INT44016

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Context Info
Confidence 0.10
First Reported 1983
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.53
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp27b1) oxidoreductase activity (Cyp27b1) aging (Cyp27b1)
cytoplasm (Cyp27b1)
Anatomy Link Frequency
B27M2 1
Cyp27b1 (Mus musculus)
Pain Link Frequency Relevance Heat
spinal inflammation 1 94.84 High High
Paracetamol 7 88.44 High High
Potency 1 72.96 Quite High
Bile 11 5.00 Very Low Very Low Very Low
diclofenac 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Morphine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease Susceptibility 1 99.44 Very High Very High Very High
Low Back Pain 1 94.84 High High
Targeted Disruption 15 77.44 Quite High
Hepatotoxicity 3 75.00 Quite High
Severe Combined Immunodeficiency 6 57.40 Quite High
Disease 2 55.20 Quite High
Hepatitis C Virus Infection 9 5.00 Very Low Very Low Very Low
Hepatitis B Virus Infection 8 5.00 Very Low Very Low Very Low
Infection 6 5.00 Very Low Very Low Very Low
Hepatitis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ethoxyresorufin O-deethylase activity, associated with both CYP1A1 and CYP1A2, was also significantly elevated in this group.
CYP1A1 Binding (associated) of
1) Confidence 0.10 Published 1997 Journal Pharmacogenetics Section Abstract Doc Link 9295056 Disease Relevance 0.14 Pain Relevance 0.46
B27M1 antibody reactivity does not appear to be associated with unusual disease susceptibility but preliminary data suggest the B27M2- variant of B27 may be more strongly associated with ankylosing spondylitis.
B27M1 Binding (associated) of in B27M2 associated with disease susceptibility and spinal inflammation
2) Confidence 0.02 Published 1983 Journal Br. J. Rheumatol. Section Abstract Doc Link 6360285 Disease Relevance 0.25 Pain Relevance 0.09
The binding of 3-MC to the aryl hydrocarbon receptor (AHR) forms a AHR/3-MC complex, which upregulates CYP1A1, CYP1A2, and CYP1B1 expression by binding, together with the AHR nuclear translocator (ARNT), to the XREs of these genes [30].
CYP1A1 Binding (binding) of
3) Confidence 0.01 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0.13 Pain Relevance 0.04

General Comments

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