INT4402

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Context Info
Confidence 0.49
First Reported 1975
Last Reported 2006
Negated 0
Speculated 2
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.33
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2B6) endoplasmic reticulum (CYP2B6)
CYP2B6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Buprenorphine 14 98.38 Very High Very High Very High
withdrawal 1 98.16 Very High Very High Very High
fluoxetine 4 95.76 Very High Very High Very High
anesthesia 3 88.64 High High
depression 1 75.40 Quite High
Serotonin 1 72.56 Quite High
fortral 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Porphyria 3 97.88 Very High Very High Very High
Depression 1 75.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased formation of cytochrome P-450 with barbiturates also produces increased levels of delta aminolevulinic acid, which may be a cause of the acute attack.
Positive_regulation (Increased) of P-450 Binding (formation) of associated with porphyria
1) Confidence 0.49 Published 1975 Journal South. Med. J. Section Abstract Doc Link 1154054 Disease Relevance 0.25 Pain Relevance 0.16
It is an inhibitor of cytochrome P450 (CYP) 2D6 and other CYP enzymes, which increases the potential for drug interactions.
Positive_regulation (increases) of P450 Binding (interactions) of
2) Confidence 0.49 Published 2004 Journal Expert Opin Drug Saf Section Abstract Doc Link 15335304 Disease Relevance 0.08 Pain Relevance 0.45
The in vitro metabolism of buprenorphine was investigated to explore new metabolic pathways and identify the cytochromes P450 (P450s) responsible for the formation of these metabolites.
Spec (investigated) Positive_regulation (responsible) of P450 Binding (formation) of associated with buprenorphine
3) Confidence 0.49 Published 2006 Journal Drug Metab. Dispos. Section Abstract Doc Link 16381669 Disease Relevance 0 Pain Relevance 0.37
The in vitro metabolism of buprenorphine was investigated to explore new metabolic pathways and identify the cytochromes P450 (P450s) responsible for the formation of these metabolites.
Spec (investigated) Positive_regulation (responsible) of P450s Binding (formation) of associated with buprenorphine
4) Confidence 0.10 Published 2006 Journal Drug Metab. Dispos. Section Abstract Doc Link 16381669 Disease Relevance 0 Pain Relevance 0.37

General Comments

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