INT44002

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Context Info
Confidence 0.20
First Reported 1983
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.64
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (F3) aging (F3) cytoplasm (F3)
Anatomy Link Frequency
monocytes 5
macrophages 4
platelets 3
F3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 16 99.66 Very High Very High Very High
cINOD 58 98.64 Very High Very High Very High
Inflammation 20 84.84 Quite High
Osteoarthritis 10 79.60 Quite High
Angina 5 78.04 Quite High
Pain 4 77.36 Quite High
diclofenac 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Lasting pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Coronary Syndrome 6 97.00 Very High Very High Very High
Atherosclerotic Plaque 1 91.00 High High
Rupture 1 88.24 High High
INFLAMMATION 25 84.84 Quite High
Thrombosis 6 84.08 Quite High
Cardiovascular Disease 15 82.88 Quite High
Osteoarthritis 10 79.60 Quite High
Cv General 3 Under Development 5 78.04 Quite High
Pain 5 77.36 Quite High
Myocardial Infarction 5 77.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased expression of tissue factor is not limited to the plaque but is also found in circulating monocytes in patients with acute coronary syndromes.
Neg (not) Negative_regulation (limited) of Gene_expression (expression) of tissue factor in monocytes associated with acute coronary syndrome
1) Confidence 0.20 Published 2002 Journal Cardiovasc. Res. Section Abstract Doc Link 11827681 Disease Relevance 0.75 Pain Relevance 0.08
Glucocorticoids prevent activation of factor XII by endotoxin in vivo and decrease production of tissue factor by macrophages.
Negative_regulation (prevent) of Gene_expression (production) of tissue factor in macrophages
2) Confidence 0.03 Published 1983 Journal Agents Actions Section Abstract Doc Link 6356816 Disease Relevance 0.23 Pain Relevance 0.24
Glucocorticoids prevent activation of factor XII by endotoxin in vivo and decrease production of tissue factor by macrophages.
Negative_regulation (decrease) of Gene_expression (production) of tissue factor in macrophages
3) Confidence 0.03 Published 1983 Journal Agents Actions Section Abstract Doc Link 6356816 Disease Relevance 0.23 Pain Relevance 0.24
In addition, unlike aspirin alone, NCX 4016 inhibited tissue factor expression on lipopolysaccharide-stimulated monocytes, suggesting that NCX 4016 has NO mediated activity in addition to COX inhibiting activity [51].
Negative_regulation (inhibited) of Gene_expression (expression) of tissue factor in monocytes associated with aspirin
4) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582807 Disease Relevance 0.45 Pain Relevance 0.42
Tissue factor, a measure of endothelial perturbation, was measured as expression on monocytes and platelets, as numbers of tissue factor expressing MP, and as plasma protein [see Supplemental Material, Table 4 (doi:10.1289/ehp.1002237)].
Negative_regulation (numbers) of Gene_expression (expressing) of tissue factor in platelets
5) Confidence 0.00 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC3002188 Disease Relevance 0 Pain Relevance 0
Tissue factor, a measure of endothelial perturbation, was measured as expression on monocytes and platelets, as numbers of tissue factor expressing MP, and as plasma protein [see Supplemental Material, Table 4 (doi:10.1289/ehp.1002237)].
Negative_regulation (numbers) of in monocytes Gene_expression (expressing) of tissue factor in platelets
6) Confidence 0.00 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC3002188 Disease Relevance 0 Pain Relevance 0

General Comments

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