INT44001

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Context Info
Confidence 0.59
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.53
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (F12) extracellular space (F12) extracellular region (F12)
Anatomy Link Frequency
plasma 2
macrophages 2
F12 (Mus musculus)
Pain Link Frequency Relevance Heat
cva 2 93.84 High High
cINOD 3 93.68 High High
Pain 2 89.72 High High
Inflammation 6 89.36 High High
Serotonin 1 81.68 Quite High
Angina 1 71.12 Quite High
algogenic 1 68.80 Quite High
aspirin 4 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thrombosis 67 97.76 Very High Very High Very High
Coronary Artery Disease 9 96.92 Very High Very High Very High
Cv General 3 Under Development 2 93.84 High High
Stroke 1 91.96 High High
Pain 3 89.72 High High
INFLAMMATION 5 89.36 High High
Brain Hemorrhage 2 84.00 Quite High
Targeted Disruption 2 79.64 Quite High
Disseminated Intravascular Coagulation 3 75.00 Quite High
Angina 1 71.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, a complete evaluation of all these properties of FXII and FXIIa has to be considered when formulating a strategy for blocking FXII activation.
Negative_regulation (blocking) of Positive_regulation (activation) of FXII
1) Confidence 0.59 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 17996217 Disease Relevance 0.55 Pain Relevance 0.17
The target mentioned above may either be an inhibition of FXII activation or an inhibition of its proteolytic activity.
Negative_regulation (inhibition) of Positive_regulation (activation) of FXII
2) Confidence 0.59 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 17996217 Disease Relevance 0.67 Pain Relevance 0.15
Increased FXII zymogen levels have primarily been associated with a decrease in risk for MI and outcome [29,31].
Negative_regulation (decrease) of Positive_regulation (Increased) of FXII
3) Confidence 0.35 Published 2010 Journal Thromb J Section Body Doc Link PMC2871266 Disease Relevance 1.01 Pain Relevance 0.07
Glucocorticoids prevent activation of factor XII by endotoxin in vivo and decrease production of tissue factor by macrophages.
Negative_regulation (prevent) of Positive_regulation (activation) of factor XII in macrophages
4) Confidence 0.32 Published 1983 Journal Agents Actions Section Abstract Doc Link 6356816 Disease Relevance 0.23 Pain Relevance 0.23
The D7 protein named hamadarin from Anopheles stephensi acts as an anticoagulant affecting the plasma contact system by inhibiting the activation of Factor XII and kallikrein [23].
Negative_regulation (inhibiting) of Positive_regulation (activation) of Factor XII in plasma
5) Confidence 0.01 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1434747 Disease Relevance 0.07 Pain Relevance 0.11

General Comments

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