INT44003

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Context Info
Confidence 0.75
First Reported 1983
Last Reported 2011
Negated 3
Speculated 0
Reported most in Abstract
Documents 40
Total Number 41
Disease Relevance 27.92
Pain Relevance 8.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (F3) aging (F3) cytoplasm (F3)
Anatomy Link Frequency
monocytes 12
platelets 7
macrophages 3
leukocytes 3
endothelial cells 3
F3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 45 99.76 Very High Very High Very High
aspirin 28 99.46 Very High Very High Very High
Angina 105 99.28 Very High Very High Very High
cINOD 57 98.64 Very High Very High Very High
Opioid 10 97.42 Very High Very High Very High
cva 4 96.72 Very High Very High Very High
Hippocampus 4 93.28 High High
cerebral cortex 4 92.64 High High
Inflammatory marker 6 92.48 High High
Inflammation 83 88.28 High High
Disease Link Frequency Relevance Heat
Acute Coronary Syndrome 62 100.00 Very High Very High Very High
Pressure And Volume Under Development 43 100.00 Very High Very High Very High
Thrombosis 50 99.92 Very High Very High Very High
Apoptosis 12 99.84 Very High Very High Very High
Thrombophilia 4 99.76 Very High Very High Very High
Atherosclerotic Plaque 10 99.30 Very High Very High Very High
Cv General 3 Under Development 105 99.28 Very High Very High Very High
Obesity 90 99.00 Very High Very High Very High
Myocardial Infarction 37 98.34 Very High Very High Very High
Coronary Artery Disease 66 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Monocytes play an important role in the induction of tissue-factor expression 2, which is seen as a key event in the development of DIC in septic patients.
Gene_expression (expression) of tissue-factor in Monocytes associated with disseminated intravascular coagulation
1) Confidence 0.75 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1925152 Disease Relevance 1.22 Pain Relevance 0.05
Only trace levels of Kilon and opioid-binding cell adhesion molecule were detected in the soluble fraction of a cortical homogenate, although a substantial amount of F3 was present in the soluble fraction.
Gene_expression (present) of F3 associated with opioid and adhesions
2) Confidence 0.42 Published 2003 Journal Neuroscience Section Abstract Doc Link 12617969 Disease Relevance 0.68 Pain Relevance 0.77
Several mediators involved in the process of atherosclerotic plaque formation are capable of inducing tissue factor expression in cells such as monocytes, macrophages and endothelial cells, which under normal conditions do not express tissue factor or to a limited extent only.
Neg (not) Gene_expression (express) of tissue factor in macrophages associated with atherosclerotic plaque
3) Confidence 0.35 Published 2002 Journal Cardiovasc. Res. Section Abstract Doc Link 11827681 Disease Relevance 0.74 Pain Relevance 0.08
Several mediators involved in the process of atherosclerotic plaque formation are capable of inducing tissue factor expression in cells such as monocytes, macrophages and endothelial cells, which under normal conditions do not express tissue factor or to a limited extent only.
Gene_expression (expression) of tissue factor in macrophages associated with atherosclerotic plaque
4) Confidence 0.35 Published 2002 Journal Cardiovasc. Res. Section Abstract Doc Link 11827681 Disease Relevance 0.73 Pain Relevance 0.09
BACKGROUND: Macrophage expression of tissue factor may be responsible for coronary thrombogenicity in patients with plaque rupture.
Gene_expression (expression) of tissue factor in plaque associated with rupture
5) Confidence 0.28 Published 1996 Journal Circulation Section Abstract Doc Link 8989114 Disease Relevance 0.34 Pain Relevance 0.15
The increased expression of tissue factor is not limited to the plaque but is also found in circulating monocytes in patients with acute coronary syndromes.
Gene_expression (expression) of tissue factor in monocytes associated with acute coronary syndrome
6) Confidence 0.27 Published 2002 Journal Cardiovasc. Res. Section Abstract Doc Link 11827681 Disease Relevance 0.74 Pain Relevance 0.08
Cumulative percent drug release for F1, F2 after 16 h was 97.22%, 94.88% and for F-3, F-4 after 24 h was 81.39% and 78.43%, respectively, and was 93.93 % in 3 h for pure drug cisplatin (fig. 2).
Gene_expression (for) of F-3
7) Confidence 0.16 Published 2008 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2792476 Disease Relevance 0 Pain Relevance 0
The hypercoagulability is associated with expression of tissue factor in patients with angina.
Gene_expression (expression) of tissue factor associated with angina and thrombophilia
8) Confidence 0.15 Published 1999 Journal Thromb. Res. Section Abstract Doc Link 10065895 Disease Relevance 0.62 Pain Relevance 0.52
In addition to these effects, Vitamin D may also inhibit the cytokines effect on target cells. vitamin D has an antagonistic effect on TNF-alpha stimulation of monocytes in cultures by down-regulating the surface protein tissue factor (TF) and up-regulating trombomodulin (TM) expression in monocytic cells 18.
