INT440

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Context Info
Confidence 0.62
First Reported 1979
Last Reported 2010
Negated 10
Speculated 9
Reported most in Abstract
Documents 44
Total Number 53
Disease Relevance 17.71
Pain Relevance 20.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
PVN 14
hypothalamus 10
amygdala 8
visceral 6
hippocampus 5
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 173 100.00 Very High Very High Very High
depression 50 100.00 Very High Very High Very High
Pain 49 100.00 Very High Very High Very High
Morphine 40 100.00 Very High Very High Very High
Visceral pain 40 100.00 Very High Very High Very High
cocaine 37 100.00 Very High Very High Very High
withdrawal 25 100.00 Very High Very High Very High
narcan 19 100.00 Very High Very High Very High
Opioid 15 100.00 Very High Very High Very High
opiate 10 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 111 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

111 100.00 Very High Very High Very High
Depression 56 100.00 Very High Very High Very High
Pain 52 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

40 100.00 Very High Very High Very High
Neuroleptic Malignant Syndrome 3 100.00 Very High Very High Very High
INFLAMMATION 31 99.98 Very High Very High Very High
Urological Neuroanatomy 81 99.84 Very High Very High Very High
Opiate Addiction 2 99.04 Very High Very High Very High
Shock 12 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To assess whether glucocorticoids exert their inhibitory effect on CRH expression directly on parvocellular neurones or indirectly through a complex neuronal circuit, we examined the effect of corticosterone (CORT) and dexamethasone (DEX) on CRH mRNA levels in slice explant cultures of the rat hypothalamus.
Spec (whether) Regulation (effect) of Gene_expression (expression) of CRH in hypothalamus associated with dexamethasone
1) Confidence 0.62 Published 2008 Journal J. Neuroendocrinol. Section Abstract Doc Link 18624927 Disease Relevance 0.09 Pain Relevance 0.22
Effect of fluoxetine on depression-induced changes in the expression of vasoactive intestinal polypeptide and corticotrophin releasing factor in rat duodenum.
Regulation (Effect) of Gene_expression (expression) of corticotrophin releasing factor in duodenum associated with depression and fluoxetine
2) Confidence 0.61 Published 2007 Journal World J. Gastroenterol. Section Title Doc Link 18023100 Disease Relevance 0.10 Pain Relevance 0.38
Prenatal morphine reduced both CRF content in the newborn hypothalamus and CRF immunofluorescence in the median eminence without a significant effect on CRF mRNA expression in the PVN.
Neg (without) Regulation (effect) of Gene_expression (expression) of CRF mRNA in PVN associated with morphine
3) Confidence 0.61 Published 1998 Journal J. Neuroendocrinol. Section Abstract Doc Link 9663647 Disease Relevance 0.16 Pain Relevance 0.92
These effects appeared specific, because the lesion did not alter CRH mRNA expression in the ventral BST, paraventricular nucleus of the hypothalamus or cortex or neurotensin mRNA expression in the CA1 region of the hippocampus.
Neg (not) Regulation (alter) of Gene_expression (expression) of CRH mRNA in hippocampus associated with hippocampus
4) Confidence 0.61 Published 2002 Journal Brain Res. Section Abstract Doc Link 12126877 Disease Relevance 0 Pain Relevance 0.74
In summary, this study has demonstrated that c-Fos-ir in the PVN with an anatomical resolution can be semiquantitatively measured after immunohistochemistry using an image analysis system, and that increased c-fos mRNA in the PVN 1 hr after the AA treatment is associated with no changes of the CRF mRNA expression.
Neg (no) Regulation (changes) of Gene_expression (expression) of CRF mRNA in PVN
5) Confidence 0.59 Published 2007 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 17514764 Disease Relevance 0 Pain Relevance 0.12
The results suggest that the cocaine-induced modulation of hypothalamic CRH mRNA expression is secondary to changes in the activity of specific components of dopaminergic systems.
Regulation (modulation) of Gene_expression (expression) of CRH mRNA associated with cocaine
6) Confidence 0.59 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11597771 Disease Relevance 0.22 Pain Relevance 0.57
Therefore, NPY seems to play a physiological role in the regulation of the release and synthesis of CRF in the hypothalamus.
Regulation (regulation) of Gene_expression (synthesis) of CRF in hypothalamus
7) Confidence 0.57 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8392133 Disease Relevance 0 Pain Relevance 0.13
For assessment of inflammatory regulation of CRF-R expression, rats underwent pulp exposure of left, first mandibular molars and recovered for 6 days.
Regulation (regulation) of Gene_expression (expression) of CRF in molars associated with inflammation
8) Confidence 0.56 Published 2007 Journal J Endod Section Abstract Doc Link 17963955 Disease Relevance 0.30 Pain Relevance 0.15
Effect of naloxone-precipitated morphine withdrawal on c-fos expression in rat corticotropin-releasing hormone neurons in the paraventricular hypothalamus and extended amygdala.
