e.j.p.) in the guinea-pig vas deferens have been investigated. 2 Amiodarone, a noradrenergic neurone blocker which also blocks both alpha and beta-adrenoreceptors, did not reduce the e.j.p. 3 The alpha-adrenoreceptor antagonists, azapetine, piperoxan and prazosin, only enhanced the e.j.p. irrespective of their relative potencies at alpha 1 and alpha 2-adrenoreceptors. 4 Sotalol, a beta-adrenoreceptor antagonist, was without effect upon the e.j.p. 5 Clonidine and lysergic acid diethylamide, alpha-adrenoreceptor agonists, produced a dose dependent inhibition of the e.j.p. without apparently affecting the frequency or size of spontaneous junction potentials. 6 The effects of clonidine were antagonized by piperoxan in a competitive reversible manner. 7 It is argued that these results confirm the presence of alpha-adrenoreceptors prejunctionally upon the sympathetic excitatory innervation of the vas deferens but that although an endogenous alpha-adrenoreceptor agonist is released by nerve stimulation either the transmitter that is responsible for the e.j.p. is not noradrenaline or that the postjunctional receptors responsible for the generation of the e.j.p. are not adrenoreceptors.
Positive_regulation (released) of endogenous alpha-adrenoreceptor in nerve associated with antagonist, noradrenaline, agonist and clonidine
16) Confidence 0.08 Published 1981 Journal J Auton Pharmacol Section Abstract Doc Link 6123511 Disease Relevance 0 Pain Relevance 0.42
Sodium pump stimulation by activation of two alpha adrenergic receptor subtypes in canine blood vessels.
Positive_regulation (activation) of alpha adrenergic receptor in blood vessels
17) Confidence 0.08 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 2835477 Disease Relevance 0 Pain Relevance 0.46
Stimulation of beta-adrenergic receptors activates adenylate cyclase, increasing cyclic AMP levels, whereas alpha-adrenergic receptor stimulation activates phospholipase C, increasing inositol trisphosphate.
Positive_regulation (stimulation) of alpha-adrenergic receptor
18) Confidence 0.08 Published 1990 Journal FASEB J. Section Abstract Doc Link 2185973 Disease Relevance 0.29 Pain Relevance 0.47
Stimulation of alpha-adrenergic receptor augments the production of macrophage-derived tumor necrosis factor.
Positive_regulation (Stimulation) of alpha-adrenergic receptor in macrophage associated with necrosis and cancer
19) Confidence 0.05 Published 1990 Journal J. Immunol. Section Title Doc Link 2166759 Disease Relevance 0.20 Pain Relevance 0.08
These data, combined with hemodynamic correlates, suggest that clonidine inhibits renin release by activation of an intrarenal alpha-adrenergic receptor.
Positive_regulation (activation) of alpha-adrenergic receptor associated with clonidine
20) Confidence 0.04 Published 1976 Journal Circ. Res. Section Abstract Doc Link 5201 Disease Relevance 0.14 Pain Relevance 0.63

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