INT44058

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Context Info
Confidence 0.74
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.73
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP21A2) endoplasmic reticulum (CYP21A2)
Anatomy Link Frequency
brain 1
CYP21A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 3 100.00 Very High Very High Very High
Somatostatin 1 100.00 Very High Very High Very High
Enkephalin 1 99.76 Very High Very High Very High
Substantia nigra 1 71.20 Quite High
Spinal cord 1 27.52 Quite Low
Dorsal horn 1 25.00 Low Low
dexamethasone 5 5.00 Very Low Very Low Very Low
iatrogenic 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adrenal Cancer 137 88.24 High High
Reprotox - General 3 5 71.16 Quite High
Reprotox - General 1 8 70.64 Quite High
Amputation 1 25.00 Low Low
Hirsutism 16 5.00 Very Low Very Low Very Low
Polycystic Ovary Syndrome 14 5.00 Very Low Very Low Very Low
Alopecia 10 5.00 Very Low Very Low Very Low
Acne 7 5.00 Very Low Very Low Very Low
Precocious Puberty 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most of the mutations result from recombination between the active gene, CYP21A2, and its highly homologous non-functional pseudogene, CYP21A1P (i.e., gene conversion), which is located in close proximity within the HLA region on chromosome 6p21.3.
Localization (located) of CYP21A2
1) Confidence 0.74 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2910408 Disease Relevance 0.73 Pain Relevance 0
With both approaches it was possible to localize a number of antigens such as somatostatin, substance P, avian pancreatic polypeptide, tyrosine hydroxylase, and enkephalin-like immunoreactivity in various regions of the rat and human brain.
Localization (localize) of hydroxylase in brain associated with somatostatin, enkephalin and substance p
2) Confidence 0.10 Published 1984 Journal Brain Res. Section Abstract Doc Link 6365244 Disease Relevance 0 Pain Relevance 0.27

General Comments

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