Gene_expression (expression) of tissue factor in monocytes associated with cytokine
9) Confidence 0.13 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1925152 Disease Relevance 0.54 Pain Relevance 0.22
Several mediators involved in the process of atherosclerotic plaque formation are capable of inducing tissue factor expression in cells such as monocytes, macrophages and endothelial cells, which under normal conditions do not express tissue factor or to a limited extent only.
Neg (not) Gene_expression (express) of tissue factor in monocytes associated with atherosclerotic plaque
10) Confidence 0.12 Published 2002 Journal Cardiovasc. Res. Section Abstract Doc Link 11827681 Disease Relevance 0.74 Pain Relevance 0.08
Several mediators involved in the process of atherosclerotic plaque formation are capable of inducing tissue factor expression in cells such as monocytes, macrophages and endothelial cells, which under normal conditions do not express tissue factor or to a limited extent only.
Neg (not) Gene_expression (express) of tissue factor in endothelial cells associated with atherosclerotic plaque
11) Confidence 0.12 Published 2002 Journal Cardiovasc. Res. Section Abstract Doc Link 11827681 Disease Relevance 0.74 Pain Relevance 0.08
Several mediators involved in the process of atherosclerotic plaque formation are capable of inducing tissue factor expression in cells such as monocytes, macrophages and endothelial cells, which under normal conditions do not express tissue factor or to a limited extent only.
Gene_expression (expression) of tissue factor in monocytes associated with atherosclerotic plaque
12) Confidence 0.12 Published 2002 Journal Cardiovasc. Res. Section Abstract Doc Link 11827681 Disease Relevance 0.73 Pain Relevance 0.09
Several mediators involved in the process of atherosclerotic plaque formation are capable of inducing tissue factor expression in cells such as monocytes, macrophages and endothelial cells, which under normal conditions do not express tissue factor or to a limited extent only.
Gene_expression (expression) of tissue factor in endothelial cells associated with atherosclerotic plaque
13) Confidence 0.12 Published 2002 Journal Cardiovasc. Res. Section Abstract Doc Link 11827681 Disease Relevance 0.73 Pain Relevance 0.09
Leukocyte infiltration in the vascular wall accompanies PAI-1, MCP-1, iNOS and Tissue Factor expression.
Gene_expression (expression) of Tissue Factor in Leukocyte
14) Confidence 0.10 Published 2002 Journal BMC Cardiovasc Disord Section Abstract Doc Link PMC65512 Disease Relevance 1.04 Pain Relevance 0.08
In case of formulations F2, F3 and F6, the swelling was higher in F2 than F3 and F6, while amongst F3 and F6, swelling was more in F3.
Gene_expression (more) of F3 associated with pressure and volume under development
15) Confidence 0.07 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007615 Disease Relevance 0.91 Pain Relevance 0
In case of formulations F2, F3 and F6, the swelling was higher in F2 than F3 and F6, while amongst F3 and F6, swelling was more in F3.
Gene_expression (more) of F3 associated with pressure and volume under development
16) Confidence 0.07 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007615 Disease Relevance 0.90 Pain Relevance 0
Glucocorticoids prevent activation of factor XII by endotoxin in vivo and decrease production of tissue factor by macrophages.
Gene_expression (production) of tissue factor in macrophages
17) Confidence 0.05 Published 1983 Journal Agents Actions Section Abstract Doc Link 6356816 Disease Relevance 0.23 Pain Relevance 0.24
Tissue factor is expressed in apoptotic macrophages, suggesting that macrophages are not only responsible for plaque disruption but also pivotal in thrombus generation, the most important mechanism of acute coronary syndromes.
Gene_expression (expressed) of Tissue factor in plaque associated with acute coronary syndrome, apoptosis and thrombosis
18) Confidence 0.04 Published 2001 Journal J Stroke Cerebrovasc Dis Section Abstract Doc Link 17903843 Disease Relevance 1.49 Pain Relevance 0.08
In addition, unlike aspirin alone, NCX 4016 inhibited tissue factor expression on lipopolysaccharide-stimulated monocytes, suggesting that NCX 4016 has NO mediated activity in addition to COX inhibiting activity [51].
Gene_expression (expression) of tissue factor in monocytes associated with aspirin
19) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582807 Disease Relevance 0.44 Pain Relevance 0.42
We determined the ability of plasma obtained from patients with either unstable angina or non-ST segment elevation myocardial infarction (MI) receiving the LMWH enoxaparin (anti Xa:IIa ratio 3:1) to inhibit tissue factor-mediated thrombin generation and to inactivate platelet prothrombinase.
Gene_expression (generation) of tissue factor in platelet associated with angina and myocardial infarction
20) Confidence 0.02 Published 2000 Journal J. Thromb. Thrombolysis Section Abstract Doc Link 10728020 Disease Relevance 0.27 Pain Relevance 0.10

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