INT4403

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Context Info
Confidence 0.48
First Reported 1975
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 113
Total Number 114
Disease Relevance 21.17
Pain Relevance 33.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2B6) endoplasmic reticulum (CYP2B6)
Anatomy Link Frequency
liver 11
1A2 6
plasma 4
cortex 4
hepatocytes 1
CYP2B6 (Homo sapiens)
Pain Link Frequency Relevance Heat
methadone 84 100.00 Very High Very High Very High
antagonist 82 100.00 Very High Very High Very High
Paracetamol 65 100.00 Very High Very High Very High
fluoxetine 56 100.00 Very High Very High Very High
Codeine 38 100.00 Very High Very High Very High
Buprenorphine 34 100.00 Very High Very High Very High
cINOD 34 100.00 Very High Very High Very High
monoamine 10 100.00 Very High Very High Very High
adenocard 6 100.00 Very High Very High Very High
Cholecystokinin 2 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 79 99.60 Very High Very High Very High
Cognitive Disorder 35 99.36 Very High Very High Very High
Hepatotoxicity 10 99.16 Very High Very High Very High
Pressure And Volume Under Development 9 99.06 Very High Very High Very High
Schizophrenia 69 99.04 Very High Very High Very High
Injury 29 98.68 Very High Very High Very High
Arthralgia 4 98.52 Very High Very High Very High
Sleep Disorders 32 98.40 Very High Very High Very High
Porphyria 3 97.88 Very High Very High Very High
Necrosis 2 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For CYP2B6, the interaction between enantiomers was stereoselective, with S-methadone as a more potent inhibitor of R-methadone N-demethylation than R-of S-methadone.
CYP2B6 Binding (interaction) of associated with methadone
1) Confidence 0.48 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17259447 Disease Relevance 0 Pain Relevance 1.01
Codeine binds to P450 2D6 so that the methoxy group is directly above the A ring of the heme, while the basic nitrogen interacts with the carboxylate of aspartate 301.
P450 Binding (binds) of associated with codeine
2) Confidence 0.47 Published 1996 Journal Biochemistry Section Abstract Doc Link 8605204 Disease Relevance 0 Pain Relevance 0.42
These advantages include its potency, relatively longer elimination half-life, and lack of interaction with the cytochrome P450 isoforms.
P450 Binding (interaction) of associated with potency
3) Confidence 0.47 Published 1996 Journal Clin Pharmacokinet Section Abstract Doc Link 8853932 Disease Relevance 0.19 Pain Relevance 0.16
Neither compound interacts with cytochrome P450 mixed-function oxidases or glucuronosyltransferases.
P450 Neg (Neither) Binding (interacts) of
4) Confidence 0.47 Published 1999 Journal Clin Pharmacokinet Section Abstract Doc Link 10628898 Disease Relevance 0.23 Pain Relevance 0.04
[Analysis on associations of cytochrome P450 1A1-Hinc II and glutathion S-transferase-theta with primary dysmenorrhea].
P450 Binding (associations) of associated with dismenorea
5) Confidence 0.47 Published 2001 Journal Zhonghua Yi Xue Yi Chuan Xue Za Zhi Section Title Doc Link 11172643 Disease Relevance 0.10 Pain Relevance 0.29
Mibefradil has been withdrawn by the manufacturer because of drug interaction at the cytochrome P-450 3A4 enzyme.
P-450 Binding (interaction) of
6) Confidence 0.47 Published 1999 Journal Am J Ther Section Abstract Doc Link 11329102 Disease Relevance 0.19 Pain Relevance 0.22
Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450.
P450 Binding (interacting) of
7) Confidence 0.47 Published 2002 Journal Chem. Biol. Interact. Section Title Doc Link 11803026 Disease Relevance 0.26 Pain Relevance 0.13
Tienilic acid-reactive metabolite(s) specifically bound to P450 2C9, and experiments with yeast expressing active isolated P450s showed that P450 2C9 was responsible for tienilic acid-reactive metabolite(s) production.