Regulation (Effect) of Gene_expression (expression) of corticotropin-releasing hormone in neurons associated with narcan, amygdala, withdrawal and morphine
9) Confidence 0.54 Published 2004 Journal Neurosci. Lett. Section Title Doc Link 15147776 Disease Relevance 0.09 Pain Relevance 1.12
Consistent with these observations in humans, hypothalamic CRH protein expression was not affected in rats with DHT-induced PCOS.
Neg (not) Regulation (affected) of Gene_expression (expression) of CRH protein associated with polycystic ovary syndrome
10) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722078 Disease Relevance 0.39 Pain Relevance 0.07
In awake rats, corticotropin-releasing factor levels in the mediobasal hypothalamus were 0.98 +/- 0.03 fmol/50 microliters.
Regulation (microliters.) of Gene_expression (levels) of corticotropin-releasing factor in hypothalamus
11) Confidence 0.45 Published 1993 Journal Neuroscience Section Abstract Doc Link 8413932 Disease Relevance 0.14 Pain Relevance 0.04
In late pregnancy, inhibition of 5alpha-reductase (an allopregnanolone-synthesizing enzyme) with finasteride restored HPA axis responses (rapidly increased pPVN CRH mRNA expression, ACTH, and corticosterone secretion) to IL-1beta.
Regulation (responses) of Gene_expression (expression) of pPVN CRH mRNA
12) Confidence 0.45 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19458216 Disease Relevance 0.22 Pain Relevance 0.50
The purpose of this study was to investigate the glucocorticoid (GC) mediated regulation of corticotropin-releasing hormone (CRH) and proenkephalin (PE) gene expressions in the paraventricular nucleus (PVN) of the hypothalamus during physical stress induced by a single intraperitoneal (i.p.) injection of hypertonic saline (9% NaCl).
Regulation (regulation) of Gene_expression (expressions) of corticotropin-releasing hormone in hypothalamus associated with stress
13) Confidence 0.45 Published 1998 Journal Brain Res. Section Abstract Doc Link 9555022 Disease Relevance 0.30 Pain Relevance 0.08
The purpose of this study was to investigate the glucocorticoid (GC) mediated regulation of corticotropin-releasing hormone (CRH) and proenkephalin (PE) gene expressions in the paraventricular nucleus (PVN) of the hypothalamus during physical stress induced by a single intraperitoneal (i.p.) injection of hypertonic saline (9% NaCl).
Regulation (regulation) of Gene_expression (expressions) of CRH in hypothalamus associated with stress
14) Confidence 0.45 Published 1998 Journal Brain Res. Section Abstract Doc Link 9555022 Disease Relevance 0.30 Pain Relevance 0.08
Effects of corticotrophin on pain behavior and BDNF, CRF levels in frontal cortex of rats suffering from chronic pain.
Regulation (Effects) of Gene_expression (levels) of CRF in frontal cortex associated with pain, lasting pain and urological neuroanatomy
15) Confidence 0.45 Published 2000 Journal Acta Pharmacol. Sin. Section Title Doc Link 11360665 Disease Relevance 0.30 Pain Relevance 0.40
Corticotropin-releasing hormone (CRH) has a critical role in most cases, but the changes in c-fos and CRH gene expression in the PVN also reveal differences among drugs.
Regulation (changes) of Gene_expression (expression) of Corticotropin-releasing hormone in PVN
16) Confidence 0.44 Published 2010 Journal Trends Pharmacol. Sci. Section Abstract Doc Link 20537734 Disease Relevance 0 Pain Relevance 0.36
Corticotropin-releasing hormone (CRH) has a critical role in most cases, but the changes in c-fos and CRH gene expression in the PVN also reveal differences among drugs.
Regulation (changes) of Gene_expression (expression) of CRH in PVN
17) Confidence 0.44 Published 2010 Journal Trends Pharmacol. Sci. Section Abstract Doc Link 20537734 Disease Relevance 0 Pain Relevance 0.35
Corticotropin-releasing hormone (CRH) has a critical role in most cases, but the changes in c-fos and CRH gene expression in the PVN also reveal differences among drugs.
Regulation (changes) of Gene_expression (expression) of CRH gene in PVN
18) Confidence 0.44 Published 2010 Journal Trends Pharmacol. Sci. Section Abstract Doc Link 20537734 Disease Relevance 0 Pain Relevance 0.34
Interleukin-1beta (IL-1beta) is involved in hypothalamic regulation of the neuroimmune response by influencing the synthesis and secretion of corticotropin releasing hormone (CRH), vasopressin (VP) and other stress-related mediators.
Regulation (influencing) of Gene_expression (synthesis) of CRH associated with stress
19) Confidence 0.44 Published 2005 Journal Regul. Pept. Section Abstract Doc Link 15927699 Disease Relevance 0.17 Pain Relevance 0
Interleukin-1beta (IL-1beta) is involved in hypothalamic regulation of the neuroimmune response by influencing the synthesis and secretion of corticotropin releasing hormone (CRH), vasopressin (VP) and other stress-related mediators.
Regulation (influencing) of Gene_expression (synthesis) of corticotropin releasing hormone associated with stress
20) Confidence 0.44 Published 2005 Journal Regul. Pept. Section Abstract Doc Link 15927699 Disease Relevance 0.17 Pain Relevance 0

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