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Context Info
Confidence 0.40
First Reported 1983
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.76
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lif) extracellular region (Lif)
Anatomy Link Frequency
Notch 1
spinal cord 1
nerve 1
lateral 1
lens 1
Lif (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 108 99.48 Very High Very High Very High
spinal inflammation 3 98.48 Very High Very High Very High
Pain 14 97.92 Very High Very High Very High
qutenza 4 97.72 Very High Very High Very High
unmyelinated 3 96.36 Very High Very High Very High
agonist 29 93.76 High High
chemokine 4 91.32 High High
cytokine 47 90.72 High High
intrathecal 1 89.56 High High
Sciatic nerve 1 81.28 Quite High
Disease Link Frequency Relevance Heat
Leukemia 3 100.00 Very High Very High Very High
Wallerian Degeneration 4 99.84 Very High Very High Very High
Spinal Cord Injury 109 99.68 Very High Very High Very High
Klebsiella Infection 1 99.48 Very High Very High Very High
Low Back Pain 4 98.48 Very High Very High Very High
Pain 12 97.92 Very High Very High Very High
Optic Nerve Injuries 2 97.04 Very High Very High Very High
Cicatrix 12 89.28 High High
Injury 213 85.96 High High
Apoptosis 48 74.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
METHODS: Between 1998 and 2001, 14 patients underwent lateral LIF with anterolateral instrumentation to treat degenerative foraminal stenosis or spondylolisthesis.
Positive_regulation (underwent) of LIF in lateral
1) Confidence 0.40 Published 2006 Journal Surg Neurol Section Body Doc Link 16427396 Disease Relevance 0 Pain Relevance 0
However, consistent with the array results, there was a 2-fold increase in LIF and a 4-fold increase in TGFß1 (Table 1).
Positive_regulation (increase) of LIF
2) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832687 Disease Relevance 0.15 Pain Relevance 0
Klebsiella-induced LIF response in Klebsiella infection and ankylosing spondylitis.
Positive_regulation (induced) of LIF associated with spinal inflammation and klebsiella infection
3) Confidence 0.24 Published 1983 Journal Br. J. Rheumatol. Section Title Doc Link 6360292 Disease Relevance 0.38 Pain Relevance 0.28
CNTF, LIF and IL-6 are known to be upregulated at sites of spinal cord injury [60-65] and it is possible that some or all of these factors may also drive the differentiation of local endogenous glial precursors to a GDACNTF-like phenotype (Olig2+/GFAP+) that contributes to the formation of axon-growth-inhibitory scar tissue.
Positive_regulation (upregulated) of LIF in spinal cord associated with cicatrix and spinal cord
4) Confidence 0.19 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 1.11 Pain Relevance 0.61
According to this view, SP cells/nestin-positive cells may play a role in local homeostasis and tissue remodelling, particularly because their number increases in response to various growth factors, such as leukaemia-inhibitory factor (LIF), FGF-2 and EGF, and in response to activating the Notch pathway (658), and as in aggregate cell culture nestin-positive cells organise in a network with long cellular extensions (648).
Positive_regulation (increases) of LIF in Notch associated with leukemia
5) Confidence 0.13 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.10 Pain Relevance 0
Recently, it was demonstrated that LIF and CNTF are important growth factors caused by lens damage that protect RGCs and stimulate axonal regeneration after optic nerve injury [71].
Positive_regulation (caused) of LIF in lens associated with optic nerve injuries
6) Confidence 0.11 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2894843 Disease Relevance 0.67 Pain Relevance 0.21
Upregulation of MCP-1, IL-2, IL-6 and IL-10 were seen in both groups but IL-1ss and LIF were primarily upregulated in Wallerian degeneration of the whole nerve and not in capsaicin-induced degeneration of unmyelinated axons.
Neg (not) Positive_regulation (upregulated) of LIF in nerve associated with qutenza, wallerian degeneration and unmyelinated
7) Confidence 0.08 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18068300 Disease Relevance 0.35 Pain Relevance 0.80

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