P450 Binding (bound) of
8) Confidence 0.47 Published 1994 Journal Chem. Res. Toxicol. Section Abstract Doc Link 8075377 Disease Relevance 0.32 Pain Relevance 0.07
Among the proteins that interact with flavonoids, cytochromes P450 (CYPs), monooxygenases metabolizing xenobiotics (e.g. drugs, carcinogens) and endogenous substrates (e.g. steroids), play a prominent role.
P450 Binding (interact) of
9) Confidence 0.47 Published 2002 Journal Chem. Biol. Interact. Section Abstract Doc Link 11803026 Disease Relevance 0.26 Pain Relevance 0.13
Increased formation of cytochrome P-450 with barbiturates also produces increased levels of delta aminolevulinic acid, which may be a cause of the acute attack.
P-450 Binding (formation) of associated with porphyria
10) Confidence 0.47 Published 1975 Journal South. Med. J. Section Abstract Doc Link 1154054 Disease Relevance 0.25 Pain Relevance 0.16
The pharmacokinetic properties of lacosamide include a fast rate of absorption, little or no interaction with cytochrome P450 isoenzymes, limited effect of age and gender on plasma levels and low potential for drug-drug interactions.
P450 Neg (no) Binding (interaction) of in plasma associated with lacosamide
11) Confidence 0.47 Published 2008 Journal Expert Rev Neurother Section Abstract Doc Link 18986235 Disease Relevance 0.65 Pain Relevance 0.78
Multivariate regression analysis allowed attribution of 31.8% of QTc variability to methadone dose, cytochrome P-450 3A4 drug-drug interactions, hypokalemia, and altered liver function.
P-450 Binding (interactions) of in liver
12) Confidence 0.47 Published 2006 Journal Arch. Intern. Med. Section Body Doc Link 16801510 Disease Relevance 0 Pain Relevance 0
The lack of hepatic metabolism and lack of interaction with cytochrome P-450 isoenzymes explain the absence of drug interactions with pregabalin.
P-450 Binding (interaction) of
13) Confidence 0.47 Published 2007 Journal Am J Health Syst Pharm Section Body Doc Link 17617497 Disease Relevance 0 Pain Relevance 0
A list of the cytochrome P450 2D6 pharmacotherapies that will interact with propoxyphene is provided in the article.
P450 Binding (interact) of
14) Confidence 0.47 Published 2006 Journal Am J Ther Section Abstract Doc Link 17122535 Disease Relevance 0.24 Pain Relevance 0.63
Several narcotics were screened for in vitro interaction with this P-450 isozyme.
P-450 isozyme Binding (interaction) of
15) Confidence 0.43 Published 1989 Journal Anesthesiology Section Abstract Doc Link 2563318 Disease Relevance 0 Pain Relevance 0.43
Interaction of the enantiomers of fluoxetine and norfluoxetine with human liver cytochromes P450.
P450 Binding (Interaction) of in liver associated with fluoxetine
16) Confidence 0.40 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 8355218 Disease Relevance 0 Pain Relevance 0.43
Furthermore, antiserum recognizing P450 2D6 inhibited 82% of microsomal bufuralol 1'-hydroxylase activity but only 27% of the (R)-fluoxetine N-demethylase activity in the same human liver sample.
P450 Binding (recognizing) of in liver associated with fluoxetine
17) Confidence 0.40 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8355218 Disease Relevance 0 Pain Relevance 0.61
Mepyramine bound specifically to P450 2D1, which suggests that it inhibits P450 2D activity.
P450 Binding (bound) of
18) Confidence 0.38 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7853212 Disease Relevance 0 Pain Relevance 0.21
The interaction of antihistaminics, including mepyramine, with rat hepatic cytochrome P450s (P450s) was investigated.
P450s Binding (interaction) of
19) Confidence 0.38 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7853212 Disease Relevance 0 Pain Relevance 0.19
CYP2B6 metabolizes a number of drug substrates, that are usually non-planar, neutral or weakly basic, fairly lipophilic with one or two hydrogen bond acceptors, on which it catalyses various oxidative reactions.
CYP2B6 Binding (metabolizes) of
20) Confidence 0.37 Published 2006 Journal Curr. Drug Metab. Section Abstract Doc Link 17073575 Disease Relevance 0 Pain Relevance 0.12